Department of Physiology and Pharmacology,
Sackler Faculty of Medicine,
Sagol School of Neuroscience,
Department of Physiology and Pharmacology, Sackler Faculty of Medicine
Eran Perlson completed a B.Sc. in biological studies at Tel-Aviv University and a Ph.D. at the Weizmann Institute of Science in molecular and cellular neurobiology. As a Postdoctoral Research Fellow he focused on understanding the mechanisms underlying neurodegenerative diseases. In October 2010, Eran returned to Tel-Aviv University Medical School as an Assistant Professor to continue his research on axonal transport and neurodegeneration. At 2017 he become Associate Professor. The long-term research goal of his lab is to understand molecular communications mechanisms between the neurons to its environment that plays essential role in neuronal survival and synapse stability. His scientific work has earned him a large number of distinguished grants, awards and honors, including the ERC starter grant (2012), Sieratzki-Korczyn Prize for Advances in Neuroscience (2010); The Muscular Dystrophy Association, development grant, (2008); and The Milton Safenowitz Post Doctoral Fellowship for ALS Research, ALSA, (2005). Eran is the author of numerous publications in high profile journals and invited speaker to leading international meetings.
Dynein tethers and stabilizes dynamic microtubule plus ends.
Current biology : CB Apr, 2012 | Pubmed ID: 22445300
Dynein interacts with the neural cell adhesion molecule (NCAM180) to tether dynamic microtubules and maintain synaptic density in cortical neurons.
The Journal of biological chemistry Sep, 2013 | Pubmed ID: 23960070
Long-distance axonal transport of AAV9 is driven by dynein and kinesin-2 and is trafficked in a highly motile Rab7-positive compartment.
Molecular therapy : the journal of the American Society of Gene Therapy Mar, 2014 | Pubmed ID: 24100640
Real-time sensing of enteropathogenic E. coli-induced effects on epithelial host cell height, cell-substrate interactions, and endocytic processes by infrared surface plasmon spectroscopy.
PloS one , 2013 | Pubmed ID: 24194932
Rabies Virus Hijacks and accelerates the p75NTR retrograde axonal transport machinery.
PLoS pathogens Aug, 2014 | Pubmed ID: 25165859
Anterograde glycoprotein-dependent transport of newly generated rabies virus in dorsal root ganglion neurons.
Journal of virology Dec, 2014 | Pubmed ID: 25275124
A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions.
Journal of cell science Mar, 2015 | Pubmed ID: 25632161
Amyotrophic lateral sclerosis as a spatiotemporal mislocalization disease: location, location, location.
International review of cell and molecular biology , 2015 | Pubmed ID: 25708461
A Dynein Light Chain 1 Binding Motif in Rabies Virus Polymerase L Protein Plays a Role in Microtubule Reorganization and Viral Primary Transcription.
Journal of virology Sep, 2015 | Pubmed ID: 26157129
Receptor-mediated increase in rabies virus axonal transport.
Neural regeneration research Jun, 2015 | Pubmed ID: 26199597
Developmental Axon Pruning Requires Destabilization of Cell Adhesion by JNK Signaling.
Neuron Dec, 2015 | Pubmed ID: 26586184
Proteomic Analysis of Dynein-Interacting Proteins in Amyotrophic Lateral Sclerosis Synaptosomes Reveals Alterations in the RNA-Binding Protein Staufen1.
Molecular & cellular proteomics : MCP Feb, 2016 | Pubmed ID: 26598648
Neurodegeneration and Alzheimer's disease (AD). What Can Proteomics Tell Us About the Alzheimer's Brain?
Molecular & cellular proteomics : MCP Feb, 2016 | Pubmed ID: 26657538
Compartmental microfluidic system for studying muscle-neuron communication and neuromuscular junction maintenance.
European journal of cell biology Feb, 2016 | Pubmed ID: 26689471
Tracking Quantum-Dot labeled neurotropic factors transport along primary neuronal axons in compartmental microfluidic chambers.
Methods in cell biology , 2016 | Pubmed ID: 26794524
Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia.
PLoS genetics Dec, 2016 | Pubmed ID: 27997532
ALS Along the Axons - Expression of Coding and Noncoding RNA Differs in Axons of ALS models.
Scientific reports Mar, 2017 | Pubmed ID: 28300211
Spatial-specific functions in retrograde neuronal signalling.
Traffic (Copenhagen, Denmark) 07, 2017 | Pubmed ID: 28393448
Phosphatidylserine improves axonal transport by inhibition of HDAC and has potential in treatment of neurodegenerative diseases.
Neural regeneration research Apr, 2017 | Pubmed ID: 28553323
High content image analysis reveals function of miR-124 upstream of Vimentin in regulating motor neuron mitochondria.
Scientific reports 01, 2018 | Pubmed ID: 29311649
The receptor tyrosine kinase TrkB signals without dimerization at the plasma membrane.
Science signaling 05, 2018 | Pubmed ID: 29739881
miR126-5p Downregulation Facilitates Axon Degeneration and NMJ Disruption via a Non-Cell-Autonomous Mechanism in ALS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 06, 2018 | Pubmed ID: 29773756
Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150 Deacetylation by Axonal HDAC1.
Developmental cell 08, 2018 | Pubmed ID: 30086304
Localization of RNAi Machinery to Axonal Branch Points and Growth Cones Is Facilitated by Mitochondria and Is Disrupted in ALS.
Frontiers in molecular neuroscience , 2018 | Pubmed ID: 30233312
Muscle secretion of toxic factors, regulated by miR126-5p, facilitates motor neuron degeneration in amyotrophic lateral sclerosis.
Neural regeneration research Jun, 2019 | Pubmed ID: 30762002
Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1 Model.
Cell death & disease 03, 2019 | Pubmed ID: 30824685
Structural Principles in Robo Activation and Auto-inhibition.
Cell 04, 2019 | Pubmed ID: 30853216
Patient-derived co-cultures for studying ALS.
Nature biomedical engineering 01, 2019 | Pubmed ID: 30932066
Efficient gene transfer into primary muscle cells to analyze nerve-independent postsynaptic organization in vitro.
Neuromuscular disorders : NMD 07, 2019 | Pubmed ID: 31230871
Single-Particle Diffusion Characterization by Deep Learning.
Biophysical journal Jul, 2019 | Pubmed ID: 31280841
Flow Arrest in the Plasma Membrane.
Biophysical journal Sep, 2019 | Pubmed ID: 31326106
An compartmental system underlines the contribution of mitochondrial immobility to the ATP supply in the NMJ.
Journal of cell science Dec, 2019 | Pubmed ID: 31722980
CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling.
EMBO reports Mar, 2020 | Pubmed ID: 31919978
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