Robert J. Vassar
Department of Neurology
Northwestern University Feinberg School of Medicine
Robert J. Vassar has not added Biography.
If you are Robert J. Vassar and would like to personalize this page please email our Author Liaison for assistance.
The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2009 | Pubmed ID: 19828790
BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization.
Molecular neurodegeneration Aug, 2010 | Pubmed ID: 20731874
The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease.
Alzheimer's research & therapy May, 2011 | Pubmed ID: 21639952
Elevated Aβ42 in aged, non-demented individuals with cerebral atherosclerosis.
Current Alzheimer research Oct, 2013 | Pubmed ID: 23919773
ADAM10 prodomain mutations cause late-onset Alzheimer's disease: not just the latest FAD.
Neuron Oct, 2013 | Pubmed ID: 24139026
Targeting the β secretase BACE1 for Alzheimer's disease therapy.
The Lancet. Neurology Mar, 2014 | Pubmed ID: 24556009
Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease.
Molecular neurodegeneration May, 2014 | Pubmed ID: 24885175
The normal and pathologic roles of the Alzheimer's β-secretase, BACE1.
Current Alzheimer research , 2014 | Pubmed ID: 24893886
Molecular neurodegeneration: basic biology and disease pathways.
Molecular neurodegeneration Sep, 2014 | Pubmed ID: 25248568
Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level.
Molecular neurodegeneration Jan, 2015 | Pubmed ID: 25567526
Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease.
Acta neuropathologica 08, 2016 | Pubmed ID: 26993139
Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.
Neuroscience and biobehavioral reviews Jun, 2016 | Pubmed ID: 27044452
Seeds of Destruction: New Mechanistic Insights into the Role of Apolipoprotein E4 in Alzheimer's Disease.
Neuron 12, 2017 | Pubmed ID: 29216455
Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice.
Science translational medicine 09, 2018 | Pubmed ID: 30232227
ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease.
The Journal of biological chemistry 11, 2018 | Pubmed ID: 30315100
A promising, novel, and unique BACE1 inhibitor emerges in the quest to prevent Alzheimer's disease.
EMBO molecular medicine 11, 2018 | Pubmed ID: 30322841
Editorial: Implications for BACE1 Inhibitor Clinical Trials: Adult Conditional BACE1 Knockout Mice Exhibit Axonal Organization Defects in the Hippocampus.
The journal of prevention of Alzheimer's disease , 2019 | Pubmed ID: 30756113
Death by microglia.
The Journal of experimental medicine 11, 2019 | Pubmed ID: 31645368
Aβ-accelerated neurodegeneration caused by Alzheimer's-associated variant R1279Q is rescued by angiotensin system inhibition in mice.
Science translational medicine 09, 2020 | Pubmed ID: 32998969
Early detection and personalized medicine: Future strategies against Alzheimer's disease.
Progress in molecular biology and translational science , 2021 | Pubmed ID: 33453940
A promising new γ-secretase modulator for Alzheimer's disease.
The Journal of experimental medicine 04, 2021 | Pubmed ID: 33683299
The case for low-level BACE1 inhibition for the prevention of Alzheimer disease.
Nature reviews. Neurology 11, 2021 | Pubmed ID: 34548654
JoVEについて
Copyright © 2023 MyJoVE Corporation. All rights reserved