Robert J. Vassar

The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential.

BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization.

The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease.

Elevated Aβ42 in aged, non-demented individuals with cerebral atherosclerosis.

ADAM10 prodomain mutations cause late-onset Alzheimer's disease: not just the latest FAD.

Targeting the β secretase BACE1 for Alzheimer's disease therapy.

Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease.

The normal and pathologic roles of the Alzheimer's β-secretase, BACE1.

Molecular neurodegeneration: basic biology and disease pathways.

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level.

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease.

Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.

Seeds of Destruction: New Mechanistic Insights into the Role of Apolipoprotein E4 in Alzheimer's Disease.

Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice.

ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease.

A promising, novel, and unique BACE1 inhibitor emerges in the quest to prevent Alzheimer's disease.

Editorial: Implications for BACE1 Inhibitor Clinical Trials: Adult Conditional BACE1 Knockout Mice Exhibit Axonal Organization Defects in the Hippocampus.

Death by microglia.

Aβ-accelerated neurodegeneration caused by Alzheimer's-associated variant R1279Q is rescued by angiotensin system inhibition in mice.

Early detection and personalized medicine: Future strategies against Alzheimer's disease.

A promising new γ-secretase modulator for Alzheimer's disease.

The case for low-level BACE1 inhibition for the prevention of Alzheimer disease.