Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.

The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.

The pharmacokinetic phase follows, detailing how the body absorbs, distributes, metabolizes, and excretes the drug post-administration. This phase provides valuable insights into the physiological processing of drugs.

In the pharmacodynamic phase, the focus shifts to the drug's interaction with its target, which could be receptors, ion channels, enzymes, or transporters. This phase elucidates the relationship between drug concentration and its effect, shedding light on potential therapeutic or toxic impacts.

The final therapeutic phase translates these pharmacological effects into clinical outcomes. It assesses how the drug's interaction with the target—either by inhibiting or activating it—can alleviate disease symptoms. As a result, this comprehensive four-phase process ensures the development of efficacious and safe drugs.

章から 3:

article

Now Playing

3.1 : Drug Administration and Therapy Phases: Overview

Pharmacokinetics: Drug Absorption

190 閲覧数

article

3.2 : 薬物吸収:概要

Pharmacokinetics: Drug Absorption

278 閲覧数

article

3.3 : ドラッグデリバリー:概要

Pharmacokinetics: Drug Absorption

155 閲覧数

article

3.4 : ドラッグデリバリー:経腸経路

Pharmacokinetics: Drug Absorption

146 閲覧数

article

3.5 : ドラッグデリバリー:非経口経路

Pharmacokinetics: Drug Absorption

114 閲覧数

article

3.6 : ドラッグデリバリー:その他のルート

Pharmacokinetics: Drug Absorption

110 閲覧数

article

3.7 : 細胞膜と薬物輸送

Pharmacokinetics: Drug Absorption

114 閲覧数

article

3.8 : 薬物吸収のメカニズム:傍細胞、経細胞、および小胞輸送

Pharmacokinetics: Drug Absorption

188 閲覧数

article

3.9 : パッシブ拡散:概要と動力学

Pharmacokinetics: Drug Absorption

144 閲覧数

article

3.10 : 細孔輸送とイオン対輸送

Pharmacokinetics: Drug Absorption

207 閲覧数

article

3.11 : キャリアを介した輸送

Pharmacokinetics: Drug Absorption

127 閲覧数

article

3.12 : 促進された拡散

Pharmacokinetics: Drug Absorption

150 閲覧数

article

3.13 : アクティブトランスポート

Pharmacokinetics: Drug Absorption

210 閲覧数

article

3.14 : 水疱性トラスポーツ:エンドサイトーシス、トランスサイトーシス、エキソサイトーシス

Pharmacokinetics: Drug Absorption

332 閲覧数

article

3.15 : 薬物吸収に影響を与える要因:解剖学的パラメータ

Pharmacokinetics: Drug Absorption

104 閲覧数

See More

JoVE Logo

個人情報保護方針

利用規約

一般データ保護規則

研究

教育

JoVEについて

Copyright © 2023 MyJoVE Corporation. All rights reserved