Anmelden

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.

The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.

The pharmacokinetic phase follows, detailing how the body absorbs, distributes, metabolizes, and excretes the drug post-administration. This phase provides valuable insights into the physiological processing of drugs.

In the pharmacodynamic phase, the focus shifts to the drug's interaction with its target, which could be receptors, ion channels, enzymes, or transporters. This phase elucidates the relationship between drug concentration and its effect, shedding light on potential therapeutic or toxic impacts.

The final therapeutic phase translates these pharmacological effects into clinical outcomes. It assesses how the drug's interaction with the target—either by inhibiting or activating it—can alleviate disease symptoms. As a result, this comprehensive four-phase process ensures the development of efficacious and safe drugs.

Aus Kapitel 3:

article

Now Playing

3.1 : Drug Administration and Therapy Phases: Overview

Pharmacokinetics: Drug Absorption

346 Ansichten

article

3.2 : Drug Absorption: Overview

Pharmacokinetics: Drug Absorption

408 Ansichten

article

3.3 : Drug Delivery: Overview

Pharmacokinetics: Drug Absorption

225 Ansichten

article

3.4 : Drug Delivery: Enteral Route

Pharmacokinetics: Drug Absorption

295 Ansichten

article

3.5 : Drug Delivery: Parenteral Route

Pharmacokinetics: Drug Absorption

297 Ansichten

article

3.6 : Drug Delivery: Miscellaneous Routes

Pharmacokinetics: Drug Absorption

258 Ansichten

article

3.7 : Cellular Membranes and Drug Transport

Pharmacokinetics: Drug Absorption

200 Ansichten

article

3.8 : Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

Pharmacokinetics: Drug Absorption

265 Ansichten

article

3.9 : Passive Diffusion: Overview and Kinetics

Pharmacokinetics: Drug Absorption

245 Ansichten

article

3.10 : Pore Transport and Ion-Pair Transport

Pharmacokinetics: Drug Absorption

263 Ansichten

article

3.11 : Carrier-Mediated Transport

Pharmacokinetics: Drug Absorption

177 Ansichten

article

3.12 : Facilitated Diffusion

Pharmacokinetics: Drug Absorption

223 Ansichten

article

3.13 : Active Transport

Pharmacokinetics: Drug Absorption

296 Ansichten

article

3.14 : Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis

Pharmacokinetics: Drug Absorption

473 Ansichten

article

3.15 : Factors Influencing Drug Absorption: Anatomical Parameters

Pharmacokinetics: Drug Absorption

132 Ansichten

See More

JoVE Logo

Datenschutz

Nutzungsbedingungen

Richtlinien

Forschung

Lehre

ÜBER JoVE

Copyright © 2025 MyJoVE Corporation. Alle Rechte vorbehalten