S'identifier

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.

The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.

The pharmacokinetic phase follows, detailing how the body absorbs, distributes, metabolizes, and excretes the drug post-administration. This phase provides valuable insights into the physiological processing of drugs.

In the pharmacodynamic phase, the focus shifts to the drug's interaction with its target, which could be receptors, ion channels, enzymes, or transporters. This phase elucidates the relationship between drug concentration and its effect, shedding light on potential therapeutic or toxic impacts.

The final therapeutic phase translates these pharmacological effects into clinical outcomes. It assesses how the drug's interaction with the target—either by inhibiting or activating it—can alleviate disease symptoms. As a result, this comprehensive four-phase process ensures the development of efficacious and safe drugs.

Du chapitre 3:

article

Now Playing

3.1 : Drug Administration and Therapy Phases: Overview

Pharmacokinetics: Drug Absorption

355 Vues

article

3.2 : Drug Absorption: Overview

Pharmacokinetics: Drug Absorption

419 Vues

article

3.3 : Drug Delivery: Overview

Pharmacokinetics: Drug Absorption

225 Vues

article

3.4 : Drug Delivery: Enteral Route

Pharmacokinetics: Drug Absorption

302 Vues

article

3.5 : Drug Delivery: Parenteral Route

Pharmacokinetics: Drug Absorption

299 Vues

article

3.6 : Drug Delivery: Miscellaneous Routes

Pharmacokinetics: Drug Absorption

258 Vues

article

3.7 : Cellular Membranes and Drug Transport

Pharmacokinetics: Drug Absorption

211 Vues

article

3.8 : Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

Pharmacokinetics: Drug Absorption

271 Vues

article

3.9 : Passive Diffusion: Overview and Kinetics

Pharmacokinetics: Drug Absorption

263 Vues

article

3.10 : Pore Transport and Ion-Pair Transport

Pharmacokinetics: Drug Absorption

273 Vues

article

3.11 : Carrier-Mediated Transport

Pharmacokinetics: Drug Absorption

198 Vues

article

3.12 : Facilitated Diffusion

Pharmacokinetics: Drug Absorption

234 Vues

article

3.13 : Active Transport

Pharmacokinetics: Drug Absorption

319 Vues

article

3.14 : Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis

Pharmacokinetics: Drug Absorption

488 Vues

article

3.15 : Factors Influencing Drug Absorption: Anatomical Parameters

Pharmacokinetics: Drug Absorption

135 Vues

See More

JoVE Logo

Confidentialité

Conditions d'utilisation

Politiques

Recherche

Enseignement

À PROPOS DE JoVE

Copyright © 2025 MyJoVE Corporation. Tous droits réservés.