Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase follows, detailing how the body absorbs, distributes, metabolizes, and excretes the drug post-administration. This phase provides valuable insights into the physiological processing of drugs.
In the pharmacodynamic phase, the focus shifts to the drug's interaction with its target, which could be receptors, ion channels, enzymes, or transporters. This phase elucidates the relationship between drug concentration and its effect, shedding light on potential therapeutic or toxic impacts.
The final therapeutic phase translates these pharmacological effects into clinical outcomes. It assesses how the drug's interaction with the target—either by inhibiting or activating it—can alleviate disease symptoms. As a result, this comprehensive four-phase process ensures the development of efficacious and safe drugs.
Bölümden 3:
Now Playing
Pharmacokinetics: Drug Absorption
346 Görüntüleme Sayısı
Pharmacokinetics: Drug Absorption
408 Görüntüleme Sayısı
Pharmacokinetics: Drug Absorption
225 Görüntüleme Sayısı
Pharmacokinetics: Drug Absorption
295 Görüntüleme Sayısı
Pharmacokinetics: Drug Absorption
297 Görüntüleme Sayısı
Pharmacokinetics: Drug Absorption
258 Görüntüleme Sayısı
Pharmacokinetics: Drug Absorption
200 Görüntüleme Sayısı
Pharmacokinetics: Drug Absorption
265 Görüntüleme Sayısı
Pharmacokinetics: Drug Absorption
245 Görüntüleme Sayısı
Pharmacokinetics: Drug Absorption
263 Görüntüleme Sayısı
Pharmacokinetics: Drug Absorption
177 Görüntüleme Sayısı
Pharmacokinetics: Drug Absorption
223 Görüntüleme Sayısı
Pharmacokinetics: Drug Absorption
296 Görüntüleme Sayısı
Pharmacokinetics: Drug Absorption
473 Görüntüleme Sayısı
Pharmacokinetics: Drug Absorption
132 Görüntüleme Sayısı
See More
JoVE Hakkında
Telif Hakkı © 2020 MyJove Corporation. Tüm hakları saklıdır