著者はこのプロトコルで使用される振動子の振動周波数を確認する分析を実施するためジョン ・ ネルソン博士は、PT を認めたいと思います。

カレッジ オブ セント スコラスティカので制度検討委員会が、このプロトコルが開発およびテストの研究を承認します。
注: このプロトコルで使用される振動子の製造元の仕様を示した '高' の周波数 11,00 rpm (183.3 Hz)。この周波数は 2 kHz でサンプリング差動増幅回路の 1 つの入力を通じて収集した振動データのサンプルを使用して確認されました。信号の平均期間は 5.56 × 10-3 s 180 Hz に相当します。レイノー病を持つ個人で振動は、レイノー現象、最後数分から数時間としびれ、かゆみや痛みを伴うことがありますアプリケーションのサイトに一時的な血管収縮を引き起こす可能性があります。23図 1は、このプロトコルで用いられている類似の振動によるレイノー現象の例を示します。潜在的な参加者は、このプロトコルに参加する前にレイノーにスクリーニングする必要があります。
1. 感覚ノックダウン プロトコル:
<ol><li>ペン、183 Hz バイブレーター、2.5 インチ幅のストラップ、ゴムバンドを収集 (材料の表を参照してください)。</li>
	<li>テストされている上肢の尺骨溝の中で尺骨神経を触診します。<ol>
<li>"X"マーク皮膚上に配置尺骨溝上上腕骨の肘頭突起と内側上顆、尺骨の間の線にだけ優れています。 注:図 2肘の背部のこの場所を示しています。</li>
	</ol>
</li>
	<li>頭に優れたマッサー ジャーのハンドルとマークされた場所に振動子の頭を配置します。<ol>
<li>バイブレーターと参加者の腕のハンドル部分を囲む広いストラップを適用します。</li>
		<li>バイブレーターの頭の場所に振動子の頭を押しながら参加者の肌とゴムバンドが皮膚に対してはなく、頭を保持する適切なサイズであることを確認、バイブレーター ヘッド間の接触を維持する参加者の腕の首の周りのゴムバンドを配置します。運動や循環を制限します。</li>
	</ol>
</li>
	<li>曲げるし、彼/彼女の肘をまっすぐに参加者を求めます。彼/彼女はストラップからの干渉を感じるはずです。彼/彼女は干渉を報告、移動の自由が保障されるので、ストラップ、ゴムバンドを調整します。</li>
	<li>高振動をオン、(未発表のデータに基づいて) 2 分待ちます。<ol>
<li>感覚性能の測定を実施 (BKT のタブレットのバージョンからの結果はここで発表会) 高上テストの期間で実行するバイブレーターで<ol>
<li>BKT を実施します。遮蔽幕を利用したタブレットから彼らのビジョンと標準の高さテーブル (29 インチの高さ) でシートの標準の高さの椅子 (18 インチ シート高) に参加。参加者の向かいに座っています。</li>
			<li>行の先頭に戻る (ターゲット) の行の末尾に行の先頭から末節のみ、開催参加者人差し指をガイドします。参加者の指を解放し、ターゲットに触れないようにそれらに指示します。各上肢 20 試験を完了します。</li>
			<li>センチメートル単位の平均絶対誤差 (ターゲットからの距離) として各上肢の参加者のスコアを割り当てます。</li>
		</ol>
</li>
		<li>振動刺激の除去時にすぐに心理物理学的測定 (VDT) などを実施します。 注: 示された結果、VDT の前に振動刺激の期間年 5 ± 1 分。</li>
	</ol>
</li>
</ol>2. 振動覚閾値 (13から適応)
<ol><li>収集 128 Hz 音叉、ストップウォッチ、教科書 (チューニング フォークを攻撃するために会社はまだ準拠してサーフェイスを提供します)、テーブル (29 インチの高さ)、標準的な椅子 (18 インチ シート高)、マスキング テープ、ペン。<ol>
<li>マスキング テープを使用して印象的な音叉で一貫性のターゲットとして使用する教科書に 1 ½ インチ x 1 1/2 のインチの正方形を作成します。</li>
		<li>永久的なマーカー、色 1 mm チューニング フォーク (音叉テスト中にアプリケーションの圧力を標準化するこのマークが使用されます) の幹の下部を使用します。</li>
		<li>テーブルで椅子に参加者を座席します。前腕回外テストされている下肢を拡張し、完全に肘を含むテーブルに置かにお問い合わせください。四肢をリラックスしてもらいます。 注: 審査官に参加者の向かいに座るべきです。</li>
	</ol>
</li>
	<li>遠位上腕二頭筋腱、肘のしわに優れた約 1 センチメートル以上皮膚にドットをマークします。<ol>
<li>参加者は、参加者の肘の間に最も近いテーブルの端に本を置きます。</li>
		<li>言う:「これは振動を検出する能力のテストです。今私は上腕二頭筋腱にこの音叉を置きます。任意の振動を感じるし、振動の感覚が消滅した場合、すぐに「今すぐ」と言う場合私に教えてください。この手順が繰り返される 3 回各アームの。」</li>
	</ol>
</li>
	<li>チューニング フォークの各ピンの端にディスクを開始する前にタイトなことを確認します。彼らが緩んでいる場合、彼らはガラガラ、音叉の共鳴の信頼性テストを作る期間を短縮します。<ol>
<li>親指と人差し指の間に緩く音叉の幹を押しながら共鳴を引き起こすのに十分な力を持つ正方形ターゲット中の本にストライクします。<ol>
<li>印象的な直後に皮膚を抑制し、ビジョンから音叉の 1 mm バンドを隠すため十分な圧力を使用して、テスト用の場所に音叉を配置します。 注:図 3は、音叉型遠位上腕二頭筋腱テスト用のこのプロトコルで使われる場所です。</li>
			<li>参加者は、もはや ('今' を言う) 振動を感じるまで、参加者の肌に音叉の配置から時間を定量化するストップウォッチを使用して。</li>
		</ol>
</li>
		<li>3 つの試験の合計は同じ腕にさらに 2 回を繰り返します。<ol>
<li>振動検出しきい値 (VDT) を決定する 3 つの試験の間で振動刺激の消失までの平均値を計算します。</li>
		</ol>
</li>
	</ol>
</li>
</ol>

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著者が明らかに何もありません。

このプロトコルは、上肢の人間感覚をノックダウンするメソッドを提供します。20 健康参加者間で感覚のノックダウンの効果は VDT の核内局在求心性軸索伝送を反映すると考え感度の心理物理学的測定によって測定される大規模です。VDT は核内局在求心性放電時の振動の除去が減少した後、できるだけ早く測定しました。25エラーの visual 咬合 (tBKT) ターゲットに到達するこ?...

運動の神経制御するすべての貢献者の感覚が少なくともも測定した可能性があります。専門機器を使用しての固有感覚の研究対策は最近精度、妥当性、信頼性を達成しています。1,2,3コントラスト、固有感覚、四肢の位置感覚テスト最も一般的なされている、4の臨床的指標で低解像度、他の感覚モダリティ、4が汚染されているし、貧しい人々 またはパブリッシュされた心理プロパティはありません。5感覚コントロール、3障害の臨床診断のための末梢および中枢のメカニズムを明らかにし、感覚のトレーニングの成果を測定するため、固有感覚の新しい正確な信頼できる対策が必要です。2,5,6,7この年末に向けて一時的に阻害する簡単な非侵襲的方法または 'ノックダウン' 感覚が必要です。
健康な人間の感覚のノックダウンでは、研究開発および標準化された対策の検証に通知するときに便利です感覚運動タスクにおける受容機能の役割を推測することができます。ノックダウン モデル固有感覚障害を持つ人間を勉強して 2 つの主要な利点があります。最初は参加者の可用性深部感覚障害を持つ個人は、多くの研究者に簡単にアクセスできません。第二に、固有感覚障害体内とは異なり、ノックダウン モデル参加者間で障害の程度を制御することができます。
上部の肢の一時的な感覚のノックダウンの現在の公開メソッドは侵襲的な非現実的なまたは参加者の不快です。麻酔注射中比較的安全で技術的な専門知識を必要とする、いくつかの研究の参加者によって侵襲的考慮されるかもしれない。虚血性の神経ブロックは、不快感を引き起こすし、凝固障害の申請の前に、画面を血液検査を練習しました。8凍結療法も不快感を引き起こします。感覚に影響する凍結療法のアプリケーションの平均時間は 20.3 ± 5.3 分9凍結療法を取り外したら、加温前に感覚を測定する簡単なウィンドウのままの矛盾した効果に貢献するかもしれない関節位置覚に凍結療法。10高周波数 (300 Hz) の振動は、指の動きの検出タスクの固有感覚視力を減らすために正常に使用されました。機構は、パチニ小体 - 他の振動敏感な皮膚受容器からの入力の抑制をすると報じられました。11最近、ヒラメ筋振動 (80 Hz) が固有感覚情報を歪めることによって精度が等尺性力を減少する見つかりました。12ただし、単純な非侵襲的上肢感覚の一時的なノックダウン法は公開されていません。
このメソッドの目的は、健常成人における一時的にノックダウン上肢の深部に高周波振動を使用することです。ノックダウンは、2 つの対策、振動検出しきい値 (VDT) と簡単な運動感覚テスト (tBKT) のタブレットのバージョンを使用して確認されました。VDT は核内局在求心性軸索伝送を反映すると考え感度の心理物理学的測定です。13感覚性能の私たちの研究室で開発中である tBKT を使用して定量化を行った。簡単な運動感覚テスト (BKT)、エアーズの仕事に基づいて14はのテストだった、国立衛生研究所 (NIH) ツールボックス コア電池含まれていない実験装置です。15,16 にはBKT には各上肢到達 3 つの試験が含まれています。TBKT 上肢あたり 20 到達試験が含まれています、オリジナル テストで計量心理学的特性を向上させる目的で開発中です。TBKT を含む感覚入力 (ターゲットに上肢の審査指導)、中央処理 (対象の空間的位置を覚えている) (指導が削除された後に、ターゲットを見つけようとしている)、モーター出力の測定で必要になると考え全体的な感覚パフォーマンス。17 VDT と tBKT の測定値18 、体性感覚の階層でそれぞれ、低および高レベルを表す、従ってどちらかの措置を単独で使用するよりも感覚のより包括的な定量化を提供する必要があります。
2 つの神経機構は、高周波振動によって引き起こされる減らされた感覚視力に最も密接に関連します。まず、パチニ小体は振動検知と関連付けられる最も一般的皮膚の受容です。このプロトコル可能性がありますで使用される連続的な振動は、核内局在で短期的な慣れの神経機構に基づく振動検出の β 繊維グループ パチニ小体に関連する受容体調整しきい値を発生させます。19生理学的結果は短い持続期間のための同じ強度と VDT テストで使用されている 128 Hz など周波数の振動を感じたことです。第二に、それは核内局在求心性線維を介して、筋紡錘が筋肉の長さを正確に高周波振動力再生、12時に減らされた正確さによって証明されるように歪んだ感覚情報の結果に従うをコードと考えられる動き、20,21 ・削減運動覚のような錯覚。22

<table><tbody><tr><td>Pure Enrichment-Massage Mini with Built in USB Rechargeable Battery</td><td>ebay</td><td>None</td><td>183 Hz cordless vibrator, 7 inches total length including handle</td></tr><tr><td>Chattanooga 2.5 inch velcro strap&amp;nbsp;</td><td>ebay</td><td>None</td><td>used to secure vibrator to arm</td></tr><tr><td>Tuning Fork C128 ENT Surgical Medical Instruments Exam Diagnostic Tools</td><td>ebay</td><td>None</td><td>Used in VDT</td></tr><tr><td>Handheld Digital stop watch</td><td>ebay</td><td>None</td><td>Used to time VDT</td></tr><tr><td>Universal Rubber Bands Size 33, 3 1/2 x 1/8 inch</td><td>ebay</td><td>Universal - UNV00433</td><td>used to secure vibrator head to arm</td></tr><tr><td>Instructions to build Visual Screen were published here: https://www.jove.com/video/53178/design-fabrication-administration-hand-active-sensation-test&amp;nbsp;</td><td></td><td></td><td></td></tr></tbody></table>

a simple non-invasive method for temporary knockdown of upper limb proprioception

感覚運動の神経制御へすべての貢献者の少なくともも測定があります。感覚の訓練の成果を測定する障害の臨床診断感覚の新しい正確な信頼できる対策が必要です。この簡単な非侵襲的方法の目的は、一時的にノックダウン上肢受容と上肢感覚対策のテストの開発に役立つと思われる程度の健康な成人にです。ノックダウン モデル固有感覚障害を持つ人間を勉強して 2 つの主要な利点がある: 参加者の可用性と参加者間で障害の程度を制御する機能。虚血性の神経ブロックや、凍結療法など、上肢の一時的な感覚ノックダウンの現在の公開メソッドは侵襲的、実用的ではない、または参加者の不快。ここでは、尺骨溝に振動は上肢の感覚を減らすために使用されました。高周波振動は、パチニ小体による入力を抑制することによって感覚視力を減らすことができます。このプロトコルで使われる振動の影響は、2 つの定量的な対策を使用して確認されました。このメソッドは、管理も単純に、参加者は、快適で実用的なだった。

ここで提示されたプロトコルを使用して、我々 はテスト健康成人 20 名、8 名が男性 (平均年齢 (SD) = 32.5 (12.5) 年; 19 右・左 1 - 左利き)。参加者には、上肢を含む既知の病変はなかった。利き手は、エジンバラのラテラリティを使用して査定されました。24研究参加者には、有害事象を報告されません。
各?...

Watch this Scientific Journal Video about A Simple Non-invasive Method for Temporary Knockdown of Upper Limb Proprioception at JoVE.com

A Simple Non-invasive Method for Temporary Knockdown of Upper Limb Proprioception

このプロトコルの目的は、健康な人間の上肢の感覚を一時的に妨害する実用的な方法を示すことです。

単純な非侵襲的上肢感覚の一時的なノックダウン法

Proprioception may be the least well measured of all contributors to the neural control of movement. New precise, reliable measures of proprioception are ...

a-simple-non-invasive-method-for-temporary-knockdown-upper-limb

Research

JoVE Journal

Behavior

9.4K ビュー.  The College of St. Scholastica. このプロトコルの目的は、健康な人間の上肢の感覚を一時的に妨害する実用的な方法を示すことです。

ビデオ: A Simple Non-invasive Method for Temporary Knockdown of Upper Limb Proprioception

Functional Near Infrared Spectroscopy of the Sensory and Motor Brain Regions with Simultaneous Kinematic and EMG Monitoring During Motor Tasks

There are several advantages that functional near-infrared spectroscopy (fNIRS) presents in the study of the neural control of human movement. It is relatively flexible with respect to participant positioning and allows for some head movements during tasks. Additionally, it is inexpensive, light weight, and portable, with very few contraindications to its use. This presents a unique opportunity to study functional brain activity during motor tasks in individuals who are typically developing, as well as those with movement disorders, such as cerebral palsy. An additional consideration when studying movement disorders, however, is the quality of actual movements performed and the potential for additional, unintended movements. Therefore, concurrent monitoring of both blood flow changes in the brain and actual movements of the body during testing is required for appropriate interpretation of fNIRS results. Here, we show a protocol for the combination of fNIRS with muscle and kinematic monitoring during motor tasks. We explore gait, a unilateral multi-joint movement (cycling), and two unilateral single-joint movements (isolated ankle dorsiflexion, and isolated hand squeezing). The techniques presented can be useful in studying both typical and atypical motor control, and can be modified to investigate a broad range of tasks and scientific questions.

Monitoring brain activity during upright motor tasks is of great value when investigating the neural source of movement disorders. Here, we demonstrate a protocol that combines functional near infrared spectroscopy with continuous monitoring of muscle and kinematic activity during 4 types of motor tasks.

運動課題中に同時キネマとEMGの監視と感覚運動の脳領域の機能的近赤外分光法

There are several advantages that functional near-infrared spectroscopy (fNIRS) presents in the study of the neural control of human movement. It is ...

行動学

The Knob Supination Task: A Semi-automated Method for Assessing Forelimb Function in Rats

Tasks that accurately measure dexterity in animal models are critical to understand hand function. Current rat behavioral tasks that measure dexterity largely use video analysis of reaching or food manipulation. While these tasks are easy to implement and are robust across disease models, they are subjective and laborious for the experimenter. Automating traditional tasks or creating new automated tasks can make the tasks more efficient, objective, and quantitative. Since rats are less dexterous than primates, central nervous system (CNS) injury produces more subtle deficits in dexterity, however, supination is highly affected in rodents and crucial to hand function in primates. Therefore, we designed a semi-automated task that measures forelimb supination in rats. Rats are trained to reach and grasp a knob-shaped manipulandum and turn the manipulandum in supination to receive a reward. Rats can acquire the skill within 20 &plusmn; 5 days. While the early part of training is highly supervised, much of the training is done without direct supervision. The task reliably and reproducibly captures subtle deficits after injury and shows functional recovery that accurately reflects clinical recovery curves. Analysis of data is performed by specialized software through a graphical user interface that is designed to be intuitive. We also give solutions to common problems encountered during training, and show that minor corrections to behavior early in training produce reliable acquisition of supination. Thus, the knob supination task provides efficient and quantitative evaluation of a critical movement for dexterity in rats.

This manuscript describes a semi-automated task that quantifies supination in rats. Rats reach, grasp, and supinate a spherical manipulandum. The rat is rewarded with a pellet if the turn angle exceeds a criterion set by the user. This task increases throughput, sensitivity to injury, and objectivity compared to traditional tasks.

ノブ外タスク: ラットの前肢関数を評価するための半自動メソッド

Tasks that accurately measure dexterity in animal models are critical to understand hand function. Current rat behavioral tasks that measure dexterity ...

A Standardized Method for Measurement of Elbow Kinesthesia

Proprioception is an important component of controlled movement. The threshold to detection of passive movement (TDPM) is a commonly used method for quantifying the proprioceptive submodality of kinesthesia in research settings. The TDPM paradigm has been found to be valid and reliable; however, the equipment and methods used for TDPM vary between studies. In particular, the research laboratory apparatuses for producing passive movement of an extremity are often custom designed by individual laboratories or inaccessible due to high cost. There is a need for a standardized, valid, and reliable method for measuring TDPM using readily available equipment. The purpose of this protocol is to provide a standardized method for measurement of TDPM at the elbow that is economical, easy to administer, and that produces quantitative results for measurement purposes in research-based settings. This method was tested on 20 healthy adults without neurological impairment, and eight adults with chronic stroke. The results obtained suggest this method is a reliable way to quantify elbow TDPM in healthy adults, and provides initial support for validity. Researchers seeking a balance between equipment affordability and measurement precision are most likely to find this protocol of benefit.

Here, we present a standardized method for measurement of elbow passive kinesthesia using the threshold to detection of passive movement (TDPM) that is appropriate for a research setting.

エルボー運動症の測定のための標準化された方法

Proprioception is an important component of controlled movement. The threshold to detection of passive movement (TDPM) is a commonly used method for ...

Measuring Contralateral Silent Period Induced by Single-Pulse Transcranial Magnetic Stimulation to Investigate M1 Corticospinal Inhibition

Contralateral silent period (cSP) is a period of suppression in the background electrical muscle activity captured by electromyography (EMG) after a motor evoked potential (MEP). To obtain this, an MEP is elicited by a suprathreshold transcranial magnetic stimulation (TMS) pulse delivered to the primary motor cortex (M1) of the target muscle selected, while the participant provides a standardized voluntary target muscle contraction. The cSP is a result of inhibitory mechanisms that occur after the MEP; it provides a broad temporal assessment of spinal inhibition in its initial ~50 ms, and cortical inhibition after. Researchers have tried to better understand the neurobiological mechanism behind the cSP to validate it as a potential diagnostic, surrogate, and predictive biomarker for different neuropsychiatric diseases. Therefore, this article describes a method to measure M1 cSP of lower and upper limbs, including a selection of target muscle, electrode placement, coil positioning, method of measuring voluntary contraction stimulation, intensity setup, and data analysis to obtain a representative result. It has the educational objective of giving a visual guideline in performing a feasible, reliable, and reproducible cSP protocol for lower and upper limbs and discussing practical challenges of this technique.

Contralateral silent period (cSP) assessment is a promising biomarker to index cortical excitability and treatment response. We demonstrate a protocol to assess cSP intended for studying M1 corticospinal inhibition of upper and lower limbs.

M1皮質脊髄抑制の検討のための単一パルス経頭蓋磁気刺激による対側沈黙期間の測定

Contralateral silent period (cSP) is a period of suppression in the background electrical muscle activity captured by electromyography (EMG) after a motor ...

神経科学

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Nociceptors are a class of primary afferent neurons that signal potentially harmful noxious stimuli. An increase in nociceptor excitability occurs in acute and chronic pain conditions. This produces abnormal ongoing activity or reduced activation thresholds to noxious stimuli. Identifying the cause of this increased excitability is required for the development and validation of mechanism-based treatments. Single-neuron electrical threshold tracking can quantify nociceptor excitability. Therefore, we have developed an application to allow such measurements and demonstrate its use in humans and rodents. APTrack provides real-time data visualization and action potential identification using a temporal raster plot. Algorithms detect action potentials by threshold crossing and monitor their latency after electrical stimulation. The plugin then modulates the electrical stimulation amplitude using an up-down method to estimate the electrical threshold of the nociceptors. The software was built upon the Open Ephys system (V0.54) and coded in C++ using the JUCE framework. It runs on Windows, Linux, and Mac operating systems. The open-source code is available (<a data-saferedirecturl="https://www.google.com/url?q=https://github.com/Microneurography/APTrack&amp;source=gmail&amp;ust=1680789829274000&amp;usg=AOvVaw0nMk9J_EI2jUn8SlmC5JJm" href="https://github.com/Microneurography/APTrack" target="_blank">https://github.com/Microneurography/APTrack</a>). The electrophysiological recordings were taken from nociceptors in both a mouse skin-nerve preparation using the teased fiber method in the saphenous nerve and in healthy human volunteers using microneurography in the superficial peroneal nerve. Nociceptors were classified by their response to thermal and mechanical stimuli, as well as by monitoring the activity-dependent slowing of the conduction velocity. The software facilitated the experiment by simplifying the action potential identification through the temporal raster plot. We demonstrate real-time closed-loop electrical threshold tracking of single-neuron action potentials during&#160;in vivo&#160;human microneurography, for the first time, and during&#160;ex vivo&#160;mouse electrophysiological recordings of C-fibers and A&#948;-fibers. We establish proof of principle by showing that the electrical threshold of a human heat-sensitive C-fiber nociceptor is reduced by heating the receptive field. This plugin enables the electrical threshold tracking of single-neuron action potentials and allows the quantification of changes in nociceptor excitability.

APTrack is a software plugin developed for the Open Ephys platform that enables real-time data visualization and the closed-loop electrical threshold tracking of neuronal action potentials. We have successfully used this in microneurography for human C-fiber nociceptors and mouse C-fiber and A&#948;-fiber nociceptors.

トランスレーショナルペイン研究のためのオープンソースのリアルタイム閉ループ電気閾値追跡

Nociceptors are a class of primary afferent neurons that signal potentially harmful noxious stimuli. An increase in nociceptor excitability occurs in ...

遠隔経頭蓋直流刺激による幻肢痛の治療

Using Home-based, Remotely Supervised, Transcranial Direct Current Stimulation for Phantom Limb Pain

Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that uses low-amplitude direct currents to alter cortical excitability. Previous trials have established the safety and tolerability of tDCS, and its potential to mitigate symptoms. However, the effects are cumulative, making it more difficult to have adherence to the treatment since frequent visits to the clinic or outpatient center are required. Moreover, the time needed for transportation to the center and the related expenses limit the accessibility of the treatment for many participants.
Following guidelines for remotely supervised transcranial direct current stimulation (RS-tDCS) implementation, we propose a protocol designed for remotely supervised and home-based participation that uses specific devices and materials modified for patient use, with real-time monitoring by researchers through an encrypted video conferencing platform. We have developed detailed instructional materials and structured training procedures to allow for self- or proxy-administration while supervised remotely in real time. This protocol has a specific design to have a series of checkpoints during training and execution of the visit. This protocol is currently in use in a large pragmatic study of RS-tDCS for phantom limb pain (PLP). In this article, we will discuss the operational challenges of conducting a home-based RS-tDCS session and show methods to enhance its efficacy with supervised sessions.

著者スポットライト:幻肢痛に対する遠隔教師付きニューロモデュレーション手順への洞察

The goal of this study is to describe a protocol for the home-based delivery of remotely supervised transcranial direct current stimulation (RS-tDCS) conserving the standard procedures of in-clinic practice, including safety, reproducibility, and tolerability. The participants included will be patients with phantom limb pain (PLP).

幻肢痛に対する在宅遠隔監視経頭蓋直流刺激の使用

Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that uses low-amplitude direct currents to alter cortical ...

An Experimental Approach to Induce Trips in Lower-Limb Amputees

Reestablishing balance after a trip is challenging for lower-limb amputees and often results in a fall. The effectiveness of reestablishing balance following a trip depends on factors such as amputation level (transtibial or transfemoral) or which limb is tripped (prosthetic or sound/lead or trailing). Understanding the recovery responses can help identify strategies to avoid a trip becoming a fall and what trip-response functionality could be designed into a prosthesis. This study presents an experimental approach for inducing unexpected trips in individuals with amputation. Tripping was manually triggered by activating an electromagnetic device to raisea polypropylene wire to obstruct (bring to a near halt) theswinging limb during its mid-swing phase. A safety harness attached to a ceiling rail ensured participants did not hit the ground if they failed to reestablish balance following the trip (i.e., it prevented a fall from occurring). One transtibial amputee completed repeated walking trials in which a trip was induced around 1 out of 15 times to avoid it being anticipated. 3D kinematics were determined via two smartphones (60Hz) using the OpenCap software, highlighting that the experimental approach induced meaningful tripping/recovery responses dependent on which limb was tripped (prosthetic or sound). The presented methodology avoids using a rigid obstacle, potentially reducing the risk of injuries, and is inexpensive and easy to set up. Importantly it permits a trip to be unexpectedly introduced during the mid-swing phase of the gait and hence provides an approach for identifying real-world trip recovery responses. When tripping the sound limb, participants could &#39;disentangle&#39; from the trip-wire (post-trip) by plantarflexing the ankle, but such action was not possible when tripping the prosthetic limb.

An experimental approach was developed to induce trips in lower-limb amputees. The goal was to create unexpected trips and induce meaningful tripping/recovery responses. The kinematic data from one transtibial amputee confirmed that such an approach effectively elicits reactive trip recovery responses.

Reestablishing balance after a trip is challenging for lower-limb amputees and often results in a fall. The effectiveness of reestablishing balance ...

医学

脳機能リモデリングを研究するための機能的OTおよび近赤外分光法

Investigating the Effect of Different Types of Exercise on Upper Limb Functional Recovery in Patients with Right Hemisphere Damage Based on fNIRS

To investigate the effects of functional occupational therapy (FOT) combined with different types of exercise on upper limb motor function recovery and brain function remodeling in patients with right hemisphere damage (RHD) by analyzing functional near-infrared spectroscopy (fNIRS). Patients (n = 32) with RHD at Beijing Bo'ai Hospital were recruited and randomly allocated to receive either FOT combined with passive motion (N=16) or FOT combined with assisted active movement (N=16). The passive motion group (FOT-PM) received functional occupational therapy for 20 min and passive exercise for 10 min in each session, while the assisted active movement group (FOT-AAM) received functional occupational therapy for 20 min and assisted active exercise for 10 min. Both groups received conventional drug therapy and other rehabilitation therapy. Treatment was performed once a day, 5 times a week for 4 weeks. The recovery of motor function and activities of daily living (ADL) was assessed using Fugl-Meyer Assessment upper extremity (FMA-UE) and modified Barthel index (MBI) before and after treatment, and brain activation of the bilateral motor area was analyzed with fNIRS. The findings suggested that FOT combined with AAM was more effective than FOT combined with PM in improving the motor function of RHD patients' upper limbs and fingers, improving their ability to perform activities of daily living, and facilitating brain function remodeling of the motor area.

著者スポットライト:補助アクティブエクササイズを使用した右半球損傷患者における上肢リハビリテーションの進歩

Here, we investigate the effect of functional occupational therapy combined with assisted active or passive motion on the upper limb function of patients with right hemisphere damage and explore the effect of functional near-infrared spectroscopy on brain function remodeling.

fNIRSに基づく右半球損傷患者の上肢機能回復に対するさまざまな種類の運動の影響の調査

To investigate the effects of functional occupational therapy (FOT) combined with different types of exercise on upper limb motor function recovery and ...

単純な非侵襲的上肢感覚の一時的なノックダウン法

要約

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この動画の章

運動課題中に同時キネマとEMGの監視と感覚運動の脳領域の機能的近赤外分光法

ノブ外タスク: ラットの前肢関数を評価するための半自動メソッド

エルボー運動症の測定のための標準化された方法

M1皮質脊髄抑制の検討のための単一パルス経頭蓋磁気刺激による対側沈黙期間の測定

トランスレーショナルペイン研究のためのオープンソースのリアルタイム閉ループ電気閾値追跡

幻肢痛に対する在宅遠隔監視経頭蓋直流刺激の使用

幻肢痛に対する在宅遠隔監視経頭蓋直流刺激の使用

幻肢痛に対する在宅遠隔監視経頭蓋直流刺激の使用

An Experimental Approach to Induce Trips in Lower-Limb Amputees

fNIRSに基づく右半球損傷患者の上肢機能回復に対するさまざまな種類の運動の影響の調査