Quantitative Biology
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Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors.
The Journal of pharmacology and experimental therapeutics Jul, 2002 | Pubmed ID: 12065741
(+)-Dinapsoline: an efficient synthesis and pharmacological profile of a novel dopamine agonist.
Journal of medicinal chemistry Aug, 2002 | Pubmed ID: 12166939
Diminished catalepsy and dopamine metabolism distinguish aripiprazole from haloperidol or risperidone.
European journal of pharmacology Jul, 2003 | Pubmed ID: 12860477
2-arylaminothiazoles as high-affinity corticotropin-releasing factor 1 receptor (CRF1R) antagonists: synthesis, binding studies and behavioral efficacy.
Bioorganic & medicinal chemistry letters Nov, 2003 | Pubmed ID: 14592493
Synthesis and SAR exploration of dinapsoline analogues.
Bioorganic & medicinal chemistry Feb, 2004 | Pubmed ID: 14759732
The novel antipsychotic aripiprazole is a partial agonist at short and long isoforms of D2 receptors linked to the regulation of adenylyl cyclase activity and prolactin release.
Brain research Apr, 2004 | Pubmed ID: 15019558
Mechanism of action of aripiprazole predicts clinical efficacy and a favourable side-effect profile.
Journal of psychopharmacology (Oxford, England) Sep, 2004 | Pubmed ID: 15358981
Aripiprazole's low intrinsic activities at human dopamine D2L and D2S receptors render it a unique antipsychotic.
European journal of pharmacology May, 2005 | Pubmed ID: 15894311
Synthesis, structure-activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists.
Bioorganic & medicinal chemistry letters Sep, 2005 | Pubmed ID: 15990298
Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT 2A receptors: functional receptor-binding and in vivo electrophysiological studies.
Psychopharmacology Feb, 2007 | Pubmed ID: 17242925
Oxime carbamate--discovery of a series of novel FAAH inhibitors.
Bioorganic & medicinal chemistry letters Feb, 2010 | Pubmed ID: 20036536
Design, synthesis and evaluation of constrained tetrahydroimidazopyrimidine derivatives as antagonists of corticotropin-releasing factor type 1 receptor (CRF1R).
Bioorganic & medicinal chemistry letters Mar, 2010 | Pubmed ID: 20185312
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