Department of Biological Sciences,
Center for Cancer,
Genetic Diseases and Gene Regulation,
Department of Biological Sciences, Center for Cancer, Genetic Diseases and Gene Regulation
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The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2002 | Pubmed ID: 11904436
Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors.
The EMBO journal Aug, 2003 | Pubmed ID: 12912913
Comment on 'Integrin alphavbbeta is not required for the phagocytosis of photoreceptor outer segments by cultured retinal pigment epithelial cells' by M.O. Hall, T.A. Abrams and B.L. Burgess [Exp. Eye Res. 77 (2003) 281-286].
Experimental eye research Feb, 2004 | Pubmed ID: 14729363
Role of alphavbeta5 integrin in regulating phagocytosis by the retinal pigment epithelium.
Advances in experimental medicine and biology , 2003 | Pubmed ID: 15180282
Changes in retinal pigment epithelial gene expression induced by rod outer segment uptake.
Investigative ophthalmology & visual science Jul, 2004 | Pubmed ID: 15223782
Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin.
The Journal of experimental medicine Dec, 2004 | Pubmed ID: 15596525
Nonsynaptic localization of the excitatory amino acid transporter 4 in photoreceptors.
Molecular and cellular neurosciences Mar, 2005 | Pubmed ID: 15737735
Novel role for alphavbeta5-integrin in retinal adhesion and its diurnal peak.
American journal of physiology. Cell physiology Apr, 2006 | Pubmed ID: 16338970
Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: a potential mechanism for modulating outer segment phagocytosis under oxidant stress conditions.
The Journal of biological chemistry Feb, 2006 | Pubmed ID: 16354659
Altered rhythm of photoreceptor outer segment phagocytosis in beta5 integrin knockout mice.
Advances in experimental medicine and biology , 2006 | Pubmed ID: 17249564
MerTK activation during RPE phagocytosis in vivo requires alphaVbeta5 integrin.
Advances in experimental medicine and biology , 2006 | Pubmed ID: 17249615
The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2007 | Pubmed ID: 17578916
Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2007 | Pubmed ID: 17620600
Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis.
Journal of cell science Sep, 2007 | Pubmed ID: 17684062
Alphavbeta5 integrin receptors at the apical surface of the RPE: one receptor, two functions.
Advances in experimental medicine and biology , 2008 | Pubmed ID: 18188966
Lack of alphavbeta5 integrin receptor or its ligand MFG-E8: distinct effects on retinal function.
Ophthalmic research , 2008 | Pubmed ID: 18421224
The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells.
The Journal of biological chemistry Sep, 2008 | Pubmed ID: 18621729
Neural retina and MerTK-independent apical polarity of alphavbeta5 integrin receptors in the retinal pigment epithelium.
Advances in experimental medicine and biology , 2010 | Pubmed ID: 20238010
Dietary antioxidants prevent age-related retinal pigment epithelium actin damage and blindness in mice lacking αvβ5 integrin.
Free radical biology & medicine Feb, 2012 | Pubmed ID: 22178979
Expression of the integrin coreceptor transglutaminase-2 in the RPE in vivo and in culture.
Advances in experimental medicine and biology , 2012 | Pubmed ID: 22183397
αvβ5 integrin-dependent diurnal phagocytosis of shed photoreceptor outer segments by RPE cells is independent of the integrin coreceptor transglutaminase-2.
Advances in experimental medicine and biology , 2012 | Pubmed ID: 22183400
Essential diurnal Rac1 activation during retinal phagocytosis requires αvβ5 integrin but not tyrosine kinases focal adhesion kinase or Mer tyrosine kinase.
Molecular biology of the cell Mar, 2012 | Pubmed ID: 22262456
Retinal pigment epithelial cells use a MerTK-dependent mechanism to limit the phagocytic particle binding activity of αvβ5 integrin.
Biology of the cell / under the auspices of the European Cell Biology Organization Jan, 2012 | Pubmed ID: 22289110
Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina.
Proceedings of the National Academy of Sciences of the United States of America May, 2012 | Pubmed ID: 22566632
Analysis of photoreceptor rod outer segment phagocytosis by RPE cells in situ.
Methods in molecular biology (Clifton, N.J.) , 2013 | Pubmed ID: 23150373
Analysis of photoreceptor outer segment phagocytosis by RPE cells in culture.
Methods in molecular biology (Clifton, N.J.) , 2013 | Pubmed ID: 23150376
PI 3-kinase independent role for AKT in F-actin regulation during outer segment phagocytosis by RPE cells.
Experimental eye research Aug, 2013 | Pubmed ID: 23669303
Independent roles of methionine sulfoxide reductase A in mitochondrial ATP synthesis and as antioxidant in retinal pigment epithelial cells.
Free radical biology & medicine Dec, 2013 | Pubmed ID: 24120970
Lack of effect of microfilament or microtubule cytoskeleton-disrupting agents on restriction of externalized phosphatidylserine to rod photoreceptor outer segment tips.
Advances in experimental medicine and biology , 2014 | Pubmed ID: 24664685
Understanding photoreceptor outer segment phagocytosis: use and utility of RPE cells in culture.
Experimental eye research Sep, 2014 | Pubmed ID: 24780752
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