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Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection.
Journal of immunology (Baltimore, Md. : 1950) May, 2002 | Pubmed ID: 11971016
Burning up TNF toxicity for cancer therapy.
Nature medicine Jul, 2002 | Pubmed ID: 12091900
Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion.
Cancer research Dec, 2002 | Pubmed ID: 12499245
Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression.
Brain research Apr, 2003 | Pubmed ID: 12706247
Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo.
Proceedings of the National Academy of Sciences of the United States of America May, 2003 | Pubmed ID: 12746497
Defined inflammatory states in astrocyte cultures: correlation with susceptibility towards CD95-driven apoptosis.
Journal of neurochemistry Jan, 2004 | Pubmed ID: 14675162
Improvement of embryonic dopaminergic neurone survival in culture and after grafting into the striatum of hemiparkinsonian rats by CEP-1347.
Journal of neurochemistry Feb, 2004 | Pubmed ID: 14720219
Lysosomes in cell death.
Oncogene Apr, 2004 | Pubmed ID: 15077151
Asialoerythropoietin is not effective in the R6/2 line of Huntington's disease mice.
BMC neuroscience May, 2004 | Pubmed ID: 15134587
Derivatives of erythropoietin that are tissue protective but not erythropoietic.
Science (New York, N.Y.) Jul, 2004 | Pubmed ID: 15247477
Sensitization to the lysosomal cell death pathway upon immortalization and transformation.
Cancer research Aug, 2004 | Pubmed ID: 15289336
Specific modulation of astrocyte inflammation by inhibition of mixed lineage kinases with CEP-1347.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2004 | Pubmed ID: 15294995
Poly(ADP-ribose) glycohydrolase as a target for neuroprotective intervention: assessment of currently available pharmacological tools.
European journal of pharmacology Aug, 2004 | Pubmed ID: 15321729
The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin.
Journal of neurochemistry Nov, 2004 | Pubmed ID: 15525344
Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis.
The Journal of cell biology Feb, 2005 | Pubmed ID: 15716378
Inhibition of microglial inflammation by the MLK inhibitor CEP-1347.
Journal of neurochemistry Mar, 2005 | Pubmed ID: 15748162
CEP-11004, an inhibitor of the SAPK/JNK pathway, reduces TNF-alpha release from lipopolysaccharide-treated cells and mice.
European journal of pharmacology May, 2005 | Pubmed ID: 15904918
Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2005 | Pubmed ID: 16000623
The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune function.
Journal of neurochemistry Feb, 2006 | Pubmed ID: 16405499
Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia.
The European journal of neuroscience Jan, 2006 | Pubmed ID: 16420437
A role for mixed lineage kinases in granule cell apoptosis induced by cytoskeletal disruption.
Journal of neurochemistry Mar, 2006 | Pubmed ID: 16478524
Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity.
The European journal of neuroscience May, 2006 | Pubmed ID: 16817864
Reduced functional deficits, neuroinflammation, and secondary tissue damage after treatment of stroke by nonerythropoietic erythropoietin derivatives.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Mar, 2007 | Pubmed ID: 16835629
The dynamics of the LPS triggered inflammatory response of murine microglia under different culture and in vivo conditions.
Journal of neuroimmunology Nov, 2006 | Pubmed ID: 16996144
[What can a chair on alternatives to animal experimentation effectuate?].
ALTEX , 2006 | Pubmed ID: 17086353
Nonhematopoietic erythropoietin derivatives prevent motoneuron degeneration in vitro and in vivo.
Molecular medicine (Cambridge, Mass.) Jul-Aug, 2006 | Pubmed ID: 17088947
Comparison of neuroprotective effects of erythropoietin (EPO) and carbamylerythropoietin (CEPO) against ischemia-like oxygen-glucose deprivation (OGD) and NMDA excitotoxicity in mouse hippocampal slice cultures.
Experimental neurology Mar, 2007 | Pubmed ID: 17157835
Attenuated amyloid-beta aggregation and neurotoxicity owing to methionine oxidation.
Neuroreport Apr, 2007 | Pubmed ID: 17413657
Wide spectrum modulation by KP-544 in models relevant for neuronal survival.
Neuroreport Apr, 2007 | Pubmed ID: 17413659
Pathological apoptosis in the developing brain.
Apoptosis : an international journal on programmed cell death May, 2007 | Pubmed ID: 17453164
Functional and immunochemical characterisation of different antibodies against the erythropoietin receptor.
Journal of neuroscience methods Aug, 2007 | Pubmed ID: 17524492
The Sonic hedgehog pathway mediates carbamylated erythropoietin-enhanced proliferation and differentiation of adult neural progenitor cells.
The Journal of biological chemistry Nov, 2007 | Pubmed ID: 17804404
Vesicular monoamine transporter 2 regulates the sensitivity of rat dopaminergic neurons to disturbed cytosolic dopamine levels.
Brain research Dec, 2007 | Pubmed ID: 18028884
Molecular basis for detection of invading pathogens in the brain.
Journal of neuroscience research May, 2008 | Pubmed ID: 18061944
Food for thought... on the real success of 3R approaches.
ALTEX , 2008 | Pubmed ID: 18360724
High-dose erythropoietin alters platelet reactivity and bleeding time in rodents in contrast to the neuroprotective variant carbamyl-erythropoietin (CEPO).
Thrombosis and haemostasis Apr, 2008 | Pubmed ID: 18392330
Food for thought ... on the evolution of toxicology and the phasing out of animal testing.
ALTEX , 2008 | Pubmed ID: 18551232
The dawning of a new age of toxicology.
ALTEX , 2008 | Pubmed ID: 18551234
The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy.
ALTEX , 2008 | Pubmed ID: 18841314
Measurement of cellular beta-site of APP cleaving enzyme 1 activity and its modulation in neuronal assay systems.
Analytical biochemistry Apr, 2009 | Pubmed ID: 19454261
The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation.
ALTEX , 2009 | Pubmed ID: 19565166
Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells.
Toxicology and applied pharmacology Nov, 2009 | Pubmed ID: 19647008
The network formation assay: a spatially standardized neurite outgrowth analytical display for neurotoxicity screening.
Lab on a chip Mar, 2010 | Pubmed ID: 20221557
Food for thought ... on education in alternative methods in toxicology.
ALTEX , 2009 | Pubmed ID: 20383471
Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing.
ALTEX , 2010 | Pubmed ID: 20390237
The Center for Alternatives to Animal Testing - Europe (CAAT-EU): a transatlantic bridge for the paradigm shift in toxicology.
ALTEX , 2010 | Pubmed ID: 20390240
Erythropoietin: not just about erythropoiesis.
Lancet Jun, 2010 | Pubmed ID: 20609950
Reduced immunoproteasome formation and accumulation of immunoproteasomal precursors in the brains of lymphocytic choriomeningitis virus-infected mice.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2010 | Pubmed ID: 20881186
Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite.
The Journal of biological chemistry Feb, 2011 | Pubmed ID: 21081502
Food for thought ... considerations and guidelines for basic test method descriptions in toxicology.
ALTEX , 2010 | Pubmed ID: 21240472
TLR2 hypersensitivity of astrocytes as functional consequence of previous inflammatory episodes.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2011 | Pubmed ID: 21282508
Assessment of chemical-induced impairment of human neurite outgrowth by multiparametric live cell imaging in high-density cultures.
Toxicological sciences : an official journal of the Society of Toxicology May, 2011 | Pubmed ID: 21342877
Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure.
Toxicological sciences : an official journal of the Society of Toxicology Jun, 2011 | Pubmed ID: 21385734
Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line.
Journal of neurochemistry Dec, 2011 | Pubmed ID: 21434924
Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts.
Neurotoxicology Oct, 2011 | Pubmed ID: 22008243
GFAP-independent inflammatory competence and trophic functions of astrocytes generated from murine embryonic stem cells.
Glia Feb, 2012 | Pubmed ID: 22072312
Critical evaluation of the use of dogs in biomedical research and testing in Europe.
ALTEX , 2011 | Pubmed ID: 22130483
A framework program for the teaching of alternative methods (replacement, reduction, refinement) to animal experimentation.
ALTEX , 2011 | Pubmed ID: 22130484
Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry.
Chembiochem : a European journal of chemical biology Dec, 2011 | Pubmed ID: 22162214
Highlight report: towards the replacement of in vivo repeated dose systemic toxicity testing.
Archives of toxicology Jan, 2012 | Pubmed ID: 22187068
Uncoupling of ATP-depletion and cell death in human dopaminergic neurons.
Neurotoxicology Aug, 2012 | Pubmed ID: 22206971
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.
ALTEX , 2012 | Pubmed ID: 22307314
Locally resolved membrane binding affinity of the N-terminus of α-synuclein.
Biochemistry May, 2012 | Pubmed ID: 22494024
Control of Aβ release from human neurons by differentiation status and RET signaling.
Neurobiology of aging Jan, 2013 | Pubmed ID: 22534065
Evaluation of developmental toxicants and signaling pathways in a functional test based on the migration of human neural crest cells.
Environmental health perspectives Aug, 2012 | Pubmed ID: 22571897
Autocatalytic nitration of prostaglandin endoperoxide synthase-2 by nitrite inhibits prostanoid formation in rat alveolar macrophages.
Antioxidants & redox signaling Nov, 2012 | Pubmed ID: 22578329
Extensive transcriptional regulation of chromatin modifiers during human neurodevelopment.
PloS one , 2012 | Pubmed ID: 22590590
Compound selection for in vitro modeling of developmental neurotoxicity.
Frontiers in bioscience (Landmark edition) , 2012 | Pubmed ID: 22652791
Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome.
Human molecular genetics Sep, 2012 | Pubmed ID: 22723015
Characterization of mouse cell line IMA 2.1 as a potential model system to study astrocyte functions.
ALTEX , 2012 | Pubmed ID: 22847254
Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics, and drugs with animal-free methods.
ALTEX , 2012 | Pubmed ID: 23138508
The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans.
ALTEX , 2012 | Pubmed ID: 23138511
Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach.
Archives of toxicology Jan, 2013 | Pubmed ID: 23179753
A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles.
Archives of toxicology Apr, 2013 | Pubmed ID: 23203475
Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.
Journal of neurochemistry May, 2013 | Pubmed ID: 23452040
Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice.
Archives of toxicology Apr, 2013 | Pubmed ID: 23503654
Metabolomics in toxicology and preclinical research.
ALTEX , 2013 | Pubmed ID: 23665807
Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice.
ALTEX , 2013 | Pubmed ID: 23665808
Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants.
Archives of toxicology Dec, 2013 | Pubmed ID: 23670202
Monocrotophos in Gandaman village: India school lunch deaths and need for improved toxicity testing.
Archives of toxicology Oct, 2013 | Pubmed ID: 23943209
Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases.
ALTEX , 2013 | Pubmed ID: 24173167
A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems.
ALTEX , 2013 | Pubmed ID: 24173170
Test systems of developmental toxicity: state-of-the art and future perspectives.
Archives of toxicology Dec, 2013 | Pubmed ID: 24190503
Targeting chelatable iron as a therapeutic modality in Parkinson's disease.
Antioxidants & redox signaling Jul, 2014 | Pubmed ID: 24251381
Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells.
Chemical research in toxicology Mar, 2014 | Pubmed ID: 24383497
Epigenetics and transcriptomics to detect adverse drug effects in model systems of human development.
Basic & clinical pharmacology & toxicology Jul, 2014 | Pubmed ID: 24476462
Instruments for assessing risk of bias and other methodological criteria of animal studies: omission of well-established methods.
Environmental health perspectives Mar, 2014 | Pubmed ID: 24583401
Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities.
ALTEX , 2014 | Pubmed ID: 24687333
Acrylamide alters neurotransmitter induced calcium responses in murine ESC-derived and primary neurons.
Neurotoxicology Jul, 2014 | Pubmed ID: 24726791
Identification and affinity-quantification of ß-amyloid and α-synuclein polypeptides using on-line SAW-biosensor-mass spectrometry.
Journal of the American Society for Mass Spectrometry Aug, 2014 | Pubmed ID: 24845351
From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects.
Archives of toxicology Jul, 2014 | Pubmed ID: 24935251
Current approaches and future role of high content imaging in safety sciences and drug discovery.
ALTEX , 2014 | Pubmed ID: 25027442
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology.
ALTEX , 2014 | Pubmed ID: 25027500
Lineage-specific regulation of epigenetic modifier genes in human liver and brain.
PloS one , 2014 | Pubmed ID: 25054330
Consensus report on the future of animal-free systemic toxicity testing.
ALTEX , 2014 | Pubmed ID: 25061899
Impairment of glutamate signaling in mouse central nervous system neurons in vitro by tri-ortho-cresyl phosphate at noncytotoxic concentrations.
Toxicological sciences : an official journal of the Society of Toxicology Nov, 2014 | Pubmed ID: 25199799
Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis.
Nature communications , 2014 | Pubmed ID: 25208761
Alpha-synuclein binds to the inner membrane of mitochondria in an α-helical conformation.
Chembiochem : a European journal of chemical biology Nov, 2014 | Pubmed ID: 25209675
Toxicogenomics directory of chemically exposed human hepatocytes.
Archives of toxicology Dec, 2014 | Pubmed ID: 25399406
International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes.
Archives of toxicology Feb, 2015 | Pubmed ID: 25618548
Systems Toxicology: The Future of Risk Assessment.
International journal of toxicology Mar, 2015 | Pubmed ID: 25804424
From smoking guns to footprints: mining for critical events of toxicity pathways in transcriptome data.
Archives of toxicology May, 2015 | Pubmed ID: 25851820
Prevention of human dopaminergic neurodegeneration in an astrocytes co-culture system allowing endogenous drug metabolism.
British journal of pharmacology May, 2015 | Pubmed ID: 25989025
Vaibhav Shinde*,1,
Stefanie Klima*,2,
Perumal Srinivasan Sureshkumar1,
Kesavan Meganathan1,
Smita Jagtap1,
Eugen Rempel3,
Jörg Rahnenführer3,
Jan Georg Hengstler4,
Tanja Waldmann2,
Jürgen Hescheler1,
Marcel Leist*,2,
Agapios Sachinidis*,1
1Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne,
2Department of Biology, University of Konstanz,
3Department of Statistics, Technical University of Dortmund,
4Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund
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