Ronald B. Tjalkens

Manganese potentiates lipopolysaccharide-induced expression of NOS2 in C6 glioma cells through mitochondrial-dependent activation of nuclear factor kappaB.

CI-1010 induced opening of the mitochondrial permeability transition pore precedes oxidative stress and apoptosis in SY5Y neuroblastoma cells.

Prenatal expression of N-acetyltransferases in C57Bl/6 mice.

Regional variation in the activation threshold for 1,3-DNB-induced mitochondrial permeability transition in brainstem and cortical astrocytes.

The effects of genetic variation in N-acetyltransferases on 4-aminobiphenyl genotoxicity in mouse liver.

The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes.

NF-kappaB-dependent production of nitric oxide by astrocytes mediates apoptosis in differentiated PC12 neurons following exposure to manganese and cytokines.

Modulation of intercellular calcium signaling by melatonin in avian and mammalian astrocytes is brain region-specific.

Manganese-induced neurotoxicity: the role of astroglial-derived nitric oxide in striatal interneuron degeneration.

Manganese suppresses ATP-dependent intercellular calcium waves in astrocyte networks through alteration of mitochondrial and endoplasmic reticulum calcium dynamics.

The peroxisome proliferator-activated receptor-gamma agonist 1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells.

Manganese potentiates nuclear factor-kappaB-dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways.

Nuclear factor kappa-B mediates selective induction of neuronal nitric oxide synthase in astrocytes during low-level inflammatory stimulation with MPTP.

Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis.

Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes.

Age-dependent susceptibility to manganese-induced neurological dysfunction.

Developmental exposure to manganese increases adult susceptibility to inflammatory activation of glia and neuronal protein nitration.

Toxicological and pathophysiological roles of reactive oxygen and nitrogen species.

Low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine causes inflammatory activation of astrocytes in nuclear factor-κB reporter mice prior to loss of dopaminergic neurons.

Manganese-induced NF-kappaB activation and nitrosative stress is decreased by estrogen in juvenile mice.

1,3-Dinitrobenzene-induced metabolic impairment through selective inactivation of the pyruvate dehydrogenase complex.

Detection of nitric oxide formation in primary neural cells and tissues.

Role of oxidative stress and the mitochondrial permeability transition in methylmercury cytotoxicity.

Gene deletion of nos2 protects against manganese-induced neurological dysfunction in juvenile mice.

Manganese inhibits ATP-induced calcium entry through the transient receptor potential channel TRPC3 in astrocytes.

Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease.

The atrazine metabolite diaminochlorotriazine suppresses LH release from murine LβT2 cells by suppressing GnRH-induced intracellular calcium transients.

Repeated exposure to low doses of kainic acid activates nuclear factor kappa B (NF-κB) prior to seizure in transgenic NF-κB/EGFP reporter mice.

Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells.

Domoic acid-induced seizures in California sea lions (Zalophus californianus) are associated with neuroinflammatory brain injury.

Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease.

The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB.

Nuclear receptor 4A (NR4A) family - orphans no more.

Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response element-binding protein.