Dirk Elewaut

Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice.

Insulin-like growth factor 1-induced interleukin-1 receptor II overrides the activity of interleukin-1 and controls the homeostasis of the extracellular matrix of cartilage.

NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells.

The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells.

Mapping of the leptin binding sites and design of a leptin antagonist.

Analysis of chondrocyte functional markers and pericellular matrix components by flow cytometry.

Lymphotoxin alpha 1 beta 2: a critical mediator in V alpha 14i NKT cell differentiation.

Natural killer T cells and rheumatoid arthritis: friend or foe?

Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-beta receptor expression.

Chronically inflamed synovium from spondyloarthropathy and rheumatoid arthritis investigated by protein expression profiling followed by tandem mass spectrometry.

A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection.

Formatted anti-tumor necrosis factor alpha VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritis.

A unique lymphotoxin {alpha}beta-dependent pathway regulates thymic emigration of V{alpha}14 invariant natural killer T cells.

Diagnostic value of anti-human citrullinated fibrinogen ELISA and comparison with four other anti-citrullinated protein assays.

The unconventional role of LT alpha beta in T cell differentiation.

Osteochondral repair in synovial joints.

The intimate relationship between gut and joint in spondyloarthropathies.

A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner.

Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases.

A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis.

Invariant NKT cells promote CD8+ cytotoxic T cell responses by inducing CD70 expression on dendritic cells.

Synthesis and in vitro evaluation of alpha-GalCer epimers.

Spondyloarthropathies: progress and challenges.

Adalimumab with or without methotrexate in juvenile rheumatoid arthritis.

Synthesis and in vivo evaluation of 4-deoxy-4,4-difluoro-KRN7000.

Clinical observations programme in SpA: disease parameters, treatment options and practical management issues.

Differential expression of alphaB-crystallin and evidence of its role as a mediator of matrix gene expression in osteoarthritis.

The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000.

Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis.

Thymic emigration: sphingosine-1-phosphate receptor-1-dependent models and beyond.

LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen.

6'-derivatised alpha-GalCer analogues capable of inducing strong CD1d-mediated Th1-biased NKT cell responses in mice.

Treatment of ankylosing spondylitis and extra-articular manifestations in everyday rheumatology practice.

Application of a new anti-zearalenone monoclonal antibody in different immunoassay formats.

Progress in spondylarthritis. Immunopathogenesis of spondyloarthritis: which cells drive disease?

Cutting edge: the chemokine receptor CXCR3 retains invariant NK T cells in the thymus.

Dendritic cells from spondylarthritis-prone HLA-B27-transgenic rats display altered cytoskeletal dynamics, class II major histocompatibility complex expression, and viability.

Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice.

Differential mechanism of NF-kappaB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts.

Morbid anatomy of 'erosive osteoarthritis' of the interphalangeal finger joints: an optimised scoring system to monitor disease progression in affected joints.

Invariant natural killer T cells in rheumatic disease: a joint dilemma.

Invariant natural killer T cells are natural regulators of murine spondylarthritis.

Interactions between gut inflammation and arthritis/spondylitis.

Targeting inflammation using selective glucocorticoid receptor modulators.

Synthesis and evaluation of amino-modified alpha-GalCer analogues.

Polymorphic variants of LIGHT (TNF superfamily-14) alter receptor avidity and bioavailability.

Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins.

A multiparameter approach to monitor disease activity in collagen-induced arthritis.

Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD.

Novel autoantibody markers for early and seronegative rheumatoid arthritis.

Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.

In pursuit of B-cell synovial autoantigens in rheumatoid arthritis: Confirmation of citrullinated fibrinogen, detection of vimentin, and introducing carbonic anhydrase as a possible new synovial autoantigen.

Proteomics in rheumatology: The beginning of a fairy tale?

Differential mucosal expression of Th17-related genes between the inflamed colon and ileum of patients with inflammatory bowel disease.

Linking Crohn's disease and ankylosing spondylitis: it's all about genes!

Mechanisms regulating TNF-driven gut and joint inflammation.

An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation.

Disruption of the SapM locus in Mycobacterium bovis BCG improves its protective efficacy as a vaccine against M. tuberculosis.

Specific anti-nuclear antibodies in systemic sclerosis patients with and without skin involvement: an extended methodological approach.

Optimized alkylated cyclodextrin polysulphates with reduced risks on thromboembolic accidents improve osteoarthritic chondrocyte metabolism.

Histopathological cutaneous alterations in systemic sclerosis: a clinicopathological study.

Systematic candidate gene investigations in the SPA2 locus (9q32) show an association between TNFSF8 and susceptibility to spondylarthritis.

Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis.

Reliability and validity of the INFOOT three-dimensional foot digitizer for patients with rheumatoid arthritis.

The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity.

Mucosal inflammation in spondylarthritides: past, present, and future.

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis.

Selection of non-competitive leptin antagonists using a random nanobody-based approach.

Regulating the regulators: SOCS3 joins the dance.

Midterm results of the treatment of cartilage defects in the knee using alginate beads containing human mature allogenic chondrocytes.

Safe and well tolerated.

A pilot study of the use of an osteochondral scaffold plug for cartilage repair in the knee and how to deal with early clinical failures.

A clinically applicable six-segmented foot model.

Involvement of endoplasmic reticulum stress in inflammatory bowel disease: a different implication for colonic and ileal disease?

Divergent synthetic approach to 6''-modified α-GalCer analogues.

Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification.

Motion for debate: the development of ankylosis in ankylosing spondylitis is largely dependent on inflammation.

Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice.

The transition of acute to chronic bowel inflammation in spondyloarthritis.

Activated iNKT cells promote memory CD8+ T cell differentiation during viral infection.

Natural killer T cells: born in the thymus, raised in the gut.

Quantitative assessment of foot structure in rheumatoid arthritis by a foot digitizer: detection of deformities even in the absence of erosions.

Quantification of IFNγ- and IL17-producing cells after stimulation with citrullinated proteins in healthy subjects and RA patients.

Natural killer T cells in adipose tissue prevent insulin resistance.

Tumor necrosis factor α-induced proteins: natural brakes on inflammation.

Investigating the genetic association between ERAP1 and spondyloarthritis.

Quantification of citrullination by means of skewed isotope distribution pattern.

Pathophysiology and role of the gastrointestinal system in spondyloarthritides.

Therapy for spondyloarthritis: the role of extra-articular manifestations (eye, skin).

Two-year results of an open pilot study of a 2-treatment course with rituximab in patients with early systemic sclerosis with diffuse skin involvement.

Synthesis of 6"-triazole-substituted α-GalCer analogues as potent iNKT cell stimulating ligands.

Microscopic gut inflammation in axial spondyloarthritis: a multiparametric predictive model.

Spondyloarthritis: A conundrum: classifying patients with SpA in daily practice.

Should we be morbid about comorbidities in the rheumatic diseases?

Entering the era of proteomics in rheumatology.

Senescence marker killer cell lectin-like receptor G1 (KLRG1) contributes to TNF-α production by interaction with its soluble E-cadherin ligand in chronically inflamed joints.

Preclinical evaluation of invariant natural killer T cells in the 5T33 multiple myeloma model.

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci.

Treating spondyloarthritis, including ankylosing spondylitis and psoriatic arthritis, to target: recommendations of an international task force.

Microbes, the gut and ankylosing spondylitis.

How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy.

Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative.

Bacterial CD1d-restricted glycolipids induce IL-10 production by human regulatory T cells upon cross-talk with invariant NKT cells.

Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells.

Heat-shock proteins in stromal joint tissues: innocent bystanders or disease-initiating proteins?

Enhanced TCR footprint by a novel glycolipid increases NKT-dependent tumor protection.

A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis.

Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex: results from the GIANT cohort.

Spondyloarthritis: Gut inflammation in SpA: flagellin joins the dance?

An in silico approach for modelling T-helper polarizing iNKT cell agonists.

Growth differentiation factor 15, a marker of lung involvement in systemic sclerosis, is involved in fibrosis development but is not indispensable for fibrosis development.

Relevance of the gut/joint axis for the management of spondyloarthritis in daily clinical practice.

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis.

Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level.

Etanercept versus monoclonal antibodies in axial spondyloarthritis: game over?

Distinct dysregulation of the small leucine-rich repeat protein family in osteoarthritic acetabular labrum compared to articular cartilage.

The thymic microenvironment differentially regulates development and trafficking of invariant NKT cell sublineages.

Referral patterns, diagnosis, and disease management of patients with axial spondyloarthritis: results of an international survey.

The role of the gut and microbes in the pathogenesis of spondyloarthritis.

Integrating the pathogenesis of spondyloarthritis: gut and joint united?

Commensal microbiota influence systemic autoimmune responses.

IL-23 responsive innate-like T cells in spondyloarthritis: the less frequent they are, the more vital they appear.

ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients.

Heterogeneity of synovial molecular patterns in patients with arthritis.

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.

Synthesis of C-5″ and C-6″-modified α-GalCer analogues as iNKT-cell agonists.

Spreading spondyloarthritis: are ILCs cytokine shuttles from base camp gut?