Department of Cancer Immunology and AIDS
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Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors.
Retrovirology , 2009 | Pubmed ID: 19265512
HIV-1 integrase inhibitors: 2007-2008 update.
Medicinal research reviews Nov, 2010 | Pubmed ID: 20135632
A Symmetric Region of the HIV-1 Integrase Dimerization Interface Is Essential for Viral Replication.
PloS one , 2012 | Pubmed ID: 23028829
Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.
Journal of medicinal chemistry Mar, 2013 | Pubmed ID: 23445471
Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction.
Bioorganic & medicinal chemistry Oct, 2013 | Pubmed ID: 23985689
Biochemical characterization of novel retroviral integrase proteins.
PloS one , 2013 | Pubmed ID: 24124581
Alteration of select gene expression patterns in individuals infected with HIV-1.
Journal of medical virology Apr, 2014 | Pubmed ID: 24482297
Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding.
Nucleic acids research Apr, 2014 | Pubmed ID: 24520116
Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75.
Bioorganic & medicinal chemistry Jun, 2014 | Pubmed ID: 24794743
Molecular mechanisms of retroviral integration site selection.
Nucleic acids research , 2014 | Pubmed ID: 25147212
Host and viral determinants for MxB restriction of HIV-1 infection.
Retrovirology , 2014 | Pubmed ID: 25348155
Key determinants of target DNA recognition by retroviral intasomes.
Retrovirology , 2015 | Pubmed ID: 25924943
Structural basis for retroviral integration into nucleosomes.
Nature Jul, 2015 | Pubmed ID: 26061770
Sites of retroviral DNA integration: From basic research to clinical applications.
Critical reviews in biochemistry and molecular biology Jan-Feb, 2016 | Pubmed ID: 26508664
A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2016 | Pubmed ID: 26858452
The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.
ACS chemical biology Mar, 2016 | Pubmed ID: 26910179
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