Department of Developmental and Regenerative Biology,
Black Family Stem Cell Institute,
Department of Pharmacology and Systems Therapeutics
Ihor R. Lemischka has not added Biography.
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Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells.
Stem cells (Dayton, Ohio) Jun, 2011 | Pubmed ID: 21563278
Cells for repair: breakout session summary.
Annals of the New York Academy of Sciences Jun, 2002 | Pubmed ID: 12081862
A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover.
Blood Sep, 2002 | Pubmed ID: 12200366
A molecular profile of a hematopoietic stem cell niche.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2002 | Pubmed ID: 12226475
A stem cell molecular signature.
Science (New York, N.Y.) Oct, 2002 | Pubmed ID: 12228721
Stem cells: interactive niches.
Nature Oct, 2003 | Pubmed ID: 14574394
"Tie-ing" down the hematopoietic niche.
Cell Jul, 2004 | Pubmed ID: 15260982
Stem cell biology: a view toward the future.
Annals of the New York Academy of Sciences Jun, 2005 | Pubmed ID: 15958706
Diversification of stem cell molecular repertoire by alternative splicing.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2005 | Pubmed ID: 16183747
Alternative splicing increases complexity of stem cell transcriptome.
Cell cycle (Georgetown, Tex.) Feb, 2006 | Pubmed ID: 16479168
Stem cells and their niches.
Science (New York, N.Y.) Mar, 2006 | Pubmed ID: 16574858
Genomewide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America May, 2006 | Pubmed ID: 16621925
Delivery of short hairpin RNAs--triggers of gene silencing--into mouse embryonic stem cells.
Nature methods May, 2006 | Pubmed ID: 16628211
The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells.
Nature neuroscience Jun, 2006 | Pubmed ID: 16680166
Dissecting self-renewal in stem cells with RNA interference.
Nature Aug, 2006 | Pubmed ID: 16767105
shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development.
Cell stem cell Jun, 2007 | Pubmed ID: 18371338
A genomewide functional network for the laboratory mouse.
PLoS computational biology , 2008 | Pubmed ID: 18818725
Alternative induced pluripotent stem cell characterization criteria for in vitro applications.
Cell stem cell Mar, 2009 | Pubmed ID: 19265656
Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain.
Genes & development Mar, 2009 | Pubmed ID: 19270157
Systems biology of stem cell fate and cellular reprogramming.
Nature reviews. Molecular cell biology Oct, 2009 | Pubmed ID: 19738627
Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cells.
Stem cells (Dayton, Ohio) Dec, 2009 | Pubmed ID: 19785031
Delayed differentiation in embryonic stem cells and mesodermal progenitors in the absence of CtBP2.
Mechanisms of development Jan-Feb, 2010 | Pubmed ID: 19825414
GATE: software for the analysis and visualization of high-dimensional time series expression data.
Bioinformatics (Oxford, England) Jan, 2010 | Pubmed ID: 19892805
Systems-level dynamic analyses of fate change in murine embryonic stem cells.
Nature Nov, 2009 | Pubmed ID: 19924215
Hooking up with Oct4.
Cell stem cell Apr, 2010 | Pubmed ID: 20362529
Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome.
Nature Jun, 2010 | Pubmed ID: 20535210
Exploration of self-renewal and pluripotency in ES cells using RNAi.
Methods in enzymology , 2010 | Pubmed ID: 20699150
Toward a complete in silico, multi-layered embryonic stem cell regulatory network.
Wiley interdisciplinary reviews. Systems biology and medicine Nov-Dec, 2010 | Pubmed ID: 20890967
SVM classifier to predict genes important for self-renewal and pluripotency of mouse embryonic stem cells.
BMC systems biology Dec, 2010 | Pubmed ID: 21176149
Mapping dynamic histone acetylation patterns to gene expression in nanog-depleted murine embryonic stem cells.
PLoS computational biology Dec, 2010 | Pubmed ID: 21187909
Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2011 | Pubmed ID: 21252303
Prdm16 is a physiologic regulator of hematopoietic stem cells.
Blood May, 2011 | Pubmed ID: 21343612
Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells.
Nature biotechnology Mar, 2011 | Pubmed ID: 21358635
Induced pluripotent stem cell-derived cardiomyocytes as models for genetic cardiovascular disorders.
Current opinion in cardiology May, 2011 | Pubmed ID: 21451408
Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network.
Cell Apr, 2011 | Pubmed ID: 21477851
Stem cells and reprogramming: breaking the epigenetic barrier?
Trends in pharmacological sciences Jul, 2011 | Pubmed ID: 21621281
Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells.
Blood Sep, 2011 | Pubmed ID: 21652676
KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.
Cancer cell Jan, 2012 | Pubmed ID: 22264792
Combining competition assays with genetic complementation strategies to dissect mouse embryonic stem cell self-renewal and pluripotency.
Nature protocols Mar, 2012 | Pubmed ID: 22441292
Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling.
Cell stem cell Aug, 2012 | Pubmed ID: 22862944
Reprogramming cell fates: insights from combinatorial approaches.
Annals of the New York Academy of Sciences Aug, 2012 | Pubmed ID: 22901251
Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2012 | Pubmed ID: 22988117
Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity.
Nature cell biology Nov, 2012 | Pubmed ID: 23103910
SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal.
Epigenetics Feb, 2013 | Pubmed ID: 23324626
Induction of a hemogenic program in mouse fibroblasts.
Cell stem cell Aug, 2013 | Pubmed ID: 23770078
ESCAPE: database for integrating high-content published data collected from human and mouse embryonic stem cells.
Database : the journal of biological databases and curation , 2013 | Pubmed ID: 23794736
Patterning pluripotency in embryonic stem cells.
Stem cells (Dayton, Ohio) Sep, 2013 | Pubmed ID: 23843329
Statistical mechanics of pluripotency.
Cell Aug, 2013 | Pubmed ID: 23911316
Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm.
Stem cells (Dayton, Ohio) Jan, 2014 | Pubmed ID: 24022884
Epigenetic roles of MLL oncoproteins are dependent on NF-κB.
Cancer cell Oct, 2013 | Pubmed ID: 24054986
"There will be blood" from fibroblasts.
Cell cycle (Georgetown, Tex.) , 2014 | Pubmed ID: 24335410
'From blood to blood': de-differentiation of hematopoietic progenitors to stem cells.
The EMBO journal Jul, 2014 | Pubmed ID: 24907133
Genomic editing tools to model human diseases with isogenic pluripotent stem cells.
Stem cells and development Nov, 2014 | Pubmed ID: 25075441
Construction and validation of a regulatory network for pluripotency and self-renewal of mouse embryonic stem cells.
PLoS computational biology Aug, 2014 | Pubmed ID: 25122140
A genome-wide RNAi screen identifies opposing functions of Snai1 and Snai2 on the Nanog dependency in reprogramming.
Molecular cell Oct, 2014 | Pubmed ID: 25240402
NetExplore: a web server for modeling small network motifs.
Bioinformatics (Oxford, England) Jun, 2015 | Pubmed ID: 25637559
Modeling familial cancer with induced pluripotent stem cells.
Cell Apr, 2015 | Pubmed ID: 25860607
Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming.
Cell stem cell Jun, 2015 | Pubmed ID: 25936917
Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm.
Stem cell reports Jul, 2015 | Pubmed ID: 26095607
Distribution Analyzer, a methodology for identifying and clustering outlier conditions from single-cell distributions, and its application to a Nanog reporter RNAi screen.
BMC bioinformatics Jul, 2015 | Pubmed ID: 26198214
Single-Cell Analyses of ESCs Reveal Alternative Pluripotent Cell States and Molecular Mechanisms that Control Self-Renewal.
Stem cell reports Aug, 2015 | Pubmed ID: 26267829
Myeloid Dysregulation in a Human Induced Pluripotent Stem Cell Model of PTPN11-Associated Juvenile Myelomonocytic Leukemia.
Cell reports Oct, 2015 | Pubmed ID: 26456833
Making a Hematopoietic Stem Cell.
Trends in cell biology Mar, 2016 | Pubmed ID: 26526106
Converting cell fates: generating hematopoietic stem cells de novo via transcription factor reprogramming.
Annals of the New York Academy of Sciences Apr, 2016 | Pubmed ID: 26748878
Hematopoietic Reprogramming In Vitro Informs In Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells.
Developmental cell Mar, 2016 | Pubmed ID: 26954547
Emerging Modeling Concepts and Solutions in Stem Cell Research.
Current topics in developmental biology , 2016 | Pubmed ID: 26970649
A dual molecular analogue tuner for dissecting protein function in mammalian cells.
Nature communications May, 2016 | Pubmed ID: 27230261
Modeling Cancer with Pluripotent Stem Cells.
Trends in cancer Sep, 2016 | Pubmed ID: 27722205
Michael G. Daniel1,2,3,
Carlos-Filipe Pereira4,
Jeffrey M. Bernitz1,2,3,
Ihor R. Lemischka1,3,5,
Kateri Moore1,3
1Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai,
2The Graduate School of Biomedical Science, Icahn School of Medicine at Mount Sinai,
3Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai,
4Center for Neuroscience and Cell Biology, University of Coimbra,
5Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai
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