Christopher R. Parish

Cancer immunotherapy: the past, the present and the future.

Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88: phosphomannopentaose sulfate directly binds FGF-2, blocks cellular signaling, and inhibits proliferation.

Convergent synthesis and preliminary biological evaluations of the stilbenolignan (+/-)-aiphanol and various congeners.

Phosphomannopentaose sulfate (PI-88): heparan sulfate mimetic with clinical potential in multiple vascular pathologies.

Histidine-rich glycoprotein binds to cell-surface heparan sulfate via its N-terminal domain following Zn2+ chelation.

The low molecular weight heparan sulfate-mimetic, PI-88, inhibits cell-to-cell spread of herpes simplex virus.

Targeting dendritic cells with antigen-containing liposomes: a highly effective procedure for induction of antitumor immunity and for tumor immunotherapy.

Plasminogen is tethered with high affinity to the cell surface by the plasma protein, histidine-rich glycoprotein.

Targeting dendritic cells with antigen-containing liposomes: antitumour immunity.

A synthetic heparanase inhibitor reduces proteinuria in passive Heymann nephritis.

Use of sulfated linked cyclitols as heparan sulfate mimetics to probe the heparin/heparan sulfate binding specificity of proteins.

Histidine-rich glycoprotein: A novel adaptor protein in plasma that modulates the immune, vascular and coagulation systems.

A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancer.

Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan.

Histidine-rich glycoprotein specifically binds to necrotic cells via its amino-terminal domain and facilitates necrotic cell phagocytosis.

Heparan sulfate and inflammation.

C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties.

Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides.

The role of heparan sulphate in inflammation.

Liposomal vaccines--targeting the delivery of antigen.

Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance.

Eotaxin selectively binds heparin. An interaction that protects eotaxin from proteolysis and potentiates chemotactic activity in vivo.

Monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl ester.

Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer.

Use of the intracellular fluorescent dye CFSE to monitor lymphocyte migration and proliferation.

Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritis.

Dynamic histone variant exchange accompanies gene induction in T cells.

Use of the intracellular fluorescent dye CFSE to monitor lymphocyte migration and proliferation.

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo.

Targeted liposomal delivery of TLR9 ligands activates spontaneous antitumor immunity in an autochthonous cancer model.

The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment.

T cell receptor sharing by cytotoxic T lymphocytes facilitates efficient virus control.

Regulation of histidine-rich glycoprotein (HRG) function via plasmin-mediated proteolytic cleavage.

Immunology and Cell Biology Publication of the Year Award 2008.

Interplay between chromatin remodeling and epigenetic changes during lineage-specific commitment to granzyme B expression.

Activation of cathepsin D by glycosaminoglycans.

Histidine-rich glycoprotein is a novel plasma pattern recognition molecule that recruits IgG to facilitate necrotic cell clearance via FcgammaRI on phagocytes.

A novel fluorescent-based assay reveals that thrombopoietin signaling and Bcl-X(L) influence, respectively, platelet and erythrocyte lifespans.

Heparanase in primary human osteoblasts.

Alternatively activated macrophage possess antitumor cytotoxicity that is induced by IL-4 and mediated by arginase-1.

Histidine-rich glycoprotein binds heparanase and regulates its enzymatic activity and cell surface interactions.

Drug-induced thrombocytopenia: development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG.

Histidine-rich glycoprotein functions cooperatively with cell surface heparan sulfate on phagocytes to promote necrotic cell uptake.

Immunology and cell biology publication of the year award 2009.

Histidine-rich glycoprotein: the Swiss Army knife of mammalian plasma.

The yeast homolog of heme oxygenase-1 affords cellular antioxidant protection via the transcriptional regulation of known antioxidant genes.

A one-pot synthesis and biological activity of ageladine A and analogues.

Chromatin-associated protein kinase C-θ regulates an inducible gene expression program and microRNAs in human T lymphocytes.

Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine.

Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-D-glucuronidase (heparanase).

Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes.

Yin Yang-1 inhibits tumor cell growth and inhibits p21WAF1/Cip1 complex formation with cdk4 and cyclin D1.

New and improved methods for measuring lymphocyte proliferation in vitro and in vivo using CFSE-like fluorescent dyes.

DNAzyme targeting c-jun suppresses skin cancer growth.

Fluorescent target array killing assay: a multiplex cytotoxic T-cell assay to measure detailed T-cell antigen specificity and avidity in vivo.

The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes.

Upregulation of heparanase in high-glucose-treated endothelial cells promotes endothelial cell migration and proliferation and correlates with Akt and extracellular-signal-regulated kinase phosphorylation.

Destroying c-jun Messenger: new insights into biological mechanisms of DNAzyme function.

Reduced retinal microvascular density, improved forepaw reach, comparative microarray and gene set enrichment analysis with c-jun targeting DNA enzyme.

Platelets and P-selectin control tumor cell metastasis in an organ-specific manner and independently of NK cells.

Heparanase and vascular endothelial growth factor expression is increased in hypoxia-induced retinal neovascularization.

Fluorescent target array T helper assay: a multiplex flow cytometry assay to measure antigen-specific CD4+ T cell-mediated B cell help in vivo.

The accumulation of circulating histones on heparan sulphate in the capillary glycocalyx of the lungs.

The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil.

Comment on: Korpos et al. The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human. Diabetes 2013;62:531-542.

New insights into intracellular locations and functions of heme oxygenase-1.

Heparan sulfate: a ubiquitous glycosaminoglycan with multiple roles in immunity.

Heparanase and Autoimmune Diabetes.

Mice Deficient in the Putative Phospholipid Flippase ATP11C Exhibit Altered Erythrocyte Shape, Anemia and Reduced Erythrocyte Lifespan.