Leonid Margolis

Preferential coreceptor utilization and cytopathicity by dual-tropic HIV-1 in human lymphoid tissue ex vivo.

Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue.

Human immunodeficiency virus type 1 induces apoptosis in CD4(+) but not in CD8(+) T cells in ex vivo-infected human lymphoid tissue.

CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo.

Human immunodeficiency virus type 1 (HIV-1) non-B subtypes are similar to HIV-1 subtype B in that coreceptor specificity is a determinant of cytopathicity in human lymphoid tissue infected ex vivo.

Segregation of R5 and X4 HIV-1 variants to memory T cell subsets differentially expressing CD62L in ex vivo infected human lymphoid tissue.

Cytokines--strategic weapons in germ warfare?

Bystander CD4+ T lymphocytes survive in HIV-infected human lymphoid tissue.

Real-time PCR assay of individual human immunodeficiency virus type 1 variants in coinfected human lymphoid tissues.

Multilineage differentiation of rhesus monkey embryonic stem cells in three-dimensional culture systems.

Isolation and clonal analysis of human epidermal keratinocyte stem cells in long-term culture.

Pathogenic effects of human herpesvirus 6 in human lymphoid tissue ex vivo.

Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin.

CXCR4-tropic HIV-1 suppresses replication of CCR5-tropic HIV-1 in human lymphoid tissue by selective induction of CC-chemokines.

Noninfectious X4 but not R5 human immunodeficiency virus type 1 virions inhibit humoral immune responses in human lymphoid tissue ex vivo.

A naturally occurring variation in the proline-rich region does not attenuate human immunodeficiency virus type 1 nef function.

Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue.

Depletion of CD4 T lymphocytes in human lymphoid tissue infected ex vivo with doxycycline-dependent HIV-1.

Vpr and Vpu are important for efficient human immunodeficiency virus type 1 replication and CD4+ T-cell depletion in human lymphoid tissue ex vivo.

Complex extracellular matrices promote tissue-specific stem cell differentiation.

Invasion of human tissue ex vivo by Borrelia burgdorferi.

Inhibition of HIV-1 replication in human lymphoid tissues ex vivo by measles virus.

Pertussis toxin B-oligomer dissociates T cell activation and HIV replication in CD4 T cells released from infected lymphoid tissue.

Differential pathogenesis of primary CCR5-using human immunodeficiency virus type 1 isolates in ex vivo human lymphoid tissue.

The nonnucleoside reverse transcriptase inhibitor UC-781 inhibits human immunodeficiency virus type 1 infection of human cervical tissue and dissemination by migratory cells.

Selective transmission of CCR5-utilizing HIV-1: the 'gatekeeper' problem resolved?

Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicides.

Differentiation of rhesus monkey embryonic stem cells in three-dimensional collagen matrix.

Viral interactions in human lymphoid tissue: Human herpesvirus 7 suppresses the replication of CCR5-tropic human immunodeficiency virus type 1 via CD4 modulation.

Evolution of CXCR4-using human immunodeficiency virus type 1 SF162 is associated with two unique envelope mutations.

Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.

Cell-cell and cell-extracellular matrix interactions regulate embryonic stem cell differentiation.

HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1.

Design and cellular kinetics of dansyl-labeled CADA derivatives with anti-HIV and CD4 receptor down-modulating activity.

Measles virus vaccine attenuation: suboptimal infection of lymphatic tissue and tropism alteration.

Sustained secretion of immunoglobulin by long-lived human tonsil plasma cells.

HIV-1 induced activation of CD4+ T cells creates new targets for HIV-1 infection in human lymphoid tissue ex vivo.

Semen-derived amyloid fibrils drastically enhance HIV infection.

Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo.

Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study.

The lymph node in HIV pathogenesis.

Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues.

A highly sensitive and dynamic immunofluorescent cytometric bead assay for the detection of HIV-1 p24.

Unsung hero Robert C. Gallo.

Coinfecting viruses as determinants of HIV disease.

Integrating integrins into HIV pathogenesis.

Use of human tissue explants to study human infectious agents.

Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man.

Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase.

Measurement of human immunodeficiency virus type 1 preintegration transcription by using Rev-dependent Rev-CEM cells reveals a sizable transcribing DNA population comparable to that from proviral templates.

Evolution of SIV toward RANTES resistance in macaques rapidly progressing to AIDS upon coinfection with HHV-6A.

Immune suppression of human lymphoid tissues and cells in rotating suspension culture and onboard the International Space Station.

The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition.

Toxoplasma gondii inhibits R5 HIV-1 replication in human lymphoid tissues ex vivo.

A missed point in deciphering the viral synergy between herpes simplex virus and HIV.

Movements of HIV-virions in human cervical mucus.

Multisite comparison of anti-human immunodeficiency virus microbicide activity in explant assays using a novel endpoint analysis.

Acyclovir: a new use for an old drug.

War and peace between microbes: HIV-1 interactions with coinfecting viruses.

A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2.

HIV-1 sexual transmission: early events of HIV-1 infection of human cervico-vaginal tissue in an optimized ex vivo model.

Contrasting roles for TLR ligands in HIV-1 pathogenesis.

Determinants of protection among HIV‐exposed seronegative persons: an overview.

Cervico-vaginal tissue ex vivo as a model to study early events in HIV-1 infection.

Selective transmission of R5 HIV-1 variants: where is the gatekeeper?

CD4+ T cells, including Th17 and cycling subsets, are intact in the gut mucosa of HIV-1-infected long-term nonprogressors.

Activation of T lymphocytes in atherosclerotic plaques.

Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replication.

Semen of HIV-1-infected individuals: local shedding of herpesviruses and reprogrammed cytokine network.

Exploiting the anti-HIV-1 activity of acyclovir: suppression of primary and drug-resistant HIV isolates and potentiation of the activity by ribavirin.

HIV-1 is not a major driver of increased plasma IL-6 levels in chronic HIV-1 disease.

Microbicides: still a long road to success.

HIV-1 imposes rigidity on blood and semen cytokine networks.

HIV-1 expressing the envelopes of transmitted/founder or control/reference viruses have similar infection patterns of CD4 T-cells in human cervical tissue ex vivo.

It takes more than two for this tango.

Productive HIV-1 infection of human cervical tissue ex vivo is associated with the secretory phase of the menstrual cycle.

Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo.

Nanoparticle-based flow virometry for the analysis of individual virions.

A multi-targeted drug candidate with dual anti-HIV and anti-HSV activity.

Histocultures (tissue explants) in human retrovirology.

Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides.

HIV-1 vaginal transmission: cell-free or cell-associated virus?

A new antiviral: chimeric 3TC-AZT phosphonate efficiently inhibits HIV-1 in human tissues ex vivo.

Antigenic composition of single nano-sized extracellular blood vesicles.

Immunoactivation at the crossroads of human disease.

Valacyclovir Decreases Plasma HIV-1 RNA in HSV-2 Seronegative Individuals: A Randomized Placebo-Controlled Crossover Trial.

An ex vivo Model of HIV-1 Infection in Human Lymphoid Tissue and Cervico-vaginal Tissue.

Genital Cytomegalovirus Replication Predicts Syphilis Acquisition among HIV-1 Infected Men Who Have Sex with Men.

Evidence of perturbations of the cytokine network in preterm labor.

Distinct cytokine/chemokine network in semen and blood characterize different stages of HIV infection.

Evaluation of the maturation of individual Dengue virions with flow virometry.

Systemic inflammation and liver damage in HIV/hepatitis C virus coinfection.

Extracellular vesicles and viruses: Are they close relatives?

Modulation of Immune Responses by Extracellular Vesicles From Retinal Pigment Epithelium.

Cytomegalovirus-Productive Infection Is Associated With Acute Coronary Syndrome.

Monocytes but Not Lymphocytes Carrying HIV-1 on Their Surface Transmit Infection to Human Tissue Ex Vivo.

Flow analysis of individual blood extracellular vesicles in acute coronary syndrome.

Flow virometry analysis of envelope glycoprotein conformations on individual HIV virions.

Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue.

Vaginal Inhibits HIV-1 Replication in Human Tissues .

The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery.

A common anti-cytomegalovirus drug, ganciclovir, inhibits HIV-1 replication in human tissues ex vivo.

Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine.

Dual-targeted anti-TB/anti-HIV heterodimers.

Virtual Screening of Acyclovir Derivatives as Potential Antiviral Agents: Design, Synthesis, and Biological Evaluation of New Acyclic Nucleoside ProTides.

Addition of thrombin reduces the recovery of extracellular vesicles from blood plasma.

Ex vivo culture of human atherosclerotic plaques: A model to study immune cells in atherogenesis.

CD63, MHC class 1, and CD47 identify subsets of extracellular vesicles containing distinct populations of noncoding RNAs.

Histoculture and Infection with HIV of Functional Human Lymphoid Tissue on Gelfoam.

Extracellular vesicles generated by placental tissues ex vivo: A transport system for immune mediators and growth factors.

A System of Cytokines Encapsulated in ExtraCellular Vesicles.

Human cytomegalovirus-infected cells release extracellular vesicles that carry viral surface proteins.

Monocytes of Different Subsets in Complexes with Platelets in Patients with Myocardial Infarction.