Institute of Biochemistry and Molecular Medicine
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A GABA(A) receptor of defined subunit composition and positioning: concatenation of five subunits.
FEBS letters Mar, 2006 | Pubmed ID: 16494876
N-Substituted 4-amino-3,3-dipropyl-2(3H)-furanones: new positive allosteric modulators of the GABA(A) receptor sharing electrophysiological properties with the anticonvulsant loreclezole.
Journal of medicinal chemistry Jun, 2002 | Pubmed ID: 12061884
Functional characterization of the new human GABA(A) receptor mutation beta3(R192H).
Human genetics Aug, 2002 | Pubmed ID: 12189488
Forced subunit assembly in alpha1beta2gamma2 GABAA receptors. Insight into the absolute arrangement.
The Journal of biological chemistry Nov, 2002 | Pubmed ID: 12324466
Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi.
Biochemical pharmacology Nov, 2002 | Pubmed ID: 12392823
On high- and low-affinity agonist sites in GABAA receptors.
Journal of neurochemistry Oct, 2003 | Pubmed ID: 14511110
Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands.
Biochemical pharmacology Dec, 2003 | Pubmed ID: 14637197
Individual properties of the two functional agonist sites in GABA(A) receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2003 | Pubmed ID: 14657175
The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects.
British journal of pharmacology Jul, 2004 | Pubmed ID: 15231642
Benzodiazepines affect channel opening of GABA A receptors induced by either agonist binding site.
Molecular pharmacology Apr, 2005 | Pubmed ID: 15657366
Conformational changes at benzodiazepine binding sites of GABA(A) receptors detected with a novel technique.
Journal of neurochemistry Feb, 2005 | Pubmed ID: 15686488
Novel plant substances acting as beta subunit isoform-selective positive allosteric modulators of GABAA receptors.
Molecular pharmacology Sep, 2005 | Pubmed ID: 15939801
Homeopathic medical practice: long-term results of a cohort study with 3981 patients.
BMC public health Nov, 2005 | Pubmed ID: 16266440
Influence of the point mutation alpha-1-H101R on the assembly of gamma-aminobutyric acid type A receptors.
Neuroreport Nov, 2005 | Pubmed ID: 16272886
Consequence of the presence of two different beta subunit isoforms in a GABA(A) receptor.
Journal of neurochemistry Dec, 2005 | Pubmed ID: 16300645
Proximity-accelerated chemical coupling reaction in the benzodiazepine-binding site of gamma-aminobutyric acid type A receptors: superposition of different allosteric modulators.
The Journal of biological chemistry Sep, 2007 | Pubmed ID: 17626010
Two neighboring residues of loop A of the alpha1 subunit point towards the benzodiazepine binding site of GABAA receptors.
FEBS letters Oct, 2007 | Pubmed ID: 17854801
Replacement of histidine in position 105 in the α₅ subunit by cysteine stimulates zolpidem sensitivity of α₅β₂γ₂ GABA(A) receptors.
Journal of neurochemistry Dec, 2007 | Pubmed ID: 17953656
The promiscuous role of the epsilon subunit in GABAA receptor biogenesis.
Molecular and cellular neurosciences Mar, 2008 | Pubmed ID: 18206389
Novel chloride channel mutations leading to mild myotonia among Chinese.
Neuromuscular disorders : NMD Aug, 2008 | Pubmed ID: 18579381
Covalent modification of GABAA receptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs.
Journal of neurochemistry Sep, 2008 | Pubmed ID: 18643789
Unanticipated structural and functional properties of delta-subunit-containing GABAA receptors.
The Journal of biological chemistry Mar, 2009 | Pubmed ID: 19141615
Homeopathic treatment of patients with chronic low back pain: A prospective observational study with 2 years' follow-up.
The Clinical journal of pain May, 2009 | Pubmed ID: 19590483
Structure of alpha6 beta3 delta GABA(A) receptors and their lack of ethanol sensitivity.
Journal of neurochemistry Dec, 2009 | Pubmed ID: 19765192
Relative positioning of diazepam in the benzodiazepine-binding-pocket of GABA receptors.
Journal of neurochemistry Dec, 2009 | Pubmed ID: 19804380
Use of concatamers to study GABAA receptor architecture and function: application to delta-subunit-containing receptors and possible pitfalls.
Biochemical Society transactions Dec, 2009 | Pubmed ID: 19909272
Highly potent modulation of GABA(A) receptors by valerenic acid derivatives.
ChemMedChem May, 2010 | Pubmed ID: 20235267
Diversity of structure and function of alpha1alpha6beta3delta GABAA receptors: comparison with alpha1beta3delta and alpha6beta3delta receptors.
The Journal of biological chemistry Jun, 2010 | Pubmed ID: 20382738
Monepantel allosterically activates DEG-3/DES-2 channels of the gastrointestinal nematode Haemonchus contortus.
Molecular pharmacology Nov, 2010 | Pubmed ID: 20679419
A residue close to α1 loop F disrupts modulation of GABAA receptors by benzodiazepines while their binding is maintained.
Journal of neurochemistry Dec, 2010 | Pubmed ID: 20946417
The major central endocannabinoid directly acts at GABA(A) receptors.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2011 | Pubmed ID: 22025726
Influence of GABA(A) receptor α subunit isoforms on the benzodiazepine binding site.
PloS one , 2012 | Pubmed ID: 22848717
Molecular analysis of the site for 2-arachidonylglycerol (2-AG) on the β₂ subunit of GABA(A) receptors.
Journal of neurochemistry Jul, 2013 | Pubmed ID: 23600744
Effects and feasibility of an Integrative Medicine program for geriatric patients-a cluster-randomized pilot study.
Clinical interventions in aging , 2013 | Pubmed ID: 23901266
acr-23 Encodes a monepantel-sensitive channel in Caenorhabditis elegans.
PLoS pathogens , 2013 | Pubmed ID: 23950710
Dementia: treating patients and caregivers with complementary and alternative medicine--results of a clinical expert conference using the World Café method.
Forschende Komplementarmedizin (2006) , 2013 | Pubmed ID: 24030449
Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β2 subunit of GABAA receptors?
PeerJ , 2013 | Pubmed ID: 24058880
Accelerated discovery of novel benzodiazepine ligands by experiment-guided virtual screening.
ACS chemical biology Aug, 2014 | Pubmed ID: 24960548
Moderate concentrations of 4-O-methylhonokiol potentiate GABAA receptor currents stronger than honokiol.
Biochimica et biophysica acta Oct, 2014 | Pubmed ID: 24973566
A pentasymmetric open channel blocker for Cys-loop receptor channels.
PloS one , 2014 | Pubmed ID: 25184303
Monepantel irreversibly binds to and opens Haemonchus contortus MPTL-1 and Caenorhabditis elegans ACR-20 receptors.
Molecular pharmacology Jan, 2015 | Pubmed ID: 25352042
Structural analogues of the natural products magnolol and honokiol as potent allosteric potentiators of GABA(A) receptors.
Bioorganic & medicinal chemistry Dec, 2014 | Pubmed ID: 25456080
Positive modulation of synaptic and extrasynaptic GABAA receptors by an antagonist of the high affinity benzodiazepine binding site.
Neuropharmacology Aug, 2015 | Pubmed ID: 25963418
Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors.
Biochemistry research international , 2015 | Pubmed ID: 26509084
Functional sites involved in modulation of the GABAA receptor channel by the intravenous anesthetics propofol, etomidate and pentobarbital.
Neuropharmacology Jun, 2016 | Pubmed ID: 26767954
A new chromanone derivative isolated from Hypericum lissophloeus (Hypericaceae) potentiates GABAA receptor currents in a subunit specific fashion.
Bioorganic & medicinal chemistry Feb, 2016 | Pubmed ID: 26791864
Novel positive allosteric modulators of GABAA receptors with anesthetic activity.
Scientific reports May, 2016 | Pubmed ID: 27198062
Molecular mode of action of CGS 9895 at α1 β2 γ2 GABAA receptors.
Journal of neurochemistry Sep, 2016 | Pubmed ID: 27319298
Toward Understanding Functional Properties and Subunit Arrangement of α4β2δ γ-Aminobutyric Acid, Type A (GABAA) Receptors.
The Journal of biological chemistry Aug, 2016 | Pubmed ID: 27382064
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