Section on Neurobiology of Fear and Anxiety,
National Institute of Mental Health,
Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health
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Benzodiazepines have no effect on fear-potentiated startle in humans.
Psychopharmacology May, 2002 | Pubmed ID: 12021826
Associative learning deficits increase symptoms of anxiety in humans.
Biological psychiatry Jun, 2002 | Pubmed ID: 12022957
Startle reactivity and anxiety disorders: aversive conditioning, context, and neurobiology.
Biological psychiatry Nov, 2002 | Pubmed ID: 12437937
Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans.
Psychopharmacology Aug, 2003 | Pubmed ID: 12709777
Emotional arousal does not affect delay eyeblink conditioning.
Brain research. Cognitive brain research Jul, 2003 | Pubmed ID: 12880910
A review of the modulation of the startle reflex by affective states and its application in psychiatry.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Sep, 2003 | Pubmed ID: 12948786
Effects of the beta-blocker propranolol on cued and contextual fear conditioning in humans.
Psychopharmacology Sep, 2004 | Pubmed ID: 15007536
A neuroimaging method for the study of threat in adolescents.
Developmental psychobiology Dec, 2003 | Pubmed ID: 15027419
Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapy.
Neuroscience and biobehavioral reviews Mar, 2004 | Pubmed ID: 15036934
Fear conditioning in virtual reality contexts: a new tool for the study of anxiety.
Biological psychiatry Jun, 2004 | Pubmed ID: 15158423
Anxious responses to predictable and unpredictable aversive events.
Behavioral neuroscience Oct, 2004 | Pubmed ID: 15506874
Deficits in hippocampus-mediated Pavlovian conditioning in endogenous hypercortisolism.
Biological psychiatry Dec, 2004 | Pubmed ID: 15576060
Airpuff startle probes: an efficacious and less aversive alternative to white-noise.
Biological psychology Mar, 2005 | Pubmed ID: 15620795
Families at high and low risk for depression: a 3-generation study.
Archives of general psychiatry Jan, 2005 | Pubmed ID: 15630070
Electroencephalographic measures of regional hemispheric activity in offspring at risk for depressive disorders.
Biological psychiatry Feb, 2005 | Pubmed ID: 15705347
An investigation of prepulse inhibition in pediatric bipolar disorder.
Bipolar disorders Apr, 2005 | Pubmed ID: 15762862
Families at high and low risk for depression: a three-generation startle study.
Biological psychiatry May, 2005 | Pubmed ID: 15860334
Classical fear conditioning in the anxiety disorders: a meta-analysis.
Behaviour research and therapy Nov, 2005 | Pubmed ID: 15885654
Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorder.
Psychological medicine Jun, 2005 | Pubmed ID: 15997600
Cortisol and DHEA-S are associated with startle potentiation during aversive conditioning in humans.
Psychopharmacology Jun, 2006 | Pubmed ID: 16052364
Hydrocortisone impairs hippocampal-dependent trace eyeblink conditioning in post-traumatic stress disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Jan, 2006 | Pubmed ID: 16123770
Anticipation of public speaking in virtual reality reveals a relationship between trait social anxiety and startle reactivity.
Biological psychiatry Apr, 2006 | Pubmed ID: 16325155
The strong situation: a potential impediment to studying the psychobiology and pharmacology of anxiety disorders.
Biological psychology Jun, 2006 | Pubmed ID: 16343731
Sensation seeking and the aversive motivational system.
Emotion (Washington, D.C.) Dec, 2005 | Pubmed ID: 16366744
Brainstem correlates of defensive states in humans.
Biological psychiatry Apr, 2006 | Pubmed ID: 16388780
Using affect-modulated startle to study phenotypes of pediatric bipolar disorder.
Bipolar disorders Dec, 2005 | Pubmed ID: 16403179
The benzodiazepine alprazolam dissociates contextual fear from cued fear in humans as assessed by fear-potentiated startle.
Biological psychiatry Oct, 2006 | Pubmed ID: 16631127
Context conditioning and behavioral avoidance in a virtual reality environment: effect of predictability.
Biological psychiatry Oct, 2006 | Pubmed ID: 16950216
Attentional blink and prepulse inhibition of startle are positively correlated.
Psychophysiology Sep, 2006 | Pubmed ID: 16965613
A single dose of the selective serotonin reuptake inhibitor citalopram exacerbates anxiety in humans: a fear-potentiated startle study.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Jan, 2007 | Pubmed ID: 16971899
Reduction of trace but not delay eyeblink conditioning in panic disorder.
The American journal of psychiatry Feb, 2007 | Pubmed ID: 17267792
Luteal-phase accentuation of acoustic startle response in women with premenstrual dysphoric disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Oct, 2007 | Pubmed ID: 17314917
Contextual-specificity of short-delay extinction in humans: renewal of fear-potentiated startle in a virtual environment.
Learning & memory (Cold Spring Harbor, N.Y.) Apr, 2007 | Pubmed ID: 17412963
Sensitivity to masked conditioned stimuli predicts conditioned response magnitude under masked conditions.
Psychophysiology May, 2007 | Pubmed ID: 17433097
Acute exposure to stress improves performance in trace eyeblink conditioning and spatial learning tasks in healthy men.
Learning & memory (Cold Spring Harbor, N.Y.) May, 2007 | Pubmed ID: 17522023
Comments on Fearful and sexual pictures not consciously seen modulate the startle reflex in human beings.
Biological psychiatry Sep, 2007 | Pubmed ID: 17531204
Fear-potentiated startle to threat, and prepulse inhibition among young adult nonsmokers, abstinent smokers, and nonabstinent smokers.
Biological psychiatry Nov, 2007 | Pubmed ID: 17543892
Cerebral blood flow in immediate and sustained anxiety.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2007 | Pubmed ID: 17554005
Neural responses to auditory stimulus deviance under threat of electric shock revealed by spatially-filtered magnetoencephalography.
NeuroImage Aug, 2007 | Pubmed ID: 17566766
Startle potentiation in rapidly alternating conditions of high and low predictability of threat.
Biological psychology Sep, 2007 | Pubmed ID: 17644240
Emotion regulation and potentiated startle across affective picture and threat-of-shock paradigms.
Biological psychology Sep, 2007 | Pubmed ID: 17692453
Acute stress potentiates anxiety in humans.
Biological psychiatry Nov, 2007 | Pubmed ID: 17692829
Elevated fear conditioning to socially relevant unconditioned stimuli in social anxiety disorder.
The American journal of psychiatry Jan, 2008 | Pubmed ID: 18006874
Models and mechanisms of anxiety: evidence from startle studies.
Psychopharmacology Aug, 2008 | Pubmed ID: 18058089
Fear conditioning in adolescents with anxiety disorders: results from a novel experimental paradigm.
Journal of the American Academy of Child and Adolescent Psychiatry Jan, 2008 | Pubmed ID: 18174830
Increased anxiety during anticipation of unpredictable but not predictable aversive stimuli as a psychophysiologic marker of panic disorder.
The American journal of psychiatry Jul, 2008 | Pubmed ID: 18347001
It is time to take a stand for medical research and against terrorism targeting medical scientists.
Biological psychiatry Apr, 2008 | Pubmed ID: 18371494
Generalization of conditioned fear-potentiated startle in humans: experimental validation and clinical relevance.
Behaviour research and therapy May, 2008 | Pubmed ID: 18394587
Contextual specificity of extinction of delay but not trace eyeblink conditioning in humans.
Learning & memory (Cold Spring Harbor, N.Y.) Jun, 2008 | Pubmed ID: 18509111
Human hippocampal and parahippocampal theta during goal-directed spatial navigation predicts performance on a virtual Morris water maze.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2008 | Pubmed ID: 18524903
Greater sustained anxiety but not phasic fear in women compared to men.
Emotion (Washington, D.C.) Jun, 2008 | Pubmed ID: 18540756
Contextual fear conditioning in humans: cortical-hippocampal and amygdala contributions.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2008 | Pubmed ID: 18550763
Modality-specific attention under imminent but not remote threat of shock: evidence from differential prepulse inhibition of startle.
Psychological science Jun, 2008 | Pubmed ID: 18578853
Two-week treatment with the selective serotonin reuptake inhibitor citalopram reduces contextual anxiety but not cued fear in healthy volunteers: a fear-potentiated startle study.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Mar, 2009 | Pubmed ID: 18800069
Increased anterior cingulate cortical activity in response to fearful faces: a neurophysiological biomarker that predicts rapid antidepressant response to ketamine.
Biological psychiatry Feb, 2009 | Pubmed ID: 18822408
Evoked amygdala responses to negative faces revealed by adaptive MEG beamformers.
Brain research Dec, 2008 | Pubmed ID: 18930036
Startle reactivity in children at risk for migraine.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Dec, 2008 | Pubmed ID: 18951839
Impaired discriminative fear-conditioning resulting from elevated fear responding to learned safety cues among individuals with panic disorder.
Behaviour research and therapy Feb, 2009 | Pubmed ID: 19027893
Increased anxiety during anticipation of unpredictable aversive stimuli in posttraumatic stress disorder but not in generalized anxiety disorder.
Biological psychiatry Jul, 2009 | Pubmed ID: 19217076
Working memory performance after acute exposure to the cold pressor stress in healthy volunteers.
Neurobiology of learning and memory May, 2009 | Pubmed ID: 19340949
Startle response in behaviorally inhibited adolescents with a lifetime occurrence of anxiety disorders.
Journal of the American Academy of Child and Adolescent Psychiatry Jun, 2009 | Pubmed ID: 19454917
D-cycloserine facilitation of fear extinction and exposure-based therapy might rely on lower-level, automatic mechanisms.
Biological psychiatry Oct, 2009 | Pubmed ID: 19520359
Impaired spatial navigation in pediatric anxiety.
Journal of child psychology and psychiatry, and allied disciplines Oct, 2009 | Pubmed ID: 19594834
Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Jan, 2010 | Pubmed ID: 19693004
Overgeneralization of conditioned fear as a pathogenic marker of panic disorder.
The American journal of psychiatry Jan, 2010 | Pubmed ID: 19917595
Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamine.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Jun, 2010 | Pubmed ID: 20393460
Abnormal hippocampal functioning and impaired spatial navigation in depressed individuals: evidence from whole-head magnetoencephalography.
The American journal of psychiatry Jul, 2010 | Pubmed ID: 20439387
Effect of acute psychological stress on prefrontal GABA concentration determined by proton magnetic resonance spectroscopy.
The American journal of psychiatry Oct, 2010 | Pubmed ID: 20634372
Development of anxiety: the role of threat appraisal and fear learning.
Depression and anxiety Jan, 2011 | Pubmed ID: 20734364
Becoming the center of attention in social anxiety disorder: startle reactivity to a virtual audience during speech anticipation.
The Journal of clinical psychiatry Jul, 2011 | Pubmed ID: 21034683
Phasic and sustained fear in humans elicits distinct patterns of brain activity.
NeuroImage Mar, 2011 | Pubmed ID: 21111828
Acute hydrocortisone treatment increases anxiety but not fear in healthy volunteers: a fear-potentiated startle study.
Biological psychiatry Mar, 2011 | Pubmed ID: 21277566
Distinct neural signatures of threat learning in adolescents and adults.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2011 | Pubmed ID: 21368210
Anxiety overrides the blocking effects of high perceptual load on amygdala reactivity to threat-related distractors.
Neuropsychologia Apr, 2011 | Pubmed ID: 21376745
Measuring anxious responses to predictable and unpredictable threat in children and adolescents.
Journal of experimental child psychology Oct, 2011 | Pubmed ID: 21440905
The effect of induced anxiety on cognition: threat of shock enhances aversive processing in healthy individuals.
Cognitive, affective & behavioral neuroscience Jun, 2011 | Pubmed ID: 21484411
In the face of fear: anxiety sensitizes defensive responses to fearful faces.
Psychophysiology Dec, 2011 | Pubmed ID: 21824155
The adaptive threat bias in anxiety: amygdala-dorsomedial prefrontal cortex coupling and aversive amplification.
NeuroImage Mar, 2012 | Pubmed ID: 22178453
Anxiety, a benefit and detriment to cognition: behavioral and magnetoencephalographic evidence from a mixed-saccade task.
Brain and cognition Apr, 2012 | Pubmed ID: 22289426
Describing the interplay between anxiety and cognition: from impaired performance under low cognitive load to reduced anxiety under high load.
Psychophysiology Jun, 2012 | Pubmed ID: 22332819
Testing the effects of Δ9-THC and D-cycloserine on extinction of conditioned fear in humans.
Journal of psychopharmacology (Oxford, England) Apr, 2012 | Pubmed ID: 22351380
Assessing fear and anxiety in humans using the threat of predictable and unpredictable aversive events (the NPU-threat test).
Nature protocols Feb, 2012 | Pubmed ID: 22362158
Through the eyes of anxiety: Dissecting threat bias via emotional-binocular rivalry.
Emotion (Washington, D.C.) Oct, 2012 | Pubmed ID: 22390706
Distinct contributions of human hippocampal theta to spatial cognition and anxiety.
Hippocampus Sep, 2012 | Pubmed ID: 22467298
Acute tryptophan depletion increases translational indices of anxiety but not fear: serotonergic modulation of the bed nucleus of the stria terminalis?
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Jul, 2012 | Pubmed ID: 22491355
Synaptic potentiation is critical for rapid antidepressant response to ketamine in treatment-resistant major depression.
Biological psychiatry Oct, 2012 | Pubmed ID: 22521148
Enhanced discrimination between threatening and safe contexts in high-anxious individuals.
Biological psychology Apr, 2013 | Pubmed ID: 23384512
Stress increases aversive prediction error signal in the ventral striatum.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2013 | Pubmed ID: 23401511
Passive avoidance is linked to impaired fear extinction in humans.
Learning & memory (Cold Spring Harbor, N.Y.) Feb, 2013 | Pubmed ID: 23427168
The impact of induced anxiety on response inhibition.
Frontiers in human neuroscience , 2013 | Pubmed ID: 23471118
The complex interaction between anxiety and cognition: insight from spatial and verbal working memory.
Frontiers in human neuroscience , 2013 | Pubmed ID: 23542914
The role of serotonin in the neurocircuitry of negative affective bias: serotonergic modulation of the dorsal medial prefrontal-amygdala 'aversive amplification' circuit.
NeuroImage Sep, 2013 | Pubmed ID: 23583742
The impact of anxiety upon cognition: perspectives from human threat of shock studies.
Frontiers in human neuroscience , 2013 | Pubmed ID: 23730279
Neural substrates of classically conditioned fear-generalization in humans: a parametric fMRI study.
Social cognitive and affective neuroscience Aug, 2014 | Pubmed ID: 23748500
Response to learned threat: An FMRI study in adolescent and adult anxiety.
The American journal of psychiatry Oct, 2013 | Pubmed ID: 23929092
Major depression is not associated with blunting of aversive responses; evidence for enhanced anxious anticipation.
PloS one , 2013 | Pubmed ID: 23951057
Generalized anxiety disorder is associated with overgeneralization of classically conditioned fear.
Biological psychiatry Jun, 2014 | Pubmed ID: 24001473
Developmental investigation of fear-potentiated startle across puberty.
Biological psychology Mar, 2014 | Pubmed ID: 24334108
Evidence of MAOA genotype involvement in spatial ability in males.
Behavioural brain research Jul, 2014 | Pubmed ID: 24671068
Increased fear-potentiated startle in major depressive disorder patients with lifetime history of suicide attempt.
Journal of affective disorders Jun, 2014 | Pubmed ID: 24767002
Understanding placebo and nocebo responses for pain management.
Current pain and headache reports Jun, 2014 | Pubmed ID: 24771206
Sustained anxiety increases amygdala-dorsomedial prefrontal coupling: a mechanism for maintaining an anxious state in healthy adults.
Journal of psychiatry & neuroscience : JPN Sep, 2014 | Pubmed ID: 24886788
Pain and placebo in pediatrics: a comprehensive review of laboratory and clinical findings.
Pain Nov, 2014 | Pubmed ID: 25180010
The CRH1 antagonist GSK561679 increases human fear but not anxiety as assessed by startle.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Mar, 2015 | Pubmed ID: 25430779
Oxytocin and vasopressin modulate risk-taking.
Physiology & behavior Feb, 2015 | Pubmed ID: 25446228
fMRI functional connectivity applied to adolescent neurodevelopment.
Annual review of clinical psychology , 2015 | Pubmed ID: 25581237
Mental fatigue impairs emotion regulation.
Emotion (Washington, D.C.) Jun, 2015 | Pubmed ID: 25706833
Towards a mechanistic understanding of pathological anxiety: the dorsal medial prefrontal-amygdala 'aversive amplification' circuit in unmedicated generalized and social anxiety disorders.
The lancet. Psychiatry Sep, 2014 | Pubmed ID: 25722962
Effect of attention control on sustained attention during induced anxiety.
Cognition & emotion , 2016 | Pubmed ID: 25899613
Resting state connectivity of the bed nucleus of the stria terminalis at ultra-high field.
Human brain mapping Oct, 2015 | Pubmed ID: 26178381
Vasopressin Boosts Placebo Analgesic Effects in Women: A Randomized Trial.
Biological psychiatry May, 2016 | Pubmed ID: 26321018
Effect of anxiety on behavioural pattern separation in humans.
Cognition & emotion Feb, 2017 | Pubmed ID: 26480349
Interaction of threat and verbal working memory in adolescents.
Psychophysiology Apr, 2016 | Pubmed ID: 26589772
Age and Social Context Modulate the Effect of Anxiety on Risk-taking in Pediatric Samples.
Journal of abnormal child psychology 08, 2016 | Pubmed ID: 26659306
Abnormal decision-making in generalized anxiety disorder: Aversion of risk or stimulus-reinforcement impairment?
Psychiatry research Mar, 2016 | Pubmed ID: 26822065
Induced-anxiety differentially disrupts working memory in generalized anxiety disorder.
BMC psychiatry Mar, 2016 | Pubmed ID: 26976146
Anxiety Patients Show Reduced Working Memory Related dlPFC Activation During Safety and Threat.
Depression and anxiety Jan, 2017 | Pubmed ID: 27110997
Striatum on the anxiety map: Small detours into adolescence.
Brain research Jan, 2017 | Pubmed ID: 27276526
The neural basis of improved cognitive performance by threat of shock.
Social cognitive and affective neuroscience Nov, 2016 | Pubmed ID: 27369069
Working memory maintenance is sufficient to reduce state anxiety.
Psychophysiology Nov, 2016 | Pubmed ID: 27434207
The effects of methylphenidate and propranolol on the interplay between induced-anxiety and working memory.
Psychopharmacology Oct, 2016 | Pubmed ID: 27492789
Gain in Translation: Is It Time for Thigmotaxis Studies in Humans?
Biological psychiatry Sep, 2016 | Pubmed ID: 27499012
Prediction Error Representation in Individuals With Generalized Anxiety Disorder During Passive Avoidance.
The American journal of psychiatry Feb, 2017 | Pubmed ID: 27631963
Altered Pain Perception and Fear-Learning Deficits in Subjects With Posttraumatic Stress Disorder.
The journal of pain : official journal of the American Pain Society Dec, 2016 | Pubmed ID: 27641312
Anxiety-mediated facilitation of behavioral inhibition: Threat processing and defensive reactivity during a go/no-go task.
Emotion (Washington, D.C.) 03, 2017 | Pubmed ID: 27642657
Resting state connectivity of the human habenula at ultra-high field.
NeuroImage Feb, 2017 | Pubmed ID: 27780778
Intrinsic functional connectivity of the central nucleus of the amygdala and bed nucleus of the stria terminalis.
NeuroImage Apr, 2017 | Pubmed ID: 28392491
Threat of shock increases excitability and connectivity of the intraparietal sulcus.
eLife May, 2017 | Pubmed ID: 28555565
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