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An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging

The possibility to perform an early and repeatable assessment of imaging performance is fundamental in the design and development process of new ...

Roma Tre University

Medical ultrasonography is a powerful and cost-effective diagnostic technique. To date, high-end medical imaging systems are able to efficiently implement real-time image formation techniques that can dramatically improve the diagnostic capabilities of ultrasound. Highly performing and thermally efficient ultrasound probes are then required to successfully enable the most advanced techniques. In this context, ultrasound transducer technology is the current limiting factor. Capacitive micromachined ultrasonic transducers (CMUTs) are micro-electro-mechanical systems (MEMS)-based devices that have been widely recognized as a valuable alternative to piezoelectric transducer technology in a variety of medical imaging applications. Wideband operation, good thermal efficiency, and low fabrication cost, especially for those applications requiring high-volume production of small-area dice, are strength factors that may justify the adoption of this MEMS technology in the medical ultrasound imaging field. This paper presents the design, development, fabrication, and characterization of a 12-MHz ultrasound probe for medical imaging, based on a CMUT array. The CMUT array is microfabricated and packed using a novel fabrication concept specifically conceived for imaging transducer arrays. The performance of the developed probe is optimized by including analog front-end reception electronics. Characterization and imaging results are used to assess the performance of CMUTs with respect to conventional piezoelectric transducers.

A CMUT probe for medical ultrasonography: from microfabrication to system integration.

Most of ultrasound medical imaging systems currently on the market implement standard Delay and Sum (DAS) beamforming to form B-mode images. However, image resolution and contrast achievable with DAS are limited by the aperture size and by the operating frequency. For this reason, different beamformers have been presented in the literature that are mainly based on adaptive algorithms, which allow achieving higher performance at the cost of an increased computational complexity. In this paper, we propose the use of an alternative nonlinear beamforming algorithm for medical ultrasound imaging, which is called Delay Multiply and Sum (DMAS) and that was originally conceived for a RADAR microwave system for breast cancer detection. We modify the DMAS beamformer and test its performance on both simulated and experimentally collected linear-scan data, by comparing the Point Spread Functions, beampatterns, synthetic phantom and in vivo carotid artery images obtained with standard DAS and with the proposed algorithm. Results show that the DMAS beamformer outperforms DAS in both simulated and experimental trials and that the main improvement brought about by this new method is a significantly higher contrast resolution (i.e., narrower main lobe and lower side lobes), which turns out into an increased dynamic range and better quality of B-mode images.

The delay multiply and sum beamforming algorithm in ultrasound B-mode medical imaging.

The current high interest in 3-D ultrasound imaging is pushing the development of 2-D probes with a challenging number of active elements. The most popular approach to limit this number is the sparse array technique, which designs the array layout by means of complex optimization algorithms. These algorithms are typically constrained by a few steering conditions, and, as such, cannot guarantee uniform side-lobe performance at all angles. The performance may be improved by the ungridded extensions of the sparse array technique, but this result is achieved at the expense of a further complication of the optimization process. In this paper, a method to design the layout of large circular arrays with a limited number of elements according to Fermat's spiral seeds and spatial density modulation is proposed and shown to be suitable for application to 3-D ultrasound imaging. This deterministic, aperiodic, and balanced positioning procedure attempts to guarantee uniform performance over a wide range of steering angles. The capabilities of the method are demonstrated by simulating and comparing the performance of spiral and dense arrays. A good trade-off for small vessel imaging is found, e.g., in the 60λ spiral array with 1.0λ elements and Blackman density tapering window. Here, the grating lobe level is -16 dB, the lateral resolution is lower than 6λ the depth of field is 120λ and, the average contrast is 10.3 dB, while the sensitivity remains in a 5 dB range for a wide selection of steering angles. The simulation results may represent a reference guide to the design of spiral sparse array probes for different application fields.

Density-tapered spiral arrays for ultrasound 3-D imaging.

In this paper, we propose the design and the fabrication of a multicell, piezoelectrically actuated, flextensional transducer array structure, characterized by a low mechanical impedance, thus allowing wideband and high-sensitivity immersion operation in the low ultrasonic frequency range. The transducer structure, consisting of a plurality of circular elementary cells orderly arranged according to a periodic hexagonal tiling, features a high flexibility in the definition of the active area shape and size. We investigate, by finite element modeling (FEM), the influence of different piezoelectric and elastic materials for the flexural plate, for the plate support and for the backing, on the transducer electroacoustic behavior. We carry out the dimensioning of the transducer components and cell layout, in terms of materials and geometry, respectively, by aiming at a circular active area of 80-mm diameter and broadband operation in the 30-100-kHz frequency range in immersion. PZT-5H ceramic disks and a calibrated thickness stainless steel plate are chosen for the vibrating structure, and FR-4 laminates and a brass plate, respectively, for the plate support and the backing. The diameter of the individual cells is set to 6 mm resulting in 121 cells describing a quasi-circular area, and the total thickness of the transducer is less than 10 mm. We report on the fabrication process flow for the accurate assembly of the transducer, based, respectively, on epoxy resin and wire bonding for the mechanical and electrical interconnection of the individual parts. The results of the electrical impedance and transmit pressure field characterization are finally reported and discussed.

A Low Frequency Broadband Flextensional Ultrasonic Transducer Array.

The Delay Multiply and Sum (DMAS) beamforming algorithm was originally conceived for microwave imaging of breast cancer. In a previous work, we demonstrated that, by properly modifying and improving the algorithm processing steps, DMAS can be successfully applied to ultrasound signals for B-mode image formation and that it outperforms standard Delay and Sum (DAS) beamforming in terms of contrast resolution. As previously pointed out, however, DMAS-beamformed B-mode images, in which fixed and dynamic focusing are applied respectively during transmit and receive operations, show an intensity drop away from the transmit focal depth compared to DAS images. This could be due to the fact that DMAS beamforming is based on a measure of backscattered signal coherence, which reaches its maximum only at the transmit focus, where signals are perfectly realigned. The preliminary results presented in this work show that, by employing Synthetic Aperture Focusing (SAF), which allows to achieve dynamic focusing both on transmission and reception, this intensity loss is compensated, as DAS and DMAS images have almost the same maximum amplitude level at all depths.

Ultrasound Synthetic Aperture Focusing with the Delay Multiply and sum beamforming algorithm.

Capacitive micromachined ultrasonic transducers (CMUTs) represent an effective alternative to piezoelectric transducers for medical ultrasound imaging applications. They are microelectromechanical devices fabricated using silicon micromachining techniques, developed in the last two decades in many laboratories. The interest for this novel transducer technology relies on its full compatibility with standard integrated circuit technology that makes it possible to integrate on the same chip the transducers and the electronics, thus enabling the realization of extremely low-cost and high-performance devices, including both 1-D or 2-D arrays. Being capacitive transducers, CMUTs require a high bias voltage to be properly operated in pulse-echo imaging applications. The typical bias supply residual ripple of high-quality high-voltage (HV) generators is in the millivolt range, which is comparable with the amplitude of the received echo signals, and it is particularly difficult to minimize. The aim of this paper is to analyze the classical CMUT biasing circuits, highlighting the features of each one, and to propose two novel HV generator architectures optimized for CMUT biasing applications. The first circuit proposed is an ultralow-residual ripple (<5 [Formula: see text]) HV generator that uses an extremely stable sinusoidal power oscillator topology. The second circuit employs a commercially available integrated step-up converter characterized by a particularly efficient switching topology. The circuit is used to bias the CMUT by charging a buffer capacitor synchronously with the pulsing sequence, thus reducing the impact of the switching noise on the received echo signals. The small area of the circuit (about 1.5 cm(2)) makes it possible to generate the bias voltage inside the probe, very close to the CMUT, making the proposed solution attractive for portable applications. Measurements and experiments are shown to demonstrate the effectiveness of the new approaches presented.

Biasing of Capacitive Micromachined Ultrasonic Transducers.

The Synthetic Aperture Focusing (SAF) technique makes it possible to achieve a higher and more uniform quality of ultrasound images throughout depth, as if both transmit and receive dynamic focusing were applied. In this work we combine a particular implementation of SAF, called Synthetic Transmit Aperture (STA) technique, in which a single element in turn transmits and all the array elements receive the ultrasound wave, with the Filtered-Delay Multiply and Sum (F-DMAS) non-linear beamforming algorithm that we presented in a previous paper. We show that using F-DMAS, which is based on a measure of backscattered signal spatial correlation, B-mode images have a higher contrast resolution but suffer from a loss of brightness away from the transmit focus, when a classical scan with receive-only dynamic focusing is performed. On the other hand, when synthetic transmit focusing is achieved by implementing STA, such a loss is compensated for and a higher depth of field is obtained, as signal coherence improves. A drawback of SAF/STA however is the reduced signal-to-noise ratio, due to single-element transmission; in the paper we also analyze how this influences F-DMAS images. Finally, a preliminary investigation on the use of the classical monostatic SAF technique with F-DMAS beamforming is also carried out to evaluate its potential performances.

Depth-of-field enhancement in Filtered-Delay Multiply and Sum beamformed images using Synthetic Aperture Focusing.

Multi-Line Transmission (MLT) was recently demonstrated as a valuable tool to increase the frame rate of ultrasound images. In this approach, the multiple beams that are simultaneously transmitted may determine cross-talk artifacts that are typically reduced, although not eliminated, by the use of Tukey apodization on both transmission and reception apertures, which unfortunately worsens the image lateral resolution. In this paper we investigate the combination, and related performance, of Filtered-Delay Multiply And Sum (F-DMAS) beamforming with MLT for high frame-rate ultrasound imaging. F-DMAS is a non-linear beamformer based on the computation of the receive aperture spatial autocorrelation, which was recently proposed for use in ultrasound B-mode imaging by some of the authors. The main advantages of such beamformer are the improved contrast resolution, obtained by lowering the beam side lobes and narrowing the main lobe, and the increased noise rejection. This study shows that in MLT images, compared to standard Delay And Sum (DAS) beamforming including Tukey apodization, F-DMAS beamforming yields better suppression of cross-talk and improved lateral resolution. The method's effectiveness is demonstrated by simulations and phantom experiments. Preliminary in vivo cardiac images also show that the frame rate can be improved up to 8-fold by combining F-DMAS and MLT without affecting the image quality.

High Frame-Rate, High Resolution Ultrasound Imaging With Multi-Line Transmission and Filtered-Delay Multiply And Sum Beamforming.

A formal comparison between fundamental RX amplifier configurations for capacitive micromachined ultrasonic transducers (CMUTs) is proposed in this paper. The impact on both RX and the pulse-echo frequency response and on the output SNR is thoroughly analyzed and discussed. It is shown that the resistive-feedback amplifier yields a bandpass RX frequency response, while both open-loop voltage and capacitive-feedback amplifiers exhibit a low-pass frequency response. For a given power dissipation, it is formally proved that a capacitive-feedback amplifier provides a remarkable SNR improvement against the commonly adopted resistive feedback stage, achieved at the expense of a reduced pulse-echo center frequency, making its use convenient in low-frequency and midfrequency ultrasound imaging applications. The advantage mostly comes from a much lower noise contributed by the active devices, especially with low- Q , broadband transducers. The results of the analysis are applied to the design of a CMUT front end in BIPOLAR-CMOS-DMOS Silicon-on-Insulator technology operating at 10-MHz center frequency. It comprises a low-power RX amplifier, a high-voltage Transmission/Reception switch, and a 100-V TX driver. Extensive electrical characterization, pulse-echo measurements, and imaging results are shown. Compared with previously reported CMUT front ends, this transceiver demonstrates the highest dynamic range and state-of-the-art noise performance with an RX amplifier power dissipation of 1 mW.

Alessandro Stuart Savoia

Department of Engineering

Roma Tre University

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging

Alessandro Stuart Savoia

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Department of Engineering

Roma Tre University

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging

Department of Engineering