Stefan Lehr

Primary skin fibroblasts as human model system for proteome analysis.

Reliability of EMG time-frequency measures of fatigue during repetitive lifting.

Insulin-activated Erk-mitogen-activated protein kinases phosphorylate sterol regulatory element-binding Protein-2 at serine residues 432 and 455 in vivo.

Identification of major ERK-related phosphorylation sites in Gab1.

Effect of sterol regulatory element binding protein-1a on the mitochondrial protein pattern in human liver cells detected by 2D-DIGE.

Glucuronic acid can extend O-linked core 1 glycans, but it contributes only weakly to the negative surface charge of Drosophila melanogaster Schneider-2 cells.

A critical comparison between two classical and a kit-based method for mitochondria isolation.

Combinatorial hexapeptide ligand libraries (ProteoMiner): an innovative fractionation tool for differential quantitative clinical proteomics.

Enhancing mass spectrometry based serum profiling by a combination of free flow electrophoresis and ClinProt.

Proteomics in health and disease.

Validation of self-made fluorescent cyanine dyes for 2D gel-based multi-fluorescence protein analysis.

Mass spectrometry-based proteomics and its potential use in haematological research.

ProteoMiner™ and SELDI-TOF-MS: a robust and highly reproducible combination for biomarker discovery from whole blood serum.

Targeting phosphoprotein profiling by combination of hydroxyapatite-based phosphoprotein enrichment and SELDI-TOF MS.

Biomarker discovery using SELDI-TOF protein chip technology.

Integrative proteomics for the future US HUPO Fifth Annual Conference from genes to function 22-25 February 2009, San Diego, CA, USA.

Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome.

The non-steroidal anti-inflammatory drugs Sulindac sulfide and Diclofenac induce apoptosis and differentiation in human acute myeloid leukemia cells through an AP-1 dependent pathway.

Identification and validation of novel adipokines released from primary human adipocytes.

Qualitative characteristics of HDL in young patients of an acute myocardial infarction.

Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders.

Multifluorescence 2D gel imaging and image analysis.

Combination of highly efficient hexapeptide ligand library-based sample preparation with 2D DIGE for the analysis of the hidden human serum/plasma proteome.

Chemerin as biomarker for insulin sensitivity in males without typical characteristics of metabolic syndrome.

Sex steroid-induced changes in circulating monocyte chemoattractant protein-1 levels may contribute to metabolic dysfunction in obese men.

Genetic variants in central metabolic genes influence some but not all relations of inflammatory markers in a collective with polycystic ovary syndrome.

Multiplex immunoassays: an invaluable tool for biomarker discovery and validation.

Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.

2D-ToGo workflow: increasing feasibility and reproducibility of 2-dimensional gel electrophoresis.

So close and yet so far: mitochondria and peroxisomes are one but with specific talents.

The impact of pre-analytical conditions on the serum proteome: heat-stabilization versus nitrogen storage.

2-dimensional gel electrophoresis reloaded.

A mutation in the c-fos gene associated with congenital generalized lipodystrophy.

Cytokine response of primary human myotubes in an in vitro exercise model.

Secretome profiling of primary human skeletal muscle cells.

The secretome of the working human skeletal muscle--a promising opportunity to combat the metabolic disaster?

Profiling of low molecular weight proteins in plasma from locally irradiated individuals.

Interleukin-6-dependent phenotypic modulation of cardiac fibroblasts after acute myocardial infarction.

Identification of novel adipokines differential regulated in C57BL/Ks and C57BL/6.

Proteomics in practice.

Phosphorylation of sterol regulatory element-binding protein (SREBP)-1c by p38 kinases, ERK and JNK influences lipid metabolism and the secretome of human liver cell line HepG2.

Preparation of "functional" mitochondria: a challenging business.

Isolation and quality control of functional mitochondria.

Deficiency in lymphotoxin β receptor protects from atherosclerosis in apoE-deficient mice.

Peroxisomes compensate hepatic lipid overflow in mice with fatty liver.

Investigating the adipose tissue secretome: a protocol to generate high-quality samples appropriate for comprehensive proteomic profiling.

Methods for proteomics-based analysis of the human muscle secretome using an in vitro exercise model.

Deep serum discoveries: SDF-1α and HSA fragments in myelodysplastic syndromes.

Increased cathepsin D protein expression is a biomarker for osteosarcomas, pulmonary metastases and other bone malignancies.

Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice.

Specific Metabolic Profiles and Their Relationship to Insulin Resistance in Recent-Onset Type 1 and Type 2 Diabetes.

Untargeted mass spectrometric approach in metabolic healthy offspring of patients with type 2 diabetes reveals medium-chain acylcarnitine as potential biomarker for lipid induced glucose intolerance (LGIT).

Impact of fibroblast growth factor 21 on the secretome of human perivascular preadipocytes and adipocytes: a targeted proteomics approach.

Oxygen and differentiation status modulate the effect of X-ray irradiation on physiology and mitochondrial proteome of human neuroblastoma cells.

Mass spectrometry in life science research.

Lipidomics-Reshaping the Analysis and Perception of Type 2 Diabetes.

Association between copy-number variation on metabolic phenotypes and HDL-C levels in patients with polycystic ovary syndrome.

Differential Patterns of Impaired Cardiorespiratory Fitness and Cardiac Autonomic Dysfunction in Recently Diagnosed Type 1 and Type 2 Diabetes.

Mechanisms of Insulin Resistance in Primary and Secondary Non-Alcoholic Fatty Liver.