Department of Molecular Physiology and Biophysics,
Robert M. Berne Cardiovascular Research Center
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Culturing alveolar type I, alveolar type II, and mixed cell populations by altering the extracellular matrix promotes changes in intercellular signaling mechanisms.
Chest Mar, 2002 | Pubmed ID: 11893676
Heterocellular cultures of pulmonary alveolar epithelial cells grown on laminin-5 supplemented matrix.
In vitro cellular & developmental biology. Animal Sep, 2002 | Pubmed ID: 12605538
Cell-cell communication in heterocellular cultures of alveolar epithelial cells.
American journal of respiratory cell and molecular biology Nov, 2003 | Pubmed ID: 12748060
Connexins: gaps in our knowledge of vascular function.
Physiology (Bethesda, Md.) Oct, 2004 | Pubmed ID: 15381756
Heterocellular contact at the myoendothelial junction influences gap junction organization.
Circulation research Jul, 2005 | Pubmed ID: 15961721
Extracellular matrix-driven alveolar epithelial cell differentiation in vitro.
Experimental lung research Jun, 2005 | Pubmed ID: 16047415
Connexin40 and connexin43 in mouse aortic endothelium: evidence for coordinated regulation.
American journal of physiology. Heart and circulatory physiology Mar, 2006 | Pubmed ID: 16284228
Oxidized phospholipids alter vascular connexin expression, phosphorylation, and heterocellular communication.
Arteriosclerosis, thrombosis, and vascular biology Oct, 2006 | Pubmed ID: 16857951
Laminin-332 alters connexin profile, dye coupling and intercellular Ca2+ waves in ciliated tracheal epithelial cells.
Respiratory research Aug, 2006 | Pubmed ID: 16884540
Vascular gap junctions in hypertension.
Hypertension (Dallas, Tex. : 1979) Nov, 2006 | Pubmed ID: 17015783
Ca2+ and inositol 1,4,5-trisphosphate-mediated signaling across the myoendothelial junction.
Circulation research Feb, 2007 | Pubmed ID: 17218602
Incidence of protein on actin bridges between endothelium and smooth muscle in arterioles demonstrates heterogeneous connexin expression and phosphorylation.
American journal of physiology. Heart and circulatory physiology Jun, 2008 | Pubmed ID: 18408134
Connexins in vascular physiology and pathology.
Antioxidants & redox signaling Feb, 2009 | Pubmed ID: 18834327
Localized expression of an Ins(1,4,5)P3 receptor at the myoendothelial junction selectively regulates heterocellular Ca2+ communication.
Journal of cell science Nov, 2008 | Pubmed ID: 18946029
The myoendothelial junction: breaking through the matrix?
Microcirculation (New York, N.Y. : 1994) May, 2009 | Pubmed ID: 19330678
Oxidized phospholipid species promote in vivo differential cx43 phosphorylation and vascular smooth muscle cell proliferation.
The American journal of pathology Aug, 2009 | Pubmed ID: 19608875
The importance of serine 161 in the sodium channel beta3 subunit for modulation of Na(V)1.2 gating.
Pflugers Archiv : European journal of physiology Sep, 2010 | Pubmed ID: 19806359
Site-specific connexin phosphorylation is associated with reduced heterocellular communication between smooth muscle and endothelium.
Journal of vascular research , 2010 | Pubmed ID: 20016202
Plasminogen activator inhibitor-1 regulates myoendothelial junction formation.
Circulation research Apr, 2010 | Pubmed ID: 20133900
Enhanced connexin 43 expression delays intra-mitotic duration and cell cycle traverse independently of gap junction channel function.
Journal of cellular biochemistry Jun, 2010 | Pubmed ID: 20512937
Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2.
Circulation research Sep, 2010 | Pubmed ID: 20651288
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis.
Nature Oct, 2010 | Pubmed ID: 20944749
Compartmentalized connexin 43 s-nitrosylation/denitrosylation regulates heterocellular communication in the vessel wall.
Arteriosclerosis, thrombosis, and vascular biology Feb, 2011 | Pubmed ID: 21071693
A new method for in vivo visualization of vessel remodeling using a near-infrared dye.
Microcirculation (New York, N.Y. : 1994) Apr, 2011 | Pubmed ID: 21418375
Pannexin1 regulates α1-adrenergic receptor- mediated vasoconstriction.
Circulation research Jun, 2011 | Pubmed ID: 21546608
Spontaneous lung dysfunction and fibrosis in mice lacking connexin 40 and endothelial cell connexin 43.
The American journal of pathology Jun, 2011 | Pubmed ID: 21641379
Characterization of the thoracodorsal artery: morphology and reactivity.
Microcirculation (New York, N.Y. : 1994) May, 2012 | Pubmed ID: 22335567
A novel mRNA binding protein complex promotes localized plasminogen activator inhibitor-1 accumulation at the myoendothelial junction.
Arteriosclerosis, thrombosis, and vascular biology May, 2012 | Pubmed ID: 22383705
Loss of compliance in small arteries, but not in conduit arteries, after 6 weeks exposure to high fat diet.
Journal of cardiovascular translational research Jun, 2012 | Pubmed ID: 22467359
Smooth muscle specific deletion of Ndst1 leads to decreased vessel luminal area and no change in blood pressure in conscious mice.
Journal of cardiovascular translational research Jun, 2012 | Pubmed ID: 22555965
MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation.
Circulation research Jul, 2012 | Pubmed ID: 22652908
Mechanisms of ATP release and signalling in the blood vessel wall.
Cardiovascular research Aug, 2012 | Pubmed ID: 22678409
Expression of pannexin isoforms in the systemic murine arterial network.
Journal of vascular research , 2012 | Pubmed ID: 22739252
Posttranslational modifications in connexins and pannexins.
The Journal of membrane biology Jun, 2012 | Pubmed ID: 22739962
Pannexin 1 in the regulation of vascular tone.
Trends in cardiovascular medicine Apr, 2012 | Pubmed ID: 22841835
S-nitrosylation inhibits pannexin 1 channel function.
The Journal of biological chemistry Nov, 2012 | Pubmed ID: 23033481
Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction.
The Journal of clinical investigation Nov, 2012 | Pubmed ID: 23093775
Endothelial cell expression of haemoglobin α regulates nitric oxide signalling.
Nature Nov, 2012 | Pubmed ID: 23123858
Loss of collectrin, an angiotensin-converting enzyme 2 homolog, uncouples endothelial nitric oxide synthase and causes hypertension and vascular dysfunction.
Circulation Oct, 2013 | Pubmed ID: 24048198
Vascular biomechanical properties in mice with smooth muscle specific deletion of Ndst1.
Molecular and cellular biochemistry Jan, 2014 | Pubmed ID: 24101444
Diverse post-translational modifications of the pannexin family of channel-forming proteins.
Channels (Austin, Tex.) , 2014 | Pubmed ID: 24418849
Secreting von Willebrand factor in a Gα-SNAP.
Blood Jan, 2014 | Pubmed ID: 24434997
Differentiating connexin hemichannels and pannexin channels in cellular ATP release.
FEBS letters Apr, 2014 | Pubmed ID: 24548565
Pannexin-1 as a potentiator of ligand-gated receptor signaling.
Channels (Austin, Tex.) , 2014 | Pubmed ID: 24576994
Connexins, pannexins and innexins: protein cousins with overlapping functions.
FEBS letters Apr, 2014 | Pubmed ID: 24613922
Regulation of cellular communication by signaling microdomains in the blood vessel wall.
Pharmacological reviews , 2014 | Pubmed ID: 24671377
Hemoglobin α in the blood vessel wall.
Free radical biology & medicine Aug, 2014 | Pubmed ID: 24832680
The myoendothelial junction: connections that deliver the message.
Physiology (Bethesda, Md.) Jul, 2014 | Pubmed ID: 24985328
Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction.
Arteriosclerosis, thrombosis, and vascular biology Dec, 2014 | Pubmed ID: 25278292
A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells.
Science signaling Feb, 2015 | Pubmed ID: 25690012
Emerging concepts regarding pannexin 1 in the vasculature.
Biochemical Society transactions Jun, 2015 | Pubmed ID: 26009197
Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation.
Nature communications Aug, 2015 | Pubmed ID: 26242575
The connexin 43/ZO-1 complex regulates cerebral endothelial F-actin architecture and migration.
American journal of physiology. Cell physiology Nov, 2015 | Pubmed ID: 26289751
Endothelial nitric oxide synthase in the microcirculation.
Cellular and molecular life sciences : CMLS Dec, 2015 | Pubmed ID: 26390975
Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes.
Molecular metabolism Sep, 2015 | Pubmed ID: 26413467
CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability.
The Journal of clinical investigation Apr, 2016 | Pubmed ID: 26999610
Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition.
Biochimica et biophysica acta Jul, 2016 | Pubmed ID: 27106139
Small Interfering RNA-Mediated Connexin Gene Knockdown in Vascular Endothelial and Smooth Muscle Cells.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 27207287
Central Role of P2Y6 UDP Receptor in Arteriolar Myogenic Tone.
Arteriosclerosis, thrombosis, and vascular biology Aug, 2016 | Pubmed ID: 27255725
Cardiovascular magnetic resonance detects the progression of impaired myocardial perfusion reserve and increased left-ventricular mass in mice fed a high-fat diet.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance Sep, 2016 | Pubmed ID: 27609091
AXL-Mediated Productive Infection of Human Endothelial Cells by Zika Virus.
Circulation research Nov, 2016 | Pubmed ID: 27650556
Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbαX).
Hypertension (Dallas, Tex. : 1979) Dec, 2016 | Pubmed ID: 27802421
Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia.
Antioxidants & redox signaling May, 2017 | Pubmed ID: 27889956
Pannexin channel and connexin hemichannel expression in vascular function and inflammation.
BMC cell biology Jan, 2017 | Pubmed ID: 28124621
Signaling Pathways Linked to Serotonin-Induced Superoxide Anion Production: A Physiological Role for Mitochondria in Pulmonary Arteries.
Frontiers in physiology , 2017 | Pubmed ID: 28232807
Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions.
American journal of physiology. Heart and circulatory physiology May, 2017 | Pubmed ID: 28283548
The Evolving Role of Diverse Gaseous Transmitters Mediating Heterocellular Communication Within the Vasculature.
Antioxidants & redox signaling Jun, 2017 | Pubmed ID: 28288516
ZP1609/danegaptide and mitochondrial connexin hemichannels: a harbinger for peptide drug design.
British journal of pharmacology Aug, 2017 | Pubmed ID: 28567717
1Department of Molecular Physiology and Biophysics, University of Virginia School of Medicine,
2Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine,
3Department of Hematology, St. Jude Children's Research Hospital,
4Research Histology Core, University of Virginia School of Medicine
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