Department of Chemical Physiology,
Department of Molecular and Experimental Medicine,
Department of Molecular and Cellular Biology,
Department of Molecular Medicine,
Department of Neuroscience
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Organ polarity in Arabidopsis. NOZZLE physically interacts with members of the YABBY family.
Plant physiology Aug, 2004 | Pubmed ID: 15299139
Quenching accumulation of toxic galactose-1-phosphate as a system to select disruption of protein-protein interactions in vivo.
BioTechniques Nov, 2004 | Pubmed ID: 15560141
DNA looping induced by a transcriptional enhancer in vivo.
Nucleic acids research , 2005 | Pubmed ID: 16002789
An antidepressant that extends lifespan in adult Caenorhabditis elegans.
Nature Nov, 2007 | Pubmed ID: 18033297
A high-throughput screen for chemicals that increase the lifespan of Caenorhabditis elegans.
Annals of the New York Academy of Sciences Jul, 2009 | Pubmed ID: 19686215
A pharmacological network for lifespan extension in Caenorhabditis elegans.
Aging cell Apr, 2014 | Pubmed ID: 24134630
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.
Nature Jun, 2014 | Pubmed ID: 24828042
High-throughput small-molecule screening in Caenorhabditis elegans.
Methods in molecular biology (Clifton, N.J.) , 2015 | Pubmed ID: 25618342
Pharmacological classes that extend lifespan of Caenorhabditis elegans.
Frontiers in genetics , 2015 | Pubmed ID: 25784926
Measuring Food Intake and Nutrient Absorption in Caenorhabditis elegans.
Genetics Jun, 2015 | Pubmed ID: 25903497
Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response.
Aging cell Dec, 2015 | Pubmed ID: 26255886
Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality.
eLife Dec, 2015 | Pubmed ID: 26623667
C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension.
Cell reports Mar, 2016 | Pubmed ID: 26923601
Proton Pump Inhibitors Accelerate Endothelial Senescence.
Circulation research Jun, 2016 | Pubmed ID: 27166251
Metabolic drift in the aging brain.
Aging 05, 2016 | Pubmed ID: 27182841
C. elegans as Model for Drug Discovery.
Current topics in medicinal chemistry , 2017 | Pubmed ID: 28137208
The DrugAge database of aging-related drugs.
Aging cell Jun, 2017 | Pubmed ID: 28299908
The mitochondrial ATP synthase is a shared drug target for aging and dementia.
Aging cell Apr, 2018 | Pubmed ID: 29316249
Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms.
eLife Nov, 2018 | Pubmed ID: 30479271
A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia.
Nature communications Dec, 2018 | Pubmed ID: 30532051
Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart.
EMBO reports 04, 2019 | Pubmed ID: 30886000
Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan.
Nature chemical biology 05, 2019 | Pubmed ID: 30911178
Elevating acetyl-CoA levels reduces aspects of brain aging.
eLife Nov, 2019 | Pubmed ID: 31742554
Design and Analysis of Pharmacological Studies in Aging.
Methods in molecular biology (Clifton, N.J.) , 2020 | Pubmed ID: 32410026
The aging transcriptome: read between the lines.
Current opinion in neurobiology Aug, 2020 | Pubmed ID: 32563038
A chemical biology approach to identifying molecular pathways associated with aging.
GeroScience Feb, 2021 | Pubmed ID: 32705410
Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects.
Aging cell Nov, 2020 | Pubmed ID: 33145977
Adipocytes control food intake and weight regain via Vacuolar-type H ATPase.
Nature communications Aug, 2022 | Pubmed ID: 36042358
Targeting Clic1 for the treatment of obesity: A novel therapeutic strategy to reduce food intake and body weight.
Molecular metabolism Oct, 2023 | Pubmed ID: 37604246
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