Ryoichiro Kageyama

The bHLH gene Hes1 is essential for expansion of early T cell precursors.

The bHLH gene hes1 as a repressor of the neuronal commitment of CNS stem cells.

Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system.

The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina.

BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis.

Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear.

Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain.

Dynamic expression and essential functions of Hes7 in somite segmentation.

Math3 and NeuroD regulate amacrine cell fate specification in the retina.

Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop.

Retrovirus-mediated gene transfer to retinal explants.

Candidate markers for stem and early progenitor cells, Musashi-1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine.

Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock.

Oscillations, clocks and segmentation.

The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain.

Retroviral vectors for gene delivery to neural precursor cells.

Defective brain development in mice lacking the Hif-1alpha gene in neural cells.

Fate of neural stem cells grafted into injured inner ears of mice.

Roles of the bHLH gene Hes1 in retinal morphogenesis.

Retinal cell fate determination and bHLH factors.

Identification of a novel basic helix-loop-helix gene, Heslike, and its role in GABAergic neurogenesis.

Overexpression of RFT induces G1-S arrest and apoptosis via p53/p21(Waf1) pathway in glioma cell.

Requirement of multiple basic helix-loop-helix genes for retinal neuronal subtype specification.

Instability of Hes7 protein is crucial for the somite segmentation clock.

Potential for neural regeneration after neurotoxic injury in the adult mammalian retina.

Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation.

Otx2 homeobox gene induces photoreceptor-specific phenotypes in cells derived from adult iris and ciliary tissue.

The role of notch signaling in the development of intrahepatic bile ducts.

Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestine.

Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1.

Roles of bHLH genes in neural stem cell differentiation.

Mash1 and Math3 are required for development of branchiomotor neurons and maintenance of neural progenitors.

Iris-derived cells from adult rodents and primates adopt photoreceptor-specific phenotypes.

Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors.

Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cells.

Hes1 and Hes5 regulate the development of the cranial and spinal nerve systems.

Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells.

Temporal regulation of Cre recombinase activity in neural stem cells.

Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas.

Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system.

The 20th IUBMB International Congress in Kyoto.

Notch1 expression is spatiotemporally correlated with neurogenesis and negatively regulated by Notch1-independent Hes genes in the developing nervous system.

[Biological clock as a conductor for embryogenesis].

High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly.

Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis.

The Hes gene family: repressors and oscillators that orchestrate embryogenesis.

Oscillator mechanism of Notch pathway in the segmentation clock.

Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development.

Regulation of retinal cell fate specification by multiple transcription factors.

Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum.

The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock.

Mash1 is required for neuroendocrine cell development in the glandular stomach.

Oscillations in notch signaling regulate maintenance of neural progenitors.

[Transcription factor network that regulates neural development].

Roles of Hes genes in neural development.

Requirement of multiple lysine residues for the transcriptional activity and the instability of Hes7.

Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline.

Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain.

Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition.

Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways.

Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis.

Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity.

Hopf bifurcation in the presomitic mesoderm during the mouse segmentation.

Continuous neurogenesis in the adult brain.

Rhythmic gene expression in somite formation and neural development.

Dynamic advances in NF-kappaB signaling analysis.

The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells.

Dynamic regulation of Notch signaling in neural progenitor cells.

Spatiotemporal pattern in somitogenesis: a non-Turing scenario with wave propagation.

Practical lessons from theoretical models about the somitogenesis.

Maximizing functional photoreceptor differentiation from adult human retinal stem cells.

Essential roles of Notch signaling in maintenance of neural stem cells in developing and adult brains.

Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling.

Automatic reconstruction of the mouse segmentation network from an experimental evidence database.

Ultradian oscillations in Notch signaling regulate dynamic biological events.

Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development.

Intronic delay is essential for oscillatory expression in the segmentation clock.

Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells.

Continuous neurogenesis in the adult forebrain is required for innate olfactory responses.

The role of Notch signaling in adult neurogenesis.

The role of neurogenesis in olfaction-dependent behaviors.

Genetic methods to identify and manipulate newly born neurons in the adult brain.

Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis.

Dynamic expression of notch signaling genes in neural stem/progenitor cells.

Gene expression profiling of neural stem cells and identification of regulators of neural differentiation during cortical development.

The role of Hes genes in intestinal development, homeostasis and tumor formation.

A multifunctional teal-fluorescent Rosa26 reporter mouse line for Cre- and Flp-mediated recombination.

Light-induced silencing of neural activity in Rosa26 knock-in mice conditionally expressing the microbial halorhodopsin eNpHR2.0.

Mind bomb 1 is required for pancreatic β-cell formation.

In vivo evaluation of ΦC31 recombinase activity in transgenic mice.

Genetic visualization of notch signaling in mammalian neurogenesis.

Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development.

MicroRNA9 regulates neural stem cell differentiation by controlling Hes1 expression dynamics in the developing brain.

Dclk1 distinguishes between tumor and normal stem cells in the intestine.

Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene.

Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling.

Hes1 in the somatic cells of the murine ovary is necessary for oocyte survival and maturation.

Hyperpolarisation-activated cyclic nucleotide-gated channels regulate the spontaneous firing rate of olfactory receptor neurons and affect glomerular formation in mice.

Control of Hes7 expression by Tbx6, the Wnt pathway and the chemical Gsk3 inhibitor LiCl in the mouse segmentation clock.

Retinoid acid specifies neuronal identity through graded expression of Ascl1.

Oscillatory links of Fgf signaling and Hes7 in the segmentation clock.

Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease.

Oscillatory gene expression and somitogenesis.

Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development.

Hedgehog signaling regulates prosensory cell properties during the basal-to-apical wave of hair cell differentiation in the mammalian cochlea.

Oscillatory control of factors determining multipotency and fate in mouse neural progenitors.

bHLH factors in self-renewal, multipotency, and fate choice of neural progenitor cells.

Hes1 oscillations contribute to heterogeneous differentiation responses in embryonic stem cells.

Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning.

Dynamic expression and roles of Hes factors in neural development.

The roles and mechanism of ultradian oscillatory expression of the mouse Hes genes.

The functional significance of newly born neurons integrated into olfactory bulb circuits.

Visualization of Notch signaling oscillation in cells and tissues.

Oscillatory control of bHLH factors in neural progenitors.

Expression dynamics and functions of Hes factors in development and diseases.

Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions.

Impact of Sox9 dosage and Hes1-mediated Notch signaling in controlling the plasticity of adult pancreatic duct cells in mice.

Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2.

Therapeutic targeting of HES1 transcriptional programs in T-ALL.

Deubiquitinating enzymes regulate Hes1 stability and neuronal differentiation.

Disappearance of centroacinar cells in the Notch ligand-deficient pancreas.

Hbp1 regulates the timing of neuronal differentiation during cortical development by controlling cell cycle progression.

In vivo overactivation of the Notch signaling pathway in the developing cochlear epithelium.

Real-time imaging of bHLH transcription factors reveals their dynamic control in the multipotency and fate choice of neural stem cells.

Hes1 and Hes5 are required for differentiation of pituicytes and formation of the neurohypophysis in pituitary development.

The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.

Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis.

Oscillatory control of Delta-like1 in somitogenesis and neurogenesis: A unified model for different oscillatory dynamics.

Making Waves toward the Shore by Synchronicity.

Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information.

Topological defects control collective dynamics in neural progenitor cell cultures.

Hes5 regulates the transition timing of neurogenesis and gliogenesis in mammalian neocortical development.

Segmentation Genes Enter an Excited State.

Illuminating information transfer in signaling dynamics by optogenetics.

ES cell-derived presomitic mesoderm-like tissues for analysis of synchronized oscillations in the segmentation clock.

Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone.

Reconstitution of an Ultradian Oscillator in Mammalian Cells by a Synthetic Biology Approach.

The proneural bHLH genes Mash1, Math3 and NeuroD are required for pituitary development.

Oscillatory Control of Notch Signaling in Development.

Dynamic control of neural stem cells by bHLH factors.

The proneural bHLH genes Mash1, Math3 and NeuroD are required for pituitary development

Multilayered gene control drives timely exit from the stem cell state in uncommitted progenitors during asymmetric neural stem cell division.

Regulation of temporal properties of neural stem cells and transition timing of neurogenesis and gliogenesis during mammalian neocortical development.

Timing and shaping mechanisms of neural development.

Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis.

Notch-Hes signaling in pituitary development.

Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells.

High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain.

Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors.

Bursting the Notch Bubble: New Insights into In Vivo Transcriptional Dynamics.

Regulation of active and quiescent somatic stem cells by Notch signaling.

Generation of a MOR-CreER knock-in mouse line to study cells and neural circuits involved in mu opioid receptor signaling.

Three-dimensional live imaging of Atoh1 reveals the dynamics of hair cell induction and organization in the developing cochlea.

The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension.

Enhanced lysosomal degradation maintains the quiescent state of neural stem cells.