Department of Biochemistry
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Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450.
Chemico-biological interactions Jan, 2002 | Pubmed ID: 11803026
Mechanism of peroxidase-mediated oxidation of carcinogenic o-anisidine and its binding to DNA.
Mutation research Mar, 2002 | Pubmed ID: 11890934
Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy.
Carcinogenesis Apr, 2002 | Pubmed ID: 11960915
New selective inhibitors of cytochromes P450 2B and their application to antimutagenesis of tamoxifen.
Archives of biochemistry and biophysics Jul, 2002 | Pubmed ID: 12061800
DNA adduct formation from quaternary benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine as revealed by the 32P-postlabeling technique.
Chemico-biological interactions Aug, 2002 | Pubmed ID: 12204579
Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes.
Cancer research Oct, 2002 | Pubmed ID: 12384524
Rat microsomes activating the anticancer drug ellipticine to species covalently binding to deoxyguanosine in DNA are a suitable model mimicking ellipticine bioactivation in humans.
Chemical research in toxicology Jan, 2003 | Pubmed ID: 12693029
Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:quinone oxidoreductase.
Carcinogenesis Oct, 2003 | Pubmed ID: 12869422
DNA adduct formation by the anticancer drug ellipticine in rats determined by 32P postlabeling.
International journal of cancer Dec, 2003 | Pubmed ID: 14601046
Identification of a genotoxic mechanism for 2-nitroanisole carcinogenicity and of its carcinogenic potential for humans.
Carcinogenesis May, 2004 | Pubmed ID: 14729594
Enzymes involved in the metabolism of the carcinogen 2-nitroanisole: evidence for its oxidative detoxication by human cytochromes P450.
Chemical research in toxicology May, 2004 | Pubmed ID: 15144223
Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.
International journal of cancer Jan, 2005 | Pubmed ID: 15386410
The anticancer drug ellipticine forms covalent DNA adducts, mediated by human cytochromes P450, through metabolism to 13-hydroxyellipticine and ellipticine N2-oxide.
Cancer research Nov, 2004 | Pubmed ID: 15548707
Expression of cytochrome P450 1A1 and its contribution to oxidation of a potential human carcinogen 1-phenylazo-2-naphthol (Sudan I) in human livers.
Cancer letters Apr, 2005 | Pubmed ID: 15766589
Identification of a genotoxic mechanism for the carcinogenicity of the environmental pollutant and suspected human carcinogen o-anisidine.
International journal of cancer Sep, 2005 | Pubmed ID: 15828049
Structural requirements for inhibitors of cytochromes P450 2B: assessment of the enzyme interaction with diamondoids.
Journal of enzyme inhibition and medicinal chemistry Feb, 2005 | Pubmed ID: 15895681
The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen.
Cancer letters Nov, 2005 | Pubmed ID: 16125300
Molecular mechanism of genotoxicity of the environmental pollutant 3-nitrobenzanthrone.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia Dec, 2005 | Pubmed ID: 16601755
Antitumor drug ellipticine inhibits the activities of rat hepatic cytochromes P450.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia Dec, 2005 | Pubmed ID: 16601806
Carcinogenic pollutants o-nitroanisole and o-anisidine are substrates and inducers of cytochromes P450.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia Dec, 2005 | Pubmed ID: 16601807
Oxidation of an antitumor drug ellipticine by peroxidases.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia Dec, 2005 | Pubmed ID: 16601808
The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and -1A2 and NAD(P)H:quinone oxidoreductase.
Drug metabolism and disposition: the biological fate of chemicals Aug, 2006 | Pubmed ID: 16714372
Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia Jul, 2006 | Pubmed ID: 16936898
Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine.
International journal of cancer Jan, 2007 | Pubmed ID: 17066455
Oxidative detoxication of carcinogenic 2-nitroanisole by human, rat and rabbit cytochrome P450.
Neuro endocrinology letters Dec, 2006 | Pubmed ID: 17159769
Toxicological aspects of flavonoid interaction with biomacromolecules.
Neuro endocrinology letters Dec, 2006 | Pubmed ID: 17159770
Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes.
Neuro endocrinology letters Dec, 2006 | Pubmed ID: 17159771
Modulation of CYP1A1-mediated oxidation of carcinogenic azo dye Sudan I and its binding to DNA by cytochrome b5.
Neuro endocrinology letters Dec, 2006 | Pubmed ID: 17159775
DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells.
Cancer letters Jul, 2007 | Pubmed ID: 17306925
Formation and persistence of DNA adducts of anticancer drug ellipticine in rats.
Toxicology Jul, 2007 | Pubmed ID: 17482743
The anticancer drug ellipticine is a potent inducer of rat cytochromes P450 1A1 and 1A2, thereby modulating its own metabolism.
Drug metabolism and disposition: the biological fate of chemicals Oct, 2007 | Pubmed ID: 17656468
Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy.
Mutation research Jan-Feb, 2008 | Pubmed ID: 17851120
Mapping of cytochrome P450 2B4 substrate binding sites by photolabile probe 3-azidiamantane: identification of putative substrate access regions.
Archives of biochemistry and biophysics Dec, 2007 | Pubmed ID: 17961497
Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse.
Toxicology and applied pharmacology Feb, 2008 | Pubmed ID: 17976674
The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity.
Toxicology May, 2008 | Pubmed ID: 18329153
Redox cycling in the metabolism of the environmental pollutant and suspected human carcinogen o-anisidine by rat and rabbit hepatic microsomes.
Chemical research in toxicology Aug, 2008 | Pubmed ID: 18624415
Macleaya cordata extract and Sangrovit genotoxicity. Assessment in vivo.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia Jun, 2008 | Pubmed ID: 18795072
Structural analysis of binding of a diamantoid substrate to cytochrome P450 2B4: possible role of Arg 133 in modulation of function and activity of this enzyme.
Neuro endocrinology letters Oct, 2008 | Pubmed ID: 18987581
Isolation and partial characterization of the adduct formed by 13-hydroxyellipticine with deoxyguanosine in DNA.
Neuro endocrinology letters Oct, 2008 | Pubmed ID: 18987592
Induction of cytochromes P450 in small intestine by chemopreventive compounds.
Neuro endocrinology letters Oct, 2008 | Pubmed ID: 18987596
Human cytochromes P450 1A1 and 1A2 participate in detoxication of carcinogenic aristolochic acid.
Neuro endocrinology letters Oct, 2008 | Pubmed ID: 18987598
A one-electron oxidation of carcinogenic nonaminoazo dye Sudan I by horseradish peroxidase.
Neuro endocrinology letters Oct, 2008 | Pubmed ID: 18987613
Preparation of a biologically active apo-cytochrome b5 via heterologous expression in Escherichia coli.
Protein expression and purification Aug, 2009 | Pubmed ID: 19358889
The role of biotransformation enzymes in the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions and difficult answers.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia Mar, 2009 | Pubmed ID: 19365519
3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone, induces biotransformation enzymes in rat kidney and lung.
Mutation research May, 2009 | Pubmed ID: 19398038
The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells.
Biochemical pharmacology May, 2009 | Pubmed ID: 19426684
Rat cytochromes P450 oxidize 2-nitrophenol, a human metabolite of carcinogenic 2-nitroanisole.
Neuro endocrinology letters , 2009 | Pubmed ID: 20027144
Oxidation of 3-aminobenzanthrone, a human metabolite of carcinogenic environmental pollutant 3-nitrobenzanthrone, by cytochromes P450 - similarity between human and rat enzymes.
Neuro endocrinology letters , 2009 | Pubmed ID: 20027145
Cytotoxicity of and DNA adduct formation by ellipticine in human U87MG glioblastoma cancer cells.
Neuro endocrinology letters , 2009 | Pubmed ID: 20027146
Modulation of cytochrome P450 enzyme system by selected flavonoids.
Neuro endocrinology letters , 2009 | Pubmed ID: 20027147
Preparation of apo-cytochrome b5 utilizing heme transfer to apo-myoglobin.
Neuro endocrinology letters , 2009 | Pubmed ID: 20027148
Isolation and partial characterization of catechol 1,2-dioxygenase of phenol degrading yeast Candida tropicalis.
Neuro endocrinology letters , 2009 | Pubmed ID: 20027149
Mechanisms of the different DNA adduct forming potentials of the urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone.
Chemical research in toxicology Jul, 2010 | Pubmed ID: 20545351
The binding affinity of carcinogenic N-nitrosodimethylamine and N-nitrosomethylaniline to cytochromes P450 2B4, 2E1 and 3A6 does not dictate the rate of their enzymatic N-demethylation.
General physiology and biophysics Jun, 2010 | Pubmed ID: 20577029
Glycosylation protects proteins against free radicals generated from toxic xenobiotics.
Toxicological sciences : an official journal of the Society of Toxicology Oct, 2010 | Pubmed ID: 20616208
Induction of biotransformation enzymes by the carcinogenic air-pollutant 3-nitrobenzanthrone in liver, kidney and lung, after intra-tracheal instillation in rats.
Mutation research Feb, 2011 | Pubmed ID: 21167309
Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney.
Neuro endocrinology letters , 2010 | Pubmed ID: 21187821
Identification of rat cytochromes P450 metabolizing N-(2-methoxyphenyl)hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole.
Neuro endocrinology letters , 2010 | Pubmed ID: 21187827
Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA.
Interdisciplinary toxicology Mar, 2009 | Pubmed ID: 21217841
Oxidation of the carcinogenic non-aminoazo dye 1-phenylazo-2-hydroxy-naphthalene (Sudan I) by cytochromes P450 and peroxidases: a comparative study.
Interdisciplinary toxicology Sep, 2009 | Pubmed ID: 21217854
The effects of selected flavonoids on cytochromes P450 in rat liver and small intestine.
Interdisciplinary toxicology Sep, 2009 | Pubmed ID: 21217855
Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells.
Interdisciplinary toxicology Sep, 2009 | Pubmed ID: 21217856
Analysis of benzo[a]pyrene metabolites formed by rat hepatic microsomes using high pressure liquid chromatography: optimization of the method.
Interdisciplinary toxicology Dec, 2009 | Pubmed ID: 21217860
DNA and histone deacetylases as targets for neuroblastoma treatment.
Interdisciplinary toxicology Jun, 2010 | Pubmed ID: 21217872
Contribution of biotransformation enzymes to the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions, difficult answers.
Interdisciplinary toxicology Jun, 2008 | Pubmed ID: 21218097
Rat cytochromes P450 oxidize 3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone.
Interdisciplinary toxicology Sep, 2008 | Pubmed ID: 21218105
Experimental approaches to evaluate activities of cytochromes P450 3A.
Interdisciplinary toxicology Sep, 2008 | Pubmed ID: 21218106
Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2.
Interdisciplinary toxicology Sep, 2008 | Pubmed ID: 21218107
Oxidation of carcinogenic 2-nitroanisole by rat cytochromes P450 - similarity between human and rat enzymes.
Interdisciplinary toxicology Sep, 2008 | Pubmed ID: 21218109
The comparison of cytotoxicity of the anticancer drugs doxorubicin and ellipticine to human neuroblastoma cells.
Interdisciplinary toxicology Sep, 2008 | Pubmed ID: 21218110
Optimalization of preparation of apo-cytochrome b(5) utilizing apo-myoglobin.
Interdisciplinary toxicology Sep, 2008 | Pubmed ID: 21218111
Cytochrome P450-mediated metabolism of N-(2-methoxyphenyl)-hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole.
Interdisciplinary toxicology Dec, 2008 | Pubmed ID: 21218119
Isolation of cytoplasmic NADPH-dependent phenol hydroxylase and catechol-1,2-dioxygenase from Candida tropicalis yeast.
Interdisciplinary toxicology Dec, 2008 | Pubmed ID: 21218120
Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.
Toxicological sciences : an official journal of the Society of Toxicology May, 2011 | Pubmed ID: 21362632
The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases.
Environmental and molecular mutagenesis Jul, 2011 | Pubmed ID: 21370283
Cytochrome b(5) shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy.
Biochemical pharmacology Sep, 2011 | Pubmed ID: 21683692
Ellipticine cytotoxicity to cancer cell lines - a comparative study.
Interdisciplinary toxicology Jun, 2011 | Pubmed ID: 21753906
Human cytochrome-P450 enzymes metabolize N-(2-methoxyphenyl)hydroxylamine, a metabolite of the carcinogens o-anisidine and o-nitroanisole, thereby dictating its genotoxicity.
Mutation research Dec, 2011 | Pubmed ID: 21946300
Mechanisms of ellipticine-mediated resistance in UKF-NB-4 neuroblastoma cells.
Cancer science Feb, 2012 | Pubmed ID: 22040216
Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.
Toxicological sciences : an official journal of the Society of Toxicology Feb, 2012 | Pubmed ID: 22086975
Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma.
Neuro endocrinology letters , 2011 | Pubmed ID: 22167207
Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases.
Neuro endocrinology letters , 2011 | Pubmed ID: 22167209
Impact of beta-naphthoflavone on genotoxicity of food-derived carcinogens.
Neuro endocrinology letters , 2011 | Pubmed ID: 22167217
Isolation and partial characterization of extracellular NADPH-dependent phenol hydroxylase oxidizing phenol to catechol in Comamonas testosteroni.
Neuro endocrinology letters , 2011 | Pubmed ID: 22167219
Role of cytochromes P450 in metabolism of carcinogenic aristolochic acid I: evidence of their contribution to aristolochic acid I detoxication and activation in rat liver.
Neuro endocrinology letters , 2011 | Pubmed ID: 22167220
Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O-acetyltransferases.
Chemical research in toxicology May, 2012 | Pubmed ID: 22390216
Formation, persistence, and identification of DNA adducts formed by the carcinogenic environmental pollutant o-anisidine in rats.
Toxicological sciences : an official journal of the Society of Toxicology Jun, 2012 | Pubmed ID: 22403159
Analysis of covalent ellipticine- and doxorubicin-derived adducts in DNA of neuroblastoma cells by the ³²P-postlabeling technique.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia Jun, 2012 | Pubmed ID: 22837132
Ellipticine oxidation and DNA adduct formation in human hepatocytes is catalyzed by human cytochromes P450 and enhanced by cytochrome b5.
Toxicology Dec, 2012 | Pubmed ID: 22917556
NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I.
Toxicology and applied pharmacology Dec, 2012 | Pubmed ID: 22982977
Modern micro and nanoparticle-based imaging techniques.
Sensors (Basel, Switzerland) Nov, 2012 | Pubmed ID: 23202187
Induced expression of cytochrome P450 1A and NAD(P)H:quinone oxidoreductase determined at mRNA, protein, and enzyme activity levels in rats exposed to the carcinogenic azo dye 1-phenylazo-2-naphthol (Sudan I).
Chemical research in toxicology Feb, 2013 | Pubmed ID: 23289503
Activation and detoxification metabolism of urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone by rat and mouse hepatic microsomes.
Neuro endocrinology letters , 2012 | Pubmed ID: 23353838
Impact of histone deacetylase inhibitor valproic acid on the anticancer effect of etoposide on neuroblastoma cells.
Neuro endocrinology letters , 2012 | Pubmed ID: 23353839
Theoretical investigation of differences in nitroreduction of aristolochic acid I by cytochromes P450 1A1, 1A2 and 1B1.
Neuro endocrinology letters , 2012 | Pubmed ID: 23353840
Effects of cytochrome P450 inhibitors on peroxidase activity.
Neuro endocrinology letters , 2012 | Pubmed ID: 23353841
The role of metallothionein in oxidative stress.
International journal of molecular sciences Mar, 2013 | Pubmed ID: 23502468
Enzymes metabolizing aristolochic acid and their contribution to the development of aristolochic acid nephropathy and urothelial cancer.
Current drug metabolism Jul, 2013 | Pubmed ID: 23701164
Apoferritin modified magnetic particles as doxorubicin carriers for anticancer drug delivery.
International journal of molecular sciences Jun, 2013 | Pubmed ID: 23807501
Sarcosine as a potential prostate cancer biomarker--a review.
International journal of molecular sciences Jul, 2013 | Pubmed ID: 23880848
Ellipticines as DNA-targeted chemotherapeutics.
Current medicinal chemistry , 2014 | Pubmed ID: 24059226
The relationship between DNA adduct formation by benzo[a]pyrene and expression of its activation enzyme cytochrome P450 1A1 in rat.
Environmental toxicology and pharmacology Nov, 2013 | Pubmed ID: 24095716
Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid.
Xenobiotica; the fate of foreign compounds in biological systems Jan, 2014 | Pubmed ID: 24152141
A novel insight into the cardiotoxicity of antineoplastic drug doxorubicin.
International journal of molecular sciences Oct, 2013 | Pubmed ID: 24185911
Histone deacetylase inhibitors in cancer therapy. A review.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia Jun, 2014 | Pubmed ID: 24263215
The effect of benzo[a]pyrene on metabolic activation of anticancer drug ellipticine in mice.
Neuro endocrinology letters , 2013 | Pubmed ID: 24362092
Oxidation of carcinogenic benzo[a]pyrene by human and rat cytochrome P450 1A1 and its influencing by cytochrome b5 - a comparative study.
Neuro endocrinology letters , 2013 | Pubmed ID: 24362093
Alcoholic liver cirrhosis increases the risk of left ventricular diastolic dysfunction.
Neuro endocrinology letters , 2013 | Pubmed ID: 24362094
Cisplatin-resistant prostate cancer model: Differences in antioxidant system, apoptosis and cell cycle.
International journal of oncology Mar, 2014 | Pubmed ID: 24366574
Hypoxia-mediated histone acetylation and expression of N-myc transcription factor dictate aggressiveness of neuroblastoma cells.
Oncology reports Apr, 2014 | Pubmed ID: 24481548
Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions.
Toxicology Apr, 2014 | Pubmed ID: 24530354
The influence of dicoumarol on the bioactivation of the carcinogen aristolochic acid I in rats.
Mutagenesis May, 2014 | Pubmed ID: 24598128
The effect of aristolochic acid I on expression of NAD(P)H:quinone oxidoreductase in mice and rats--a comparative study.
Mutation research. Genetic toxicology and environmental mutagenesis Jul, 2014 | Pubmed ID: 24769487
The application of an emerging technique for protein-protein interaction interface mapping: the combination of photo-initiated cross-linking protein nanoprobes with mass spectrometry.
International journal of molecular sciences May, 2014 | Pubmed ID: 24865487
Mechanisms of enzyme-catalyzed reduction of two carcinogenic nitro-aromatics, 3-nitrobenzanthrone and aristolochic acid I: Experimental and theoretical approaches.
International journal of molecular sciences Jun, 2014 | Pubmed ID: 24918288
Introduction of water into the heme distal side by Leu65 mutations of an oxygen sensor, YddV, generates verdoheme and carbon monoxide, exerting the heme oxygenase reaction.
Journal of inorganic biochemistry Nov, 2014 | Pubmed ID: 25046385
The influence of ochratoxin A on DNA adduct formation by the carcinogen aristolochic acid in rats.
Archives of toxicology Nov, 2015 | Pubmed ID: 25209566
Flexible docking-based molecular dynamics/steered molecular dynamics calculations of protein-protein contacts in a complex of cytochrome P450 1A2 with cytochrome b5.
Biochemistry Oct, 2014 | Pubmed ID: 25313797
Role of rat cytochromes P450 in the oxidation of 17α-ethinylestradiol.
Environmental toxicology and pharmacology Nov, 2014 | Pubmed ID: 25461545
Formation of DNA adducts by ellipticine and its micellar form in rats - a comparative study.
Sensors (Basel, Switzerland) Dec, 2014 | Pubmed ID: 25479328
Modulation of induced cytotoxicity of doxorubicin by using apoferritin and liposomal cages.
International journal of molecular sciences Dec, 2014 | Pubmed ID: 25514405
The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN™) mice and pure enzymes.
International journal of molecular sciences Dec, 2014 | Pubmed ID: 25547492
Fluorescent cellular assay for screening agents inhibiting Pseudomonas aeruginosa adherence.
Sensors (Basel, Switzerland) Jan, 2015 | Pubmed ID: 25602268
Enzymes oxidizing the azo dye 1-phenylazo-2-naphthol (Sudan I) and their contribution to its genotoxicity and carcinogenicity.
Current drug metabolism , 2014 | Pubmed ID: 25658126
Doxorubicin interactions with bovine serum albumin revealed by microdialysis with on-line laser-induced fluorescence detection at subpicogram level.
Electrophoresis Jun, 2015 | Pubmed ID: 25808901
Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene.
Toxicological sciences : an official journal of the Society of Toxicology Aug, 2015 | Pubmed ID: 25911668
The synergistic effects of DNA-damaging drugs cisplatin and etoposide with a histone deacetylase inhibitor valproate in high-risk neuroblastoma cells.
International journal of oncology Jul, 2015 | Pubmed ID: 25963435
The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice.
Archives of toxicology Apr, 2016 | Pubmed ID: 25995008
Vacuolar-ATPase-mediated intracellular sequestration of ellipticine contributes to drug resistance in neuroblastoma cells.
International journal of oncology Sep, 2015 | Pubmed ID: 26134421
Photo-initiated crosslinking extends mapping of the protein-protein interface to membrane-embedded portions of cytochromes P450 2B4 and b₅.
Methods (San Diego, Calif.) Nov, 2015 | Pubmed ID: 26235815
A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches.
International journal of molecular sciences Nov, 2015 | Pubmed ID: 26593908
A study on 17alpha-ethinylestradiol metabolism in rat and Pleurotus ostreatus.
Neuro endocrinology letters , 2015 | Pubmed ID: 26757108
Cytotoxicity of and DNA adduct formation by ellipticine and its micellar form in human leukemia cells in vitro.
Neuro endocrinology letters , 2015 | Pubmed ID: 26757112
Ferrous and ferric state of cytochromes P450 in intact Escherichia coli cells: a possible role of cytochrome P450-flavodoxin interactions.
Neuro endocrinology letters , 2015 | Pubmed ID: 26757119
Preparation and application of anti-peptide antibodies for detection of orphan cytochromes P450.
Neuro endocrinology letters , 2015 | Pubmed ID: 26757124
Role of dihydromyricetin in cytochrome P450-mediated metabolism and carcinogen activation.
Neuro endocrinology letters , 2015 | Pubmed ID: 26757127
The effects of heavy metal ions, phthalates and ochratoxin A on oxidation of carcinogenic aristolochic acid I causing Balkan endemic nephropathy.
Neuro endocrinology letters , 2015 | Pubmed ID: 26757129
Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo.
Toxicology Feb, 2016 | Pubmed ID: 26845733
Relation of exposure to amino acids involved in sarcosine metabolic pathway on behavior of non-tumor and malignant prostatic cell lines.
The Prostate May, 2016 | Pubmed ID: 26847870
Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.
International journal of molecular sciences Feb, 2016 | Pubmed ID: 26861298
Electrochemical sensing of etoposide using carbon quantum dot modified glassy carbon electrode.
The Analyst Apr, 2016 | Pubmed ID: 26882954
The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[a]pyrene in human livers.
Environmental and molecular mutagenesis Apr, 2016 | Pubmed ID: 26919089
Fluorescence Characterization of Gold Modified Liposomes with Antisense N-myc DNA Bound to the Magnetisable Particles with Encapsulated Anticancer Drugs (Doxorubicin, Ellipticine and Etoposide).
Sensors (Basel, Switzerland) Feb, 2016 | Pubmed ID: 26927112
NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1.
Monatshefte fur chemie , 2016 | Pubmed ID: 27110038
Heterologous expression of human cytochrome P450 2S1 inand investigation of its role in metabolism of benzo[]pyrene and ellipticine.
Monatshefte fur chemie , 2016 | Pubmed ID: 27110039
Induced expression of microsomal cytochrome b5 determined at mRNA and protein levels in rats exposed to ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I).
Monatshefte fur chemie , 2016 | Pubmed ID: 27110040
Site-Directed Conjugation of Antibodies to Apoferritin Nanocarrier for Targeted Drug Delivery to Prostate Cancer Cells.
ACS applied materials & interfaces Jun, 2016 | Pubmed ID: 27219717
NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.
Chemical research in toxicology 08, 2016 | Pubmed ID: 27404282
Balkan endemic nephropathy: an update on its aetiology.
Archives of toxicology Nov, 2016 | Pubmed ID: 27538407
Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone.
Archives of toxicology Apr, 2017 | Pubmed ID: 27557898
Correction to NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.
Chemical research in toxicology Sep, 2016 | Pubmed ID: 27575721
Zinc and zinc-containing biomolecules in childhood brain tumors.
Journal of molecular medicine (Berlin, Germany) Nov, 2016 | Pubmed ID: 27638340
Prostate tumor attenuation in the nu/nu murine model due to anti-sarcosine antibodies in folate-targeted liposomes.
Scientific reports Sep, 2016 | Pubmed ID: 27646588
Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer.
PloS one , 2016 | Pubmed ID: 27824899
Fully automated two-step assay for detection of metallothionein through magnetic isolation using functionalized γ-Fe2O3 particles.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Dec, 2016 | Pubmed ID: 27825623
Exposure of rats to exogenous endocrine disruptors 17alpha-ethinylestradiol and benzo(a)pyrene and an estrogenic hormone estradiol induces expression of cytochromes P450 involved in their metabolism.
Neuro endocrinology letters Dec, 2016 | Pubmed ID: 28263535
Effectiveness of human cytochrome P450 3A4 present in liposomal and microsomal nanoparticles in formation of covalent DNA adducts by ellipticine.
Neuro endocrinology letters Dec, 2016 | Pubmed ID: 28263536
Apoferritin as an ubiquitous nanocarrier with excellent shelf life.
International journal of nanomedicine , 2017 | Pubmed ID: 28392686
The capacity and effectiveness of diosmectite and charcoal in trapping the compounds causing the most frequent intoxications in acute medicine: A comparative study.
Environmental toxicology and pharmacology Jun, 2017 | Pubmed ID: 28445845
Histone Deacetylase Inhibitors as Anticancer Drugs.
International journal of molecular sciences Jul, 2017 | Pubmed ID: 28671573
Utilizing of Square Wave Voltammetry to Detect Flavonoids in the Presence of Human Urine.
Sensors (Basel, Switzerland) Oct, 2007 | Pubmed ID: 28903234
VPA does not enhance platinum binding to DNA in cisplatin-resistant neuroblastoma cancer cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine Sep, 2017 | Pubmed ID: 28945187
DNA interaction with platinum-based cytostatics revealed by DNA sequencing.
Analytical biochemistry Sep, 2017 | Pubmed ID: 28970072
An insight into the complex roles of metallothioneins in malignant diseases with emphasis on (sub)isoforms/isoforms and epigenetics phenomena.
Pharmacology & therapeutics Oct, 2017 | Pubmed ID: 28987322
DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial Cancer.
International journal of molecular sciences Oct, 2017 | Pubmed ID: 29036902
Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[]pyrene in prokaryotic and eukaryotic expression systems.
Monatshefte fur chemie , 2017 | Pubmed ID: 29104317
Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches.
Monatshefte fur chemie , 2017 | Pubmed ID: 29104318
Cytochromeplays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine.
Monatshefte fur chemie , 2017 | Pubmed ID: 29104319
Sarcosine influences apoptosis and growth of prostate cells via cell-type specific regulation of distinct sets of genes.
The Prostate Feb, 2018 | Pubmed ID: 29105933
The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells.
International journal of molecular sciences Jan, 2018 | Pubmed ID: 29304031
Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of "luminal" muscle-invasive bladder cancers.
Molecular carcinogenesis Jan, 2018 | Pubmed ID: 29323757
Cytochrome bimpacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b/P450 reductase null (HBRN) mice.
Archives of toxicology Jan, 2018 | Pubmed ID: 29368147
Comparative gene expression profiling of human metallothionein-3 up-regulation in neuroblastoma cells and its impact on susceptibility to cisplatin.
Oncotarget Jan, 2018 | Pubmed ID: 29435113
The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells.
Toxicology Feb, 2018 | Pubmed ID: 29471073
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