Department of Immunology,
Genetics and Pathology,
Science for Life Laboratory,
Department of Immunology, Genetics and Pathology, Science for Life Laboratory
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Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen.
Blood Nov, 2009 | Pubmed ID: 19713457
IGHV3-21 gene frequency in a Swedish cohort of patients with newly diagnosed chronic lymphocytic leukemia.
Clinical lymphoma, myeloma & leukemia Jun, 2012 | Pubmed ID: 22464020
Next generation RNA-sequencing in prognostic subsets of chronic lymphocytic leukemia.
American journal of hematology Jul, 2012 | Pubmed ID: 22674506
Temporal dynamics of clonal evolution in chronic lymphocytic leukemia with stereotyped IGHV4-34/IGKV2-30 antigen receptors: longitudinal immunogenetic evidence.
Molecular medicine (Cambridge, Mass.) Aug, 2013 | Pubmed ID: 23922244
Antigen selection in B-cell lymphomas--tracing the evidence.
Seminars in cancer biology Dec, 2013 | Pubmed ID: 23932942
A key role for EZH2 in epigenetic silencing of HOX genes in mantle cell lymphoma.
Epigenetics Dec, 2013 | Pubmed ID: 24107828
In situ Protein Detection for Companion Diagnostics.
Frontiers in oncology Oct, 2013 | Pubmed ID: 24199171
IgG-switched CLL has a distinct immunogenetic signature from the common MD variant: ontogenetic implications.
Clinical cancer research : an official journal of the American Association for Cancer Research Jan, 2014 | Pubmed ID: 24240110
Lymphoma development in patients with autoimmune and inflammatory disorders--what are the driving forces?
Seminars in cancer biology Feb, 2014 | Pubmed ID: 24333759
Immunogenetic studies of chronic lymphocytic leukemia: revelations and speculations about ontogeny and clinical evolution.
Cancer research Aug, 2014 | Pubmed ID: 25074616
Clonal evolution in chronic lymphocytic leukemia: impact of subclonality on disease progression.
Expert review of hematology Feb, 2015 | Pubmed ID: 25345442
Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting.
Haematologica Mar, 2015 | Pubmed ID: 25480502
An entity evolving into a community: defining the common ancestor and evolutionary trajectory of chronic lymphocytic leukemia stereotyped subset #4.
Molecular medicine (Cambridge, Mass.) Apr, 2015 | Pubmed ID: 25486132
Deciphering the molecular landscape in chronic lymphocytic leukemia: time frame of disease evolution.
Haematologica Jan, 2015 | Pubmed ID: 25552678
Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations.
Blood Jan, 2015 | Pubmed ID: 25634617
Molecular evidence for antigen drive in the natural history of mantle cell lymphoma.
The American journal of pathology Jun, 2015 | Pubmed ID: 25843681
The complex interplay between cell-intrinsic and cell-extrinsic factors driving the evolution of chronic lymphocytic leukemia.
Seminars in cancer biology Oct, 2015 | Pubmed ID: 25963298
Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia.
The Journal of experimental medicine Jun, 2015 | Pubmed ID: 25987724
ARResT/AssignSubsets: a novel application for robust subclassification of chronic lymphocytic leukemia based on B cell receptor IG stereotypy.
Bioinformatics (Oxford, England) Dec, 2015 | Pubmed ID: 26249808
Prognostic relevance of MYD88 mutations in CLL: the jury is still out.
Blood Aug, 2015 | Pubmed ID: 26294719
Antigen Selection Shapes the T-cell Repertoire in Chronic Lymphocytic Leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research Jan, 2016 | Pubmed ID: 26338994
UGT2B17 expression: a novel prognostic marker within IGHV-mutated chronic lymphocytic leukemia?
Haematologica Feb, 2016 | Pubmed ID: 26589911
An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors.
Clinical cancer research : an official journal of the American Association for Cancer Research Apr, 2016 | Pubmed ID: 26647217
Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations.
Blood Feb, 2016 | Pubmed ID: 26675346
Innovation in the prognostication of chronic lymphocytic leukemia: how far beyond TP53 gene analysis can we go?
Haematologica Mar, 2016 | Pubmed ID: 26928246
Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study.
The Lancet. Haematology Nov, 2014 | Pubmed ID: 27030157
Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference.
Haematologica 07, 2016 | Pubmed ID: 27102498
Not all subclones matter in CLL.
Blood 04, 2016 | Pubmed ID: 27127300
The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia.
Oncotarget Jun, 2016 | Pubmed ID: 27191993
Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors.
Haematologica 08, 2016 | Pubmed ID: 27198719
ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres.
Haematologica 09, 2016 | Pubmed ID: 27479817
Massive and parallel expression profiling using microarrayed single-cell sequencing.
Nature communications 10, 2016 | Pubmed ID: 27739429
Numerous Ontogenetic Roads to Mantle Cell Lymphoma: Immunogenetic and Immunohistochemical Evidence.
The American journal of pathology Jul, 2017 | Pubmed ID: 28457696
Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes.
Clinical cancer research : an official journal of the American Association for Cancer Research Sep, 2017 | Pubmed ID: 28536306
Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratification.
Haematologica 06, 2017 | Pubmed ID: 28566340
No improvement in long-term survival over time for chronic lymphocytic leukemia patients in stereotyped subsets #1 and #2 treated with chemo(immuno)therapy.
Haematologica Apr, 2018 | Pubmed ID: 29269523
Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations.
Haematologica May, 2018 | Pubmed ID: 29449433
Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia.
Haematologica Sep, 2018 | Pubmed ID: 30262567
Automated shape-based clustering of 3D immunoglobulin protein structures in chronic lymphocytic leukemia.
BMC bioinformatics Nov, 2018 | Pubmed ID: 30453883
Andreas Agathangelidis*,1,
Lesley Ann Sutton*,2,3,
Anastasia Hadzidimitriou1,
Cristina Tresoldi4,
Anton W. Langerak5,
Chrysoula Belessi6,
Frederic Davi7,
Richard Rosenquist2,3,
Kostas Stamatopoulos1,2,
Paolo Ghia8
1Institute of Applied Biosciences, Centre for Research and Technology Hellas,
2Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University,
3Department of Molecular Medicine and Surgery, Karolinska Institutet,
4Division of Immunology, Transplantation and Infectious, IRCCS San Raffaele Scientific Institute,
5Department of Immunology, Laboratory for Medical Immunology, Erasmus University Medical Center,
6Hematology Department, Nikea General Hospital,
7, Assistance publique - Hôpitaux de Paris (AP-HP), Hopital Pitié-Salpêtrière, Department of Hematology, and UPMC University Paris 06, UMRS 1138,
8Division of Experimental Oncology, IRCCS Istituto Scientifico San Raffaele and Università Vita-Salute San Raffaele
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