Department of Neurology
Sonja Hochmeister is an Associate Professor of Neurology at Medical University Graz, Austria, Dept. of Neurology. She is working in the field of neuroimmunology, animal models and histopathology since 2001. After graduating from medical school in Vienna, Austria in 2001, she studied molecular biology and did her PhD thesis from 2003-2006 at the Center for Brain Research, Dept. Neuroimmunology in Vienna (Head and PhD supervisor Prof. Hans Lassmann). Her PhD study focused on mechanisms of brain inflammation and blood brain barrier disturbance. In 2006 she switched to Medical University Graz, Austria and started a further training in clinical neurology, ending with the board certification in Neurology in 2012 and the postdoctoral lecture qualification in 2013. During this training and thereafter she pursued her research career with a focus on histopathology and animal models. Research time spent abroad at Charite Berlin/ Germany and Karolinska Institute in Stockholm/ Sweden helped to intensify the insights and knowledge on animal models. The current main research interest is firstly to provide a reliable animal model mimicking features typical for progressive Multiple Sclerosis (MS) and secondly to use this model to elucidate the mechanisms behind the often seen cognitive decline of late stage MS patients. Testing out compounds believed to be neuroprotective and/or enhance repair processes in this cortical demyelination model is a further long-term aim of her work.
Re-expression of N-cadherin in remyelinating lesions of experimental inflammatory demyelination.
Experimental neurology Sep, 2012 | Pubmed ID: 22735489
Intrastriatal injection of interleukin-1 beta triggers the formation of neuromyelitis optica-like lesions in NMO-IgG seropositive rats.
Acta neuropathologica communications May, 2013 | Pubmed ID: 24252536
Maternal neurofascin-specific autoantibodies bind to structures of the fetal nervous system during pregnancy, but have no long term effect on development in the rat.
PloS one , 2014 | Pubmed ID: 24465550
Highly encephalitogenic aquaporin 4-specific T cells and NMO-IgG jointly orchestrate lesion location and tissue damage in the CNS.
Acta neuropathologica Dec, 2015 | Pubmed ID: 26530185
Widespread cortical demyelination of both hemispheres can be induced by injection of pro-inflammatory cytokines via an implanted catheter in the cortex of MOG-immunized rats.
Experimental neurology 08, 2017 | Pubmed ID: 28457906
The pathology of central nervous system inflammatory demyelinating disease accompanying myelin oligodendrocyte glycoprotein autoantibody.
Acta neuropathologica 05, 2020 | Pubmed ID: 32048003
A Fulminant Case of Demyelinating Encephalitis With Extensive Cortical Involvement Associated With Anti-MOG Antibodies.
Frontiers in neurology , 2020 | Pubmed ID: 32117004
Anti-CD20 treatment effectively attenuates cortical pathology in a rat model of widespread cortical demyelination.
Journal of neuroinflammation Jun, 2021 | Pubmed ID: 34130726
Muammer Üçal*,1,
Michaela Tanja Haindl*,2,
Milena Z. Adzemovic3,
Manuel Zeitelhofer4,
Ute Schaefer1,
Franz Fazekas2,
Sonja Hochmeister2
1Research Unit of Experimental Neurotraumatology, Department of Neurosurgery, Medical University Graz,
2Department of Neurology, Medical University Graz,
3Centre for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institutet,
4Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
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