Shigeyoshi Itohara

Dynamic characteristics and adaptability of mouse vestibulo-ocular and optokinetic response eye movements and the role of the flocculo-olivary system revealed by chemical lesions.

Inhibition of nitric oxide synthesis and gene knockout of neuronal nitric oxide synthase impaired adaptation of mouse optokinetic response eye movements.

Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex.

Embryonic lethality of molecular chaperone hsp47 knockout mice is associated with defects in collagen biosynthesis.

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis.

Complementary expression and neurite outgrowth activity of netrin-G subfamily members.

Transgenic mice expressing a pH and Cl- sensing yellow-fluorescent protein under the control of a potassium channel promoter.

Normal development of serotonergic neurons in mice lacking S100B.

Glial protein S100B modulates long-term neuronal synaptic plasticity.

Distribution of phosphorylated glial fibrillary acidic protein in the mouse central nervous system.

Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice.

Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice.

In vivo glioma growth requires host-derived matrix metalloproteinase 2 for maintenance of angioarchitecture.

Lesion-induced thalamocortical axonal plasticity in the S1 cortex is independent of NMDA receptor function in excitatory cortical neurons.

NMDA receptor-dependent pattern transfer from afferents to postsynaptic cells and dendritic differentiation in the barrel cortex.

Postnatal expression of Cdkl2 in mouse brain revealed by LacZ inserted into the Cdkl2 locus.

Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality.

The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model.

Stimulus-induced behavior in F1 hybrids of seizure-sensitive and seizure-resistant gerbils.

Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice.

BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice.

Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.

Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model.

Laminar organization of the developing lateral olfactory tract revealed by differential expression of cell recognition molecules.

Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice.

Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors.

A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia.

Exuberant thalamocortical axon arborization in cortex-specific NMDAR1 knockout mice.

Human netrin-G1 isoforms show evidence of differential expression.

Molecular evidence for two-stage learning and partial laterality in eyeblink conditioning of mice.

High-efficiency CAG-FLPe deleter mice in C57BL/6J background.

Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells.

Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice.

A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism.

Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.

Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.

Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation.

Impact of S100B on local field potential patterns in anesthetized and kainic acid-induced seizure conditions in vivo.

Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release.

Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients.

GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states.

Role of matrix metalloproteinase and tissue inhibitor of MMP in methamphetamine-induced behavioral sensitization and reward: implications for dopamine receptor down-regulation and dopamine release.

Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex.

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling.

Axonal netrin-Gs transneuronally determine lamina-specific subdendritic segments.

Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes.

Pael receptor is involved in dopamine metabolism in the nigrostriatal system.

Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice.

GABA and synaptic inhibition of mouse cerebellum lacking glutamate decarboxylase 67.

Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion.

BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier.

Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development.

Neural-activity-dependent release of S100B from astrocytes enhances kainate-induced gamma oscillations in vivo.

Lack of Connexin43-mediated bergmann glial gap junctional coupling does not affect cerebellar long-term depression, motor coordination, or eyeblink conditioning.

A novel form of memory for auditory fear conditioning at a low-intensity unconditioned stimulus.

Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility.

Dual involvement of G-substrate in motor learning revealed by gene deletion.

Connexin43 and bergmann glial gap junctions in cerebellar function.

DSCAM deficiency causes loss of pre-inspiratory neuron synchroneity and perinatal death.

Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1.

X11-like protein deficiency is associated with impaired conflict resolution in mice.

Tracing conformational transition of abnormal prion proteins during interspecies transmission by using novel antibodies.

Role of mouse hepatitis virus (MHV) receptor murine CEACAM1 in the resistance of mice to MHV infection: studies of mice with chimeric mCEACAM1a and mCEACAM1b.

Involvement of cyclin-dependent kinase-like 2 in cognitive function required for contextual and spatial learning in mice.

Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain.

Normal delay eyeblink conditioning in mice devoid of astrocytic S100B.

Identification of a novel intronic enhancer responsible for the transcriptional regulation of musashi1 in neural stem/progenitor cells.

NMDA receptors in hippocampal GABAergic synapses and their role in nitric oxide signaling.

Role of adenylate cyclase 1 in retinofugal map development.

Restoration of contralateral representation in the mouse somatosensory cortex after crossing nerve transfer.

S100B is increased in Parkinson's disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway.

Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice.

The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs.

Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses.

Genetic dissection of medial habenula-interpeduncular nucleus pathway function in mice.

Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.

Optogenetic dissection reveals multiple rhythmogenic modules underlying locomotion.

Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome.

Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells.

CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain.

Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer.

Spatiotemporal calcium dynamics in single astrocytes and its modulation by neuronal activity.

Spinal glutamatergic neurons defined by EphA4 signaling are essential components of normal locomotor circuits.

Identification of transcriptional regulatory elements for Ntng1 and Ntng2 genes in mice.

NMDAR-regulated dynamics of layer 4 neuronal dendrites during thalamocortical reorganization in neonates.

Single App knock-in mouse models of Alzheimer's disease.

Regulatory factor X transcription factors control Musashi1 transcription in mouse neural stem/progenitor cells.

RacGAP α2-chimaerin function in development adjusts cognitive ability in adulthood.

Thalamic NMDA receptor function is necessary for patterning of the thalamocortical somatosensory map and for sensorimotor behaviors.

Cdk5/p35 functions as a crucial regulator of spatial learning and memory.

Netrin-G/NGL complexes encode functional synaptic diversification.

Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice.

Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility.

S100B Up-Regulates Macrophage Production of IL1β and CCL22 and Influences Severity of Retinal Inflammation.

Supersensitive detection and discrimination of enantiomers by dorsal olfactory receptors: evidence for hierarchical odour coding.

Developmental RacGAP α2-Chimaerin Signaling Is a Determinant of the Morphological Features of Dendritic Spines in Adulthood.

Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice.

Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins.

Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice.

Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain.

Netrin-G1 regulates fear-like and anxiety-like behaviors in dissociable neural circuits.

Cognitive deficits in single App knock-in mouse models.

CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3-CA1 synapses in adult hippocampus.

Reassessment of long-term depression in cerebellar Purkinje cells in mice carrying mutated GluA2 C terminus.

Editorial.

Ventral CA1 neurons store social memory.

Antagonistic negative and positive neurons of the basolateral amygdala.

Supernova: A Versatile Vector System for Single-Cell Labeling and Gene Function Studies in vivo.

Mammalian-Specific Central Myelin Protein Opalin Is Redundant for Normal Myelination: Structural and Behavioral Assessments.

Cutting-edge approaches to unwrapping the mysteries of sleep.

Spinal RacGAP α-Chimaerin Is Required to Establish the Midline Barrier for Proper Corticospinal Axon Guidance.

The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways.

Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma.

Potentiation of excitatory synaptic transmission ameliorates aggression in mice with Stxbp1 haploinsufficiency.

Excitatory Neuronal Hubs Configure Multisensory Integration of Slow Waves in Association Cortex.

Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder.