Wyss Institute for Biologically Inspired Engineering
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Highly efficient Cas9-mediated transcriptional programming.
Nature methods Apr, 2015 | Pubmed ID: 25730490
Cas9 gRNA engineering for genome editing, activation and repression.
Nature methods Nov, 2015 | Pubmed ID: 26344044
Comparison of Cas9 activators in multiple species.
Nature methods 07, 2016 | Pubmed ID: 27214048
sgRNA Scorer 2.0: A Species-Independent Model To Predict CRISPR/Cas9 Activity.
ACS synthetic biology 05, 2017 | Pubmed ID: 28146356
Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform.
Nature microbiology Feb, 2017 | Pubmed ID: 28165460
A CRISPR-Cas9-based gene drive platform for genetic interaction analysis in Candida albicans.
Nature microbiology Oct, 2017 | Pubmed ID: 29062088
Precise Cas9 targeting enables genomic mutation prevention.
Proceedings of the National Academy of Sciences of the United States of America 04, 2018 | Pubmed ID: 29555762
CRISPR-based genomic tools for the manipulation of genetically intractable microorganisms.
Nature reviews. Microbiology Jun, 2018 | Pubmed ID: 29599458
Enabling multiplexed testing of pooled donor cells through whole-genome sequencing.
Genome medicine 04, 2018 | Pubmed ID: 29673390
An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance.
Cell Apr, 2018 | Pubmed ID: 29677511
High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR-Cas9 in yeast.
Nature biotechnology Jul, 2018 | Pubmed ID: 29786095
Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks.
Molecular cell Jul, 2018 | Pubmed ID: 29979968
An enhanced CRISPR repressor for targeted mammalian gene regulation.
Nature methods Aug, 2018 | Pubmed ID: 30013045
Sathiji Nageshwaran*,1,2,
Alejandro Chavez*,1,2,3,
Nan Cher Yeo1,2,
Xiaoge Guo1,2,
Alissa Lance-Byrne1,
Angela Tung1,
James J. Collins1,4,5,6,7,
George M. Church1,2
1Wyss Institute for Biologically Inspired Engineering, Harvard University,
2Department of Genetics, Harvard Medical School,
3Department of Pathology, Massachusetts General Hospital,
4Institute for Medical Engineering & Science, Massachusetts Institute of Technology,
5Synthetic Biology Center, Massachusetts Institute of Technology,
6Department of Biological Engineering, Massachusetts Institute of Technology,
7, Broad Institute
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