Arthur Beyder

The touchy business of gastrointestinal (GI) mechanosensitivity.

Atomic force microscopy analysis of cell volume regulation.

Electromechanical coupling in the membranes of Shaker-transfected HEK cells.

Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo.

T-type Ca(2+) channel modulation by otilonium bromide.

Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel.

Altered expression of Ano1 variants in human diabetic gastroparesis.

Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, Nav1.5.

Quantification of gastrointestinal sodium channelopathy.

Targeting ion channels for the treatment of gastrointestinal motility disorders.

Large atrial myxoma causing dynamic obstruction of the mitral valve and atrial fibrillation.

Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel Na(v)1.5: a novel mechanism of drug action.

Membrane permeable local anesthetics modulate Na(V)1.5 mechanosensitivity.

Ranolazine inhibits shear sensitivity of endogenous Na+ current and spontaneous action potentials in HL-1 cells.

Acute polyarticular gout presenting as delirium.

84-year-old man with night sweats, weight loss, and diarrhea.

Loss-of-function of the voltage-gated sodium channel NaV1.5 (channelopathies) in patients with irritable bowel syndrome.

Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces.

Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells.

A novel exon in the human Ca2+-activated Cl- channel Ano1 imparts greater sensitivity to intracellular Ca2.

Expression and function of the Scn5a-encoded voltage-gated sodium channel NaV 1.5 in the rat jejunum.

39-Year-Old Man With Dysphagia.

Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces.

Ion channelopathies in functional GI disorders.

Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice.

polymorphisms associated with increased risk of IBS-C and IBS-M.

XIVth Little Brain Big Brain: next-generation enteric neuroscience.

Mechanosensory Signaling in Enterochromaffin Cells and 5-HT Release: Potential Implications for Gut Inflammation.

Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4.

EAVK segment "c" sequence confers Ca-dependent changes to the kinetics of full-length human Ano1.

Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT receptor expression via acetate production.

47-Year-Old Man With Abdominal Pain and Diarrhea.

Sodium channel Na1.3 is important for enterochromaffin cell excitability and serotonin release.

Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased Na1.5 current and mechanosensitivity.

Gut development on a full stomach.

A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release.

Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing.

In Pursuit of the Epithelial Mechanosensitivity Mechanisms.

Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension.

mutation G615E results in Na1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity.

Telocytes express ANO-1-encoded chloride channels in canine ventricular myocardium.

TRPPing up bronchiectasis.

microRNA overexpression in slow transit constipation leads to reduced Na1.5 current and altered smooth muscle contractility.

A Method for Multi-day Tracking of Gastrointestinal Smooth Muscle Contractile Patterns in Organotypic Culture.

NACHO and 14-3-3 promote expression of distinct subunit stoichiometries of the α4β2 acetylcholine receptor.

Identification of intrinsic primary afferent neurons in mouse jejunum.

A simple automated approach to measure mouse whole gut transit.

Gastric ablation as a novel technique for modulating electrical conduction in the in vivo stomach.

Mechanotransduction in gastrointestinal smooth muscle cells: role of mechanosensitive ion channels.

Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease.

Specialized Mechanosensory Epithelial Cells in Mouse Gut Intrinsic Tactile Sensitivity.

Gut feelings: mechanosensing in the gastrointestinal tract.

Targeted ablation of gastric pacemaker sites to modulate patterns of bioelectrical slow wave activation and propagation in an anesthetized pig model.