Patricia and John Rosenwald Laboratory of Neurobiology and Genetics
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Tissue plasminogen activator in nervous system function and dysfunction.
Thrombosis and haemostasis Jul, 2001 | Pubmed ID: 11486999
Localization and regulation of the tissue plasminogen activator-plasmin system in the hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2002 | Pubmed ID: 11896152
Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation.
Neuron Mar, 2002 | Pubmed ID: 11906694
Nervous system pathology: the fibrin perspective.
Biological chemistry Jan, 2002 | Pubmed ID: 11928820
Tissue plasminogen activator and seizures: a clot-buster's secret life.
The Journal of clinical investigation Jun, 2002 | Pubmed ID: 12070298
Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior.
Nature neuroscience Feb, 2003 | Pubmed ID: 12524546
Fibrin is a regulator of Schwann cell migration after sciatic nerve injury in mice.
Neuroscience letters Mar, 2003 | Pubmed ID: 12581827
The hippocampal laminin matrix is dynamic and critical for neuronal survival.
Molecular biology of the cell Jul, 2003 | Pubmed ID: 12857855
The possible role of tissue-type plasminogen activator (tPA) and tPA blockers in the pathogenesis and treatment of Alzheimer's disease.
Journal of molecular neuroscience : MN , 2003 | Pubmed ID: 14501010
The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2003 | Pubmed ID: 14523088
Laminin gamma1 is critical for Schwann cell differentiation, axon myelination, and regeneration in the peripheral nerve.
The Journal of cell biology Nov, 2003 | Pubmed ID: 14638863
Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2004 | Pubmed ID: 15096619
Tissue plasminogen activator promotes the effects of corticotropin-releasing factor on the amygdala and anxiety-like behavior.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2004 | Pubmed ID: 15522965
Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2005 | Pubmed ID: 15630096
Tissue plasminogen activator in central nervous system physiology and pathology.
Thrombosis and haemostasis Apr, 2005 | Pubmed ID: 15841309
Schwann cell-specific ablation of laminin gamma1 causes apoptosis and prevents proliferation.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2005 | Pubmed ID: 15872093
Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2005 | Pubmed ID: 16330749
The plasminogen activator system modulates sympathetic nerve function.
The Journal of experimental medicine Sep, 2006 | Pubmed ID: 16940168
Peripheral regeneration.
Annual review of neuroscience , 2007 | Pubmed ID: 17341159
Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease.
The Journal of experimental medicine Aug, 2007 | Pubmed ID: 17664291
Modulation of NR2B-regulated contextual fear in the hippocampus by the tissue plasminogen activator system.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2007 | Pubmed ID: 17673549
Key role of tissue plasminogen activator in neurovascular coupling.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2008 | Pubmed ID: 18195371
Disruption of laminin in the peripheral nervous system impedes nonmyelinating Schwann cell development and impairs nociceptive sensory function.
Glia Jun, 2009 | Pubmed ID: 19053061
Proteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptor.
The Journal of cell biology Dec, 2008 | Pubmed ID: 19114596
Cortical deficiency of laminin gamma1 impairs the AKT/GSK-3beta signaling pathway and leads to defects in neurite outgrowth and neuronal migration.
Developmental biology Mar, 2009 | Pubmed ID: 19118544
Tissue plasminogen activator modulates the cellular and behavioral response to cocaine.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2009 | Pubmed ID: 19181855
Laminin is required for Schwann cell morphogenesis.
Journal of cell science Apr, 2009 | Pubmed ID: 19295124
Plasmin-mediated degradation of laminin gamma-1 is critical for ethanol-induced neurodegeneration.
Biological psychiatry Oct, 2009 | Pubmed ID: 19577227
Maximum-entropy network analysis reveals a role for tumor necrosis factor in peripheral nerve development and function.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2009 | Pubmed ID: 19597151
Fibrinogen and beta-amyloid association alters thrombosis and fibrinolysis: a possible contributing factor to Alzheimer's disease.
Neuron Jun, 2010 | Pubmed ID: 20547128
Involvement of tissue plasminogen activator in stress responsivity during acute cocaine withdrawal in mice.
Stress (Amsterdam, Netherlands) Nov, 2010 | Pubmed ID: 20666641
Alzheimer's disease peptide beta-amyloid interacts with fibrinogen and induces its oligomerization.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2010 | Pubmed ID: 21098282
Mesenchymal stem cells facilitate axon sorting, myelination, and functional recovery in paralyzed mice deficient in Schwann cell-derived laminin.
Glia Feb, 2011 | Pubmed ID: 21125647
Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2011 | Pubmed ID: 21383198
Renal collecting system growth and function depend upon embryonic γ1 laminin expression.
Development (Cambridge, England) Oct, 2011 | Pubmed ID: 21903675
Aβ delays fibrin clot lysis by altering fibrin structure and attenuating plasminogen binding to fibrin.
Blood Apr, 2012 | Pubmed ID: 22238323
Schwann cell myelination requires integration of laminin activities.
Journal of cell science Oct, 2012 | Pubmed ID: 22767514
Fibrinogen and altered hemostasis in Alzheimer's disease.
Journal of Alzheimer's disease : JAD , 2012 | Pubmed ID: 22869464
The GluK4 kainate receptor subunit regulates memory, mood, and excitotoxic neurodegeneration.
Neuroscience Apr, 2013 | Pubmed ID: 23357115
The APOE ɛ4/ɛ4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Aug, 2013 | Pubmed ID: 23652625
Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke.
The Journal of cell biology Jul, 2013 | Pubmed ID: 23857767
Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity.
Nature communications Mar, 2014 | Pubmed ID: 24583950
Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brain.
Journal of thrombosis and haemostasis : JTH May, 2014 | Pubmed ID: 24612416
A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice.
The Journal of experimental medicine Jun, 2014 | Pubmed ID: 24821909
The cellular origin of laminin determines its role in blood pressure regulation.
Cellular and molecular life sciences : CMLS Mar, 2015 | Pubmed ID: 25216704
Fibrin deposited in the Alzheimer's disease brain promotes neuronal degeneration.
Neurobiology of aging Feb, 2015 | Pubmed ID: 25475538
Activation of the factor XII-driven contact system in Alzheimer's disease patient and mouse model plasma.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2015 | Pubmed ID: 25775543
Chronic Hypertension Leads to Neurodegeneration in the TgSwDI Mouse Model of Alzheimer's Disease.
Hypertension (Dallas, Tex. : 1979) Jul, 2015 | Pubmed ID: 25941345
The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII.
Journal of thrombosis and haemostasis : JTH 05, 2016 | Pubmed ID: 26613657
Hyperhomocysteinemia exacerbates Alzheimer's disease pathology by way of the β-amyloid fibrinogen interaction.
Journal of thrombosis and haemostasis : JTH 07, 2016 | Pubmed ID: 27090576
Laminin regulates PDGFRβ(+) cell stemness and muscle development.
Nature communications May, 2016 | Pubmed ID: 27138650
A possible new role for Aβ in vascular and inflammatory dysfunction in Alzheimer's disease.
Thrombosis research May, 2016 | Pubmed ID: 27207427
Biochemical and structural analysis of the interaction between β-amyloid and fibrinogen.
Blood 08, 2016 | Pubmed ID: 27389717
Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice.
Blood 05, 2017 | Pubmed ID: 28242605
Interactions of β-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's disease.
Current opinion in hematology Sep, 2017 | Pubmed ID: 28661939
Fibrinogen in the Nervous System: Glia Beware.
Neuron Dec, 2017 | Pubmed ID: 29216454
Aminopyrimidine Class Aggregation Inhibitor Effectively Blocks Aβ-Fibrinogen Interaction and Aβ-Induced Contact System Activation.
Biochemistry 02, 2018 | Pubmed ID: 29394041
Abnormal clotting of the intrinsic/contact pathway in Alzheimer disease patients is related to cognitive ability.
Blood advances May, 2018 | Pubmed ID: 29700007
Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 10, 2018 | Pubmed ID: 30254165
A novel detection method of cleaved plasma high-molecular-weight kininogen reveals its correlation with Alzheimer's pathology and cognitive impairment.
Alzheimer's & dementia (Amsterdam, Netherlands) , 2018 | Pubmed ID: 30310850
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