Ke Zheng
State Key Laboratory of Reproductive Medicine
Nanjing Medical University
Dr. Ke Zheng got his Ph.D. degree in genetics at Zhejiang University, China. Dr. Zheng started his research career in the United States from 2007 as a postdoctoral fellow in Dr. P. Jeremy Wang’s lab at the University of Pennsylvania, during which Dr. Zheng got the Bayard T. Storey Award for Excellence in Research. Dr. Zheng is now a professor at the State Key Laboratory of Reproductive Medicine (SKLRM), Nanjing Medical University. Dr. Zheng’s laboratory is interested in exploring how non-coding RNAs act on regulation of male germline development. Currently, Dr. Zheng’s researches focus on piRNA biogenesis and function in mammalian spermatogenesis by employing cross-disciplinary approaches to reproductive science.
Taf7l cooperates with Trf2 to regulate spermiogenesis.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2013 | Pubmed ID: 24082143
The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing.
Genes & development Mar, 2015 | Pubmed ID: 25762440
Conditional ablation of in the male germline causes infertility due to meiotic arrest and impaired inactivation of sex chromosomes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 09, 2017 | Pubmed ID: 28490482
An essential role for PNLDC1 in piRNA 3' end trimming and male fertility in mice.
Cell research Nov, 2017 | Pubmed ID: 28994417
Differential regulation of spermatogenic process by Lkb1 isoforms in mouse testis.
Cell death & disease 10, 2017 | Pubmed ID: 29022902
A germline-specific role for the mTORC2 component Rictor in maintaining spermatogonial differentiation and intercellular adhesion in mouse testis.
Molecular human reproduction May, 2018 | Pubmed ID: 29518209
Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes.
Development (Cambridge, England) 07, 2018 | Pubmed ID: 29866902
Rapamycin-mediated mTOR inhibition impairs silencing of sex chromosomes and the pachytene piRNA pathway in the mouse testis.
Aging Jan, 2019 | Pubmed ID: 30636722
Biological and RNA regulatory function of MOV10 in mammalian germ cells.
BMC biology May, 2019 | Pubmed ID: 31088452
MOV10L1 Binds RNA G-Quadruplex in a Structure-Specific Manner and Resolves It More Efficiently Than MOV10.
iScience Jun, 2019 | Pubmed ID: 31252377
Characteristics and Workload of Pediatricians in China.
Pediatrics Jul, 2019 | Pubmed ID: 31253739
In Vitro Biochemical Assays using Biotin Labels to Study Protein-Nucleic Acid Interactions
Lina Yu*,1,
Wenxiu He*,1,
Jie Xie*,1,
Rui Guo*,1,
Juan Ni2,
Xia Zhang3,
Quishi Xu1,
Caifeng Wang1,
Qiuling Yue1,
Fangfang Li1,
Mengcheng Luo4,
Bo Sun3,
Lan Ye1,
Ke Zheng1
1State Key Laboratory of Reproductive Medicine, Nanjing Medical University,
2, The Affiliated Hospital of Hangzhou Normal University,
3School of Life Science and Technology, ShanghaiTech University,
4Department of Tissue and Embryology, School of Basic Medical Sciences, Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan University
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