Yoshimasa Takahashi

Ras mediates effector pathways responsible for pre-B cell survival, which is essential for the developmental progression to the late pre-B cell stage.

Isotype-specific selection of high affinity memory B cells in nasal-associated lymphoid tissue.

Studies on the generation and maintenance of mucosal cytotoxic T lymphocytes against human immunodeficiency virus type 1 Gag in mice.

Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses.

A subcutaneously injected UV-inactivated SARS coronavirus vaccine elicits systemic humoral immunity in mice.

Two waves of memory B-cell generation in the primary immune response.

Immunological detection of severe acute respiratory syndrome coronavirus by monoclonal antibodies.

Novel role of the Ras cascade in memory B cell response.

Formalin-treated UV-inactivated SARS coronavirus vaccine retains its immunogenicity and promotes Th2-type immune responses.

Memory B cells in systemic and mucosal immune response: implications for successful vaccination.

Protective immunity afforded by inactivated H5N1 (NIBRG-14) vaccine requires antibodies against both hemagglutinin and neuraminidase in mice.

CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions.

Inactivated and adjuvanted whole-virion clade 2.3.4 H5N1 pre-pandemic influenza vaccine possesses broad protective efficacy against infection by heterologous clades of highly pathogenic H5N1 avian influenza virus in mice.

Newly established monoclonal antibodies for immunological detection of H5N1 influenza virus.

Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection.

Primary and secondary B-cell responses to pulmonary virus infection.

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory.

Influenza A whole virion vaccine induces a rapid reduction of peripheral blood leukocytes via interferon-α-dependent apoptosis.

Both mutated and unmutated memory B cells accumulate mutations in the course of the secondary response and develop a new antibody repertoire optimally adapted to the secondary stimulus.

Oral administration of Lactobacillus plantarum strain AYA enhances IgA secretion and provides survival protection against influenza virus infection in mice.

Epitope mapping of the hemagglutinin molecule of A/(H1N1)pdm09 influenza virus by using monoclonal antibody escape mutants.

Distinct germinal center selection at local sites shapes memory B cell response to viral escape.

EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity.

Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis.

Whole-Virion Influenza Vaccine Recalls an Early Burst of High-Affinity Memory B Cell Response through TLR Signaling.

Regulated selection of germinal-center cells into the memory B cell compartment.

Protective neutralizing influenza antibody response in the absence of T follicular helper cells.

Boosting of post-exposure human T-cell and B-cell recall responses in vivo by Burkholderia pseudomallei-related proteins.

Role of germinal centers for the induction of broadly-reactive memory B cells.

A humanized mouse model identifies key amino acids for low immunogenicity of H7N9 vaccines.

Adaptive B Cell Responses to Influenza Virus Infection in the Lung.

A unique nanoparticulate TLR9 agonist enables a HA split vaccine to confer FcγR-mediated protection against heterologous lethal influenza virus infection.

Efficient protection of mice from influenza A/H1N1pdm09 virus challenge infection via high avidity serum antibodies induced by booster immunizations with inactivated whole virus vaccine.