Scott A. Weed

Dynamin2 and cortactin regulate actin assembly and filament organization.

Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion.

MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts.

Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton.

Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow-derived macrophages.

Characterization of an ankyrin repeat-containing Shank2 isoform (Shank2E) in liver epithelial cells.

Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization.

Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase.

Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells.

Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110.

Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification.

Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma.

PI3K activation is required for PMA-directed activation of cSrc by AFAP-110.

Actin cytoskeletal mediators of motility and invasion amplified and overexpressed in head and neck cancer.

Phosphorylation of AFAP-110 affects podosome lifespan in A7r5 cells.

Cortactin branches out: roles in regulating protrusive actin dynamics.

Cortactin is a functional target of E-cadherin-activated Src family kinases in MCF7 epithelial monolayers.

Saracatinib Impairs Head and Neck Squamous Cell Carcinoma Invasion by Disrupting Invadopodia Function.

Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation.

Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence.

Revisiting the ERK/Src cortactin switch.

Further insights into cortactin conformational regulation.

Effects of Tobacco Smoking and Nicotine on Cancer Treatment.

Cortactin is a substrate of activated Cdc42-associated kinase 1 (ACK1) during ligand-induced epidermal growth factor receptor downregulation.

Effects of tobacco smoking and nicotine on cancer treatment.

Src binds cortactin through an SH2 domain cystine-mediated linkage.

Phosphorylation of the alternative mRNA splicing factor 45 (SPF45) by Clk1 regulates its splice site utilization, cell migration and invasion.

Metastatic MTLn3 and non-metastatic MTC adenocarcinoma cells can be differentiated by Pseudomonas aeruginosa.

NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis.

Recently identified biomarkers that promote lymph node metastasis in head and neck squamous cell carcinoma.

NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner.

Use of high frequency ultrasound to monitor cervical lymph node alterations in mice.

Tumor and stromal-based contributions to head and neck squamous cell carcinoma invasion.