Chemistry and Chemical Engineering
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Analysis of shuffled gene libraries.
Journal of molecular biology Feb, 2002 | Pubmed ID: 11866523
A colorimetric assay to quantify dehydrogenase activity in crude cell lysates.
Journal of biomolecular screening Apr, 2002 | Pubmed ID: 12006112
Protein engineering of oxygenases for biocatalysis.
Current opinion in chemical biology Apr, 2002 | Pubmed ID: 12038995
Protein building blocks preserved by recombination.
Nature structural biology Jul, 2002 | Pubmed ID: 12042875
An integrated microfabricated cell sorter.
Analytical chemistry Jun, 2002 | Pubmed ID: 12069222
Modification of galactose oxidase to introduce glucose 6-oxidase activity.
Chembiochem : a European journal of chemical biology Aug, 2002 | Pubmed ID: 12203977
Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase.
Nature biotechnology Nov, 2002 | Pubmed ID: 12368811
Evolution of the C30 carotenoid synthase CrtM for function in a C40 pathway.
Journal of bacteriology Dec, 2002 | Pubmed ID: 12426357
Directed evolution of a genetic circuit.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2002 | Pubmed ID: 12451174
Functional expression of a fungal laccase in Saccharomyces cerevisiae by directed evolution.
Applied and environmental microbiology Feb, 2003 | Pubmed ID: 12571021
Protein dynamics in a family of laboratory evolved thermophilic enzymes.
Journal of molecular biology Mar, 2003 | Pubmed ID: 12634066
A C35 carotenoid biosynthetic pathway.
Applied and environmental microbiology Jun, 2003 | Pubmed ID: 12788765
General method for sequence-independent site-directed chimeragenesis.
Journal of molecular biology Jul, 2003 | Pubmed ID: 12823968
Staggered extension process (StEP) in vitro recombination.
Methods in molecular biology (Clifton, N.J.) , 2003 | Pubmed ID: 12824608
Library analysis of SCHEMA-guided protein recombination.
Protein science : a publication of the Protein Society Aug, 2003 | Pubmed ID: 12876318
A self-sufficient peroxide-driven hydroxylation biocatalyst.
Angewandte Chemie (International ed. in English) Jul, 2003 | Pubmed ID: 12876749
Global incorporation of norleucine in place of methionine in cytochrome P450 BM-3 heme domain increases peroxygenase activity.
Biotechnology and bioengineering Sep, 2003 | Pubmed ID: 12889037
Method to protect a targeted amino acid residue during random mutagenesis.
Nucleic acids research Aug, 2003 | Pubmed ID: 12907743
Engineering proteins that bind, move, make and break DNA.
Current opinion in biotechnology Aug, 2003 | Pubmed ID: 12943845
Thermostabilization of a cytochrome p450 peroxygenase.
Chembiochem : a European journal of chemical biology Sep, 2003 | Pubmed ID: 12964165
Regio- and enantioselective alkane hydroxylation with engineered cytochromes P450 BM-3.
Journal of the American Chemical Society Nov, 2003 | Pubmed ID: 14583039
Colorimetric assays for biodegradation of polycyclic aromatic hydrocarbons by fungal laccases.
Journal of biomolecular screening Dec, 2002 | Pubmed ID: 14599353
Engineering proteins that bind, move, make and break DNA.
Current opinion in biotechnology Dec, 2003 | Pubmed ID: 14662399
Laboratory evolution of cytochrome p450 BM-3 monooxygenase for organic cosolvents.
Biotechnology and bioengineering Feb, 2004 | Pubmed ID: 14748091
Evolution of a pathway to novel long-chain carotenoids.
Journal of bacteriology Mar, 2004 | Pubmed ID: 14973014
Colorimetric high-throughput assay for alkene epoxidation catalyzed by cytochrome P450 BM-3 variant 139-3.
Journal of biomolecular screening Mar, 2004 | Pubmed ID: 15006137
Programmed population control by cell-cell communication and regulated killing.
Nature Apr, 2004 | Pubmed ID: 15064770
Stability and the evolvability of function in a model protein.
Biophysical journal May, 2004 | Pubmed ID: 15111394
Functional evolution and structural conservation in chimeric cytochromes p450: calibrating a structure-guided approach.
Chemistry & biology Mar, 2004 | Pubmed ID: 15123260
SCHEMA-guided protein recombination.
Methods in enzymology , 2004 | Pubmed ID: 15289059
Reduction of dioxygen catalyzed by pyrene-wired heme domain cytochrome P450 BM3 electrodes.
Journal of the American Chemical Society Aug, 2004 | Pubmed ID: 15315414
Site-directed protein recombination as a shortest-path problem.
Protein engineering, design & selection : PEDS Jul, 2004 | Pubmed ID: 15331774
Cobaltocene-mediated catalytic monooxygenation using holo and heme domain cytochrome P450 BM3.
Journal of inorganic biochemistry Sep, 2004 | Pubmed ID: 15337607
Association of antigens to ISCOMATRIX adjuvant using metal chelation leads to improved CTL responses.
Vaccine Sep, 2004 | Pubmed ID: 15364446
Thermodynamic prediction of protein neutrality.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2005 | Pubmed ID: 15644440
Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactones.
Molecular microbiology Feb, 2005 | Pubmed ID: 15660998
Diversifying carotenoid biosynthetic pathways by directed evolution.
Microbiology and molecular biology reviews : MMBR Mar, 2005 | Pubmed ID: 15755953
On the conservative nature of intragenic recombination.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2005 | Pubmed ID: 15809422
A synthetic multicellular system for programmed pattern formation.
Nature Apr, 2005 | Pubmed ID: 15858574
Stereoselective hydroxylation of an achiral cyclopentanecarboxylic acid derivative using engineered P450s BM-3.
Chemical communications (Cambridge, England) May, 2005 | Pubmed ID: 15900339
Protein-surfactant film voltammetry of wild-type and mutant cytochrome P450 BM3.
Inorganic chemistry Jun, 2005 | Pubmed ID: 15934729
Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins.
Journal of molecular biology Jul, 2005 | Pubmed ID: 15939434
Long-term monitoring of bacteria undergoing programmed population control in a microchemostat.
Science (New York, N.Y.) Jul, 2005 | Pubmed ID: 15994559
Evolving strategies for enzyme engineering.
Current opinion in structural biology Aug, 2005 | Pubmed ID: 16006119
Direct conversion of ethane to ethanol by engineered cytochrome P450 BM3.
Chembiochem : a European journal of chemical biology Oct, 2005 | Pubmed ID: 16080215
Why highly expressed proteins evolve slowly.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2005 | Pubmed ID: 16176987
Preparation of human metabolites of propranolol using laboratory-evolved bacterial cytochromes P450.
Biotechnology and bioengineering Feb, 2006 | Pubmed ID: 16224788
Enantioselective epoxidation of terminal alkenes to (R)- and (S)-epoxides by engineered cytochromes P450 BM-3.
Chemistry (Weinheim an der Bergstrasse, Germany) Jan, 2006 | Pubmed ID: 16240317
Biosynthesis of novel carotenoid families based on unnatural carbon backbones: a model for diversification of natural product pathways.
Biochimica et biophysica acta Feb, 2006 | Pubmed ID: 16478677
Fancy footwork in the sequence space shuffle.
Nature biotechnology Mar, 2006 | Pubmed ID: 16525408
Protein stability promotes evolvability.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2006 | Pubmed ID: 16581913
Structure-guided recombination creates an artificial family of cytochromes P450.
PLoS biology May, 2006 | Pubmed ID: 16594730
Enantioselective alpha-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3.
Journal of the American Chemical Society May, 2006 | Pubmed ID: 16669674
Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR.
Nature biotechnology Jun, 2006 | Pubmed ID: 16715074
Structural determinants of the rate of protein evolution in yeast.
Molecular biology and evolution Sep, 2006 | Pubmed ID: 16782762
Structure-guided SCHEMA recombination of distantly related beta-lactamases.
Protein engineering, design & selection : PEDS Dec, 2006 | Pubmed ID: 17090554
Synthetic gene circuits: design with directed evolution.
Annual review of biophysics and biomolecular structure , 2007 | Pubmed ID: 17243895
Breaking proteins with mutations: threads and thresholds in evolution.
Molecular systems biology , 2007 | Pubmed ID: 17262035
Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s.
Chemistry & biology Mar, 2007 | Pubmed ID: 17379142
Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution.
Biology direct , 2007 | Pubmed ID: 17598905
Evolution favors protein mutational robustness in sufficiently large populations.
BMC biology , 2007 | Pubmed ID: 17640347
Directed evolution of Vibrio fischeri LuxR for improved response to butanoyl-homoserine lactone.
Applied and environmental microbiology Sep, 2007 | Pubmed ID: 17675429
A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments.
Nature biotechnology Sep, 2007 | Pubmed ID: 17721510
Engineering by homologous recombination: exploring sequence and function within a conserved fold.
Current opinion in structural biology Aug, 2007 | Pubmed ID: 17884462
Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties.
Angewandte Chemie (International ed. in English) , 2007 | Pubmed ID: 17886313
Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2007 | Pubmed ID: 17959781
Implications of rewiring bacterial quorum sensing.
Applied and environmental microbiology Jan, 2008 | Pubmed ID: 18039819
A synthetic Escherichia coli predator-prey ecosystem.
Molecular systems biology , 2008 | Pubmed ID: 18414488
Combinatorial recombination of gene fragments to construct a library of chimeras.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] Jun, 2006 | Pubmed ID: 18429308
Evolutionary history of a specialized p450 propane monooxygenase.
Journal of molecular biology Nov, 2008 | Pubmed ID: 18619466
Engineering microbial consortia: a new frontier in synthetic biology.
Trends in biotechnology Sep, 2008 | Pubmed ID: 18675483
In vivo evolution of butane oxidation by terminal alkane hydroxylases AlkB and CYP153A6.
Applied and environmental microbiology Jan, 2009 | Pubmed ID: 19011057
Chemo-enzymatic fluorination of unactivated organic compounds.
Nature chemical biology Jan, 2009 | Pubmed ID: 19011638
Directed enzyme evolution: climbing fitness peaks one amino acid at a time.
Current opinion in chemical biology Feb, 2009 | Pubmed ID: 19249235
A family of thermostable fungal cellulases created by structure-guided recombination.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2009 | Pubmed ID: 19307582
In the light of directed evolution: pathways of adaptive protein evolution.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2009 | Pubmed ID: 19528653
SCHEMA recombination of a fungal cellulase uncovers a single mutation that contributes markedly to stability.
The Journal of biological chemistry Sep, 2009 | Pubmed ID: 19625252
Directed evolution: new parts and optimized function.
Current opinion in biotechnology Aug, 2009 | Pubmed ID: 19720520
A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds.
Chemistry (Weinheim an der Bergstrasse, Germany) Nov, 2009 | Pubmed ID: 19774562
Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450BM3 demethylases.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2009 | Pubmed ID: 19805336
Exploring protein fitness landscapes by directed evolution.
Nature reviews. Molecular cell biology Dec, 2009 | Pubmed ID: 19935669
Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine.
Nature biotechnology Mar, 2010 | Pubmed ID: 20190737
Consensus protein design without phylogenetic bias.
Journal of molecular biology Jun, 2010 | Pubmed ID: 20433850
Combinatorial recombination of gene fragments to construct a library of chimeras.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] Aug, 2010 | Pubmed ID: 20814931
A general mechanism for network-dosage compensation in gene circuits.
Science (New York, N.Y.) Sep, 2010 | Pubmed ID: 20929850
Enzymatic functionalization of carbon-hydrogen bonds.
Chemical Society reviews Apr, 2011 | Pubmed ID: 21079862
Combinatorial alanine substitution enables rapid optimization of cytochrome P450BM3 for selective hydroxylation of large substrates.
Chembiochem : a European journal of chemical biology Dec, 2010 | Pubmed ID: 21108271
Comparison of family 9 cellulases from mesophilic and thermophilic bacteria.
Applied and environmental microbiology Feb, 2011 | Pubmed ID: 21169454
Metal-substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity.
Journal of the American Chemical Society Feb, 2011 | Pubmed ID: 21171606
Optimizing non-natural protein function with directed evolution.
Current opinion in chemical biology Apr, 2011 | Pubmed ID: 21185770
Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli.
Biotechnology and bioengineering Mar, 2011 | Pubmed ID: 21246504
Self-organization, layered structure, and aggregation enhance persistence of a synthetic biofilm consortium.
PloS one , 2011 | Pubmed ID: 21347422
Cytochrome P450: taming a wild type enzyme.
Current opinion in biotechnology Dec, 2011 | Pubmed ID: 21411308
Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli.
Metabolic engineering May, 2011 | Pubmed ID: 21515217
A structural study of Hypocrea jecorina Cel5A.
Protein science : a publication of the Protein Society Nov, 2011 | Pubmed ID: 21898652
Reversal of NAD(P)H cofactor dependence by protein engineering.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22144350
Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes.
Protein engineering, design & selection : PEDS Feb, 2012 | Pubmed ID: 22334757
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