Christian S. Thudium

Dissociation of bone resorption and bone formation in adult mice with a non-functional V-ATPase in osteoclasts leads to increased bone strength.

A specific subtype of osteoclasts secretes factors inducing nodule formation by osteoblasts.

Osteoclasts are not crucial for hematopoietic stem cell maintenance in adult mice.

A comparison of osteoclast-rich and osteoclast-poor osteopetrosis in adult mice sheds light on the role of the osteoclast in coupling bone resorption and bone formation.

Forced expression of human macrophage colony-stimulating factor in CD34 cells promotes monocyte differentiation in vitro and in vivo but blunts osteoclastogenesis in vitro.

Biomarker of extracellular matrix remodelling C1M and proinflammatory cytokine interleukin 6 are related to synovitis and pain in end-stage knee osteoarthritis patients.

Biochemical marker discovery, testing and evaluation for facilitating OA drug discovery and development.

Development and use of biochemical markers in osteoarthritis: current update.

IL-6 receptor inhibition modulates type III collagen and C-reactive protein degradation in rheumatoid arthritis patients with an inadequate response to anti-tumour necrosis factor therapy: analysis of connective tissue turnover in the tocilizumab RADIATE study.

Osteoclasts degrade bone and cartilage knee joint compartments through different resorption processes.

Translational Biomarkers and Ex Vivo Models of Joint Tissues as a Tool for Drug Development in Rheumatoid Arthritis.

Protein biomarkers associated with pain mechanisms in osteoarthritis.

Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo.

Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model.

GPDPLQ-A Type II Collagen Neo-Epitope Biomarker of Osteoclast- and Inflammation-Derived Cartilage Degradation in vitro.

A dual amylin and calcitonin receptor agonist inhibits pain behavior and reduces cartilage pathology in an osteoarthritis rat model.