Toshiaki Furuta
Department of Biomolecular Science,
Faculty of Science,
Department of Biomolecular Science, Faculty of Science
Toho University
Toshiaki Furuta is a Professor in the Department of Biomolecular Science, Faculty of Science, Toho University (Narashino Campus) in Funabashi, Japan. He received his undergraduate and Ph.D. from Tohoku University, Sendai, Japan under the guidance of Professor Emeritus Yoshinori Yamamoto. During his Ph.D. years, he studied the total syntheses of natural products and acyclic stereocontrol using organometallic compounds. In 1990, he was appointed as an assistant professor at the Chemistry Department, Tohoku University, and then moved to Toho University where he started his chemical biology work. As a post-doctoral fellow (1997-1998) in Roger Y. Tsien’s lab at the Department of Pharmacology, UC, San Diego, La Jolla, California, he designed and synthesized a new type of caging group with improved photochemical properties under one and two-photon excitation conditions. His current research programs focus on the development of photo-caging groups that can target specified cells to expand the usefulness of caged compounds.
Anthraquinon-2-ylmethoxycarbonyl (Aqmoc): a new photochemically removable protecting group for alcohols.
Organic letters Jun, 2001 | Pubmed ID: 11405717
Design, synthesis, photochemical properties and cytotoxic activities of water-soluble caged L-leucyl-L-leucine methyl esters that control apoptosis of immune cells.
Bioorganic & medicinal chemistry Mar, 2002 | Pubmed ID: 11814855
Design, synthesis and photochemical properties of caged bile acids.
Bioorganic & medicinal chemistry letters Mar, 2003 | Pubmed ID: 12617918
Coumarin-4-ylmethoxycarbonyls as phototriggers for alcohols and phenols.
Organic letters Dec, 2003 | Pubmed ID: 14653694
Bhc-cNMPs as either water-soluble or membrane-permeant photoreleasable cyclic nucleotides for both one- and two-photon excitation.
Chembiochem : a European journal of chemical biology Aug, 2004 | Pubmed ID: 15300837
Real-time analysis of the role of Ca(2+) in flagellar movement and motility in single sea urchin sperm.
The Journal of cell biology Jun, 2005 | Pubmed ID: 15928204
Crystallographic evidence for water-assisted photo-induced peptide cleavage in the stony coral fluorescent protein Kaede.
Journal of molecular biology Sep, 2007 | Pubmed ID: 17692334
Phototriggers for nucleobases with improved photochemical properties.
Organic letters Nov, 2007 | Pubmed ID: 17929824
[Use of caged compounds for the study of transient complexes].
Seikagaku. The Journal of Japanese Biochemical Society Oct, 2011 | Pubmed ID: 22184890
Design, synthesis, and photochemistry of modular caging groups for photoreleasable nucleotides.
Organic letters Dec, 2012 | Pubmed ID: 23205776
Preparation and affinity-based purification of caged linear DNA for light-controlled gene expression in mammalian cells.
Chemical communications (Cambridge, England) Jan, 2014 | Pubmed ID: 24282826
Synthesis of nucleobase-caged peptide nucleic acids having improved photochemical properties.
Organic & biomolecular chemistry Jul, 2014 | Pubmed ID: 24921960
A double bond-conjugated dimethylnitrobenzene-type photolabile nitric oxide donor with improved two-photon cross section.
Bioorganic & medicinal chemistry letters Aug, 2015 | Pubmed ID: 26073004
Utilization of the Heavy Atom Effect for the Development of a Photosensitive 8-Azacoumarin-Type Photolabile Protecting Group.
Organic letters Nov, 2015 | Pubmed ID: 26469518
Red fluorescent cAMP indicator with increased affinity and expanded dynamic range.
Scientific reports 01, 2018 | Pubmed ID: 29382930
7-Hydroxy- N-Methylquinolinium Chromophore: A Photolabile Protecting Group for Blue-Light Uncaging.
Organic letters 07, 2018 | Pubmed ID: 29957954
A clickable caging group as a new platform for modular caged compounds with improved photochemical properties.
Chemical communications (Cambridge, England) Jan, 2019 | Pubmed ID: 30451249
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