Department of Biochemistry
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CD4(+) T-cell- and gamma interferon-dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoelii 17-kilodalton hepatocyte erythrocyte protein.
Infection and immunity Nov, 1999 | Pubmed ID: 10531206
A subdominant CD8(+) cytotoxic T lymphocyte (CTL) epitope from the Plasmodium yoelii circumsporozoite protein induces CTLs that eliminate infected hepatocytes from culture.
Infection and immunity Jun, 2000 | Pubmed ID: 10816491
Recognition of synthetic polypeptides corresponding to the N- and C-terminal fragments of Plasmodium falciparum Exp-1 by T-cells and plasma from human donors from African endemic areas.
Parasite immunology Mar, 2002 | Pubmed ID: 11982859
IL-12 administration leads to a transient depletion of T cells, B cells, and APCs and concomitant abrogation of the HLA-A2.1-restricted CTL response in transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2002 | Pubmed ID: 12077229
Peptide vaccination.
Methods in molecular medicine , 2002 | Pubmed ID: 12125130
Assessment of antigen-specific CTL- and CD8(+)-dependent IFN-gamma responses in mice.
Methods in molecular medicine , 2002 | Pubmed ID: 12125139
Novel peptide inhibitors of Leishmania gp63 based on the cleavage site of MARCKS (myristoylated alanine-rich C kinase substrate)-related protein.
The Biochemical journal Nov, 2002 | Pubmed ID: 12137567
Encapsulation of peptides in biodegradable microspheres prolongs their MHC class-I presentation by dendritic cells and macrophages in vitro.
Vaccine Mar, 2003 | Pubmed ID: 12559806
OM-174, a new adjuvant with a potential for human use, induces a protective response when administered with the synthetic C-terminal fragment 242-310 from the circumsporozoite protein of Plasmodium berghei.
Vaccine Jun, 2003 | Pubmed ID: 12744882
In vivo targeting of an anti-tumor antibody coupled to antigenic MHC class I complexes induces specific growth inhibition and regression of established syngeneic tumor grafts.
Cancer immunity Aug, 2003 | Pubmed ID: 12916958
Medicinal application of long synthetic peptide technology.
Expert opinion on biological therapy Oct, 2004 | Pubmed ID: 15461574
Plasmodium falciparum merozoite surface protein 6 displays multiple targets for naturally occurring antibodies that mediate monocyte-dependent parasite killing.
Infection and immunity Feb, 2005 | Pubmed ID: 15664972
A strong CD8+ T cell response is elicited using the synthetic polypeptide from the C-terminus of the circumsporozoite protein of Plasmodium berghei together with the adjuvant QS-21: quantitative and phenotypic comparison with the vaccine model of irradiated sporozoites.
Vaccine Apr, 2005 | Pubmed ID: 15780728
Synthetic RGD-containing alpha-helical coiled coil peptides promote integrin-dependent cell adhesion.
Journal of peptide science : an official publication of the European Peptide Society Mar, 2006 | Pubmed ID: 16103993
A malaria vaccine that elicits in humans antibodies able to kill Plasmodium falciparum.
PLoS medicine Nov, 2005 | Pubmed ID: 16262450
Phase I malaria vaccine trial with a long synthetic peptide derived from the merozoite surface protein 3 antigen.
Infection and immunity Dec, 2005 | Pubmed ID: 16299295
Active antiviral T-lymphocyte response can be redirected against tumor cells by antitumor antibody x MHC/viral peptide conjugates.
Clinical cancer research : an official journal of the American Association for Cancer Research Dec, 2006 | Pubmed ID: 17189415
Peptide based malaria vaccine development: personal considerations.
Microbes and infection May, 2007 | Pubmed ID: 17398135
Plasmodium berghei-infected primary hepatocytes process and present the circumsporozoite protein to specific CD8+ T cells in vitro.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2007 | Pubmed ID: 17513754
Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif.
PloS one Jul, 2007 | Pubmed ID: 17653272
Protein structure based strategies for antigen discovery and vaccine development against malaria and other pathogens.
Endocrine, metabolic & immune disorders drug targets Dec, 2007 | Pubmed ID: 18220946
Sustained activation and tumor targeting of NKT cells using a CD1d-anti-HER2-scFv fusion protein induce antitumor effects in mice.
The Journal of clinical investigation Mar, 2008 | Pubmed ID: 18259610
Sporozoite-mediated hepatocyte wounding limits Plasmodium parasite development via MyD88-mediated NF-kappa B activation and inducible NO synthase expression.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2008 | Pubmed ID: 18322208
Longitudinal analyses of immune responses to Plasmodium falciparum derived peptides corresponding to novel blood stage antigens in coastal Kenya.
Vaccine Apr, 2008 | Pubmed ID: 18342997
Oxidative folding of synthetic polypeptides S-protected as tert-butylthio derivatives.
Journal of peptide science : an official publication of the European Peptide Society Dec, 2008 | Pubmed ID: 18781562
The N-terminal domain of Plasmodium falciparum circumsporozoite protein represents a target of protective immunity.
Vaccine Jan, 2009 | Pubmed ID: 18984024
Intranasal administration of the synthetic polypeptide from the C-terminus of the circumsporozoite protein of Plasmodium berghei with the modified heat-labile toxin of Escherichia coli (LTK63) induces a complete protection against malaria challenge.
Vaccine Feb, 2009 | Pubmed ID: 19111883
Evidence for multiple B- and T-cell epitopes in Plasmodium falciparum liver-stage antigen 3.
Infection and immunity Mar, 2009 | Pubmed ID: 19139199
The C-terminal domain of Plasmodium falciparum merozoite surface protein 3 self-assembles into alpha-helical coiled coil tetramer.
Molecular and biochemical parasitology Jun, 2009 | Pubmed ID: 19428662
Sequence conservation in Plasmodium falciparum alpha-helical coiled coil domains proposed for vaccine development.
PloS one May, 2009 | Pubmed ID: 19492090
Malarial hemozoin is a Nalp3 inflammasome activating danger signal.
PloS one Aug, 2009 | Pubmed ID: 19652710
The synthetic Plasmodium falciparum circumsporozoite peptide PfCS102 as a malaria vaccine candidate: a randomized controlled phase I trial.
PloS one Oct, 2009 | Pubmed ID: 19798415
Long synthetic peptides for the production of vaccines and drugs: a technological platform coming of age.
Science translational medicine Sep, 2010 | Pubmed ID: 20861510
Strain-transcending Fc-dependent killing of Plasmodium falciparum by merozoite surface protein 2 allele-specific human antibodies.
Infection and immunity Mar, 2011 | Pubmed ID: 21189324
The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host.
The Journal of experimental medicine Feb, 2011 | Pubmed ID: 21262960
Phase I safety and immunogenicity trial of Plasmodium vivax CS derived long synthetic peptides adjuvanted with montanide ISA 720 or montanide ISA 51.
The American journal of tropical medicine and hygiene Feb, 2011 | Pubmed ID: 21292873
Preclinical vaccine study of Plasmodium vivax circumsporozoite protein derived-synthetic polypeptides formulated in montanide ISA 720 and montanide ISA 51 adjuvants.
The American journal of tropical medicine and hygiene Feb, 2011 | Pubmed ID: 21292874
Antibody-mediated and cellular immune responses induced in naive volunteers by vaccination with long synthetic peptides derived from the Plasmodium vivax circumsporozoite protein.
The American journal of tropical medicine and hygiene Feb, 2011 | Pubmed ID: 21292876
Malaria vaccine candidate: design of a multivalent subunit α-helical coiled coil poly-epitope.
Vaccine Sep, 2011 | Pubmed ID: 21803099
Malaria vaccine development using synthetic peptides as a technical platform.
Advances in immunology , 2012 | Pubmed ID: 22449780
Cell biological characterization of the malaria vaccine candidate trophozoite exported protein 1.
PloS one , 2012 | Pubmed ID: 23056243
CSP--a model for in vivo presentation of Plasmodium berghei sporozoite antigens by hepatocytes.
PloS one , 2012 | Pubmed ID: 23272182
Novel birch pollen specific immunotherapy formulation based on contiguous overlapping peptides.
Clinical and translational allergy Jun, 2013 | Pubmed ID: 23725004
Antigenicity and immunogenicity of a novel chimeric peptide antigen based on the P. vivax circumsporozoite protein.
Vaccine Oct, 2013 | Pubmed ID: 23954378
Antigenicity and immunogenicity of a novel Plasmodium vivax circumsporozoite derived synthetic vaccine construct.
Vaccine May, 2014 | Pubmed ID: 24731811
Plasmodium vivax antigen discovery based on alpha-helical coiled coil protein motif.
PloS one , 2014 | Pubmed ID: 24959747
Priming of CD8(+) T Cell Responses to Liver Stage Malaria Parasite Antigens.
Frontiers in immunology , 2014 | Pubmed ID: 25414698
Plasmodium falciparum merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic domains.
Malaria journal Dec, 2014 | Pubmed ID: 25526742
Malaria Vaccines: Progressing on a Bumpy Road.
EBioMedicine Nov, 2014 | Pubmed ID: 26137504
Immunogenicity of dimorphic and C-terminal fragments of Plasmodium falciparum MSP2 formulated with different adjuvants in mice.
Vaccine Mar, 2016 | Pubmed ID: 26874325
Antibody levels against GLURP R2, MSP1 block 2 hybrid and AS202.11 and the risk of malaria in children living in hyperendemic (Burkina Faso) and hypo-endemic (Ghana) areas.
Malaria journal Feb, 2016 | Pubmed ID: 26921176
Natural immune response to Plasmodium vivax alpha-helical coiled coil protein motifs and its association with the risk of P. vivax malaria.
PloS one , 2017 | Pubmed ID: 28651021
The use of a P. falciparum specific coiled-coil domain to construct a self-assembling protein nanoparticle vaccine to prevent malaria.
Journal of nanobiotechnology Sep, 2017 | Pubmed ID: 28877692
A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein.
Nature medicine 05, 2018 | Pubmed ID: 29554084
The Candidate Blood-stage Malaria Vaccine P27A Induces a Robust Humoral Response in a Fast Track to the Field Phase 1 Trial in Exposed and Nonexposed Volunteers.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 01, 2019 | Pubmed ID: 29945169
Detection of antisense protein (ASP) RNA transcripts in individuals infected with human immunodeficiency virus type 1 (HIV-1).
The Journal of general virology May, 2019 | Pubmed ID: 30896385
Immunogenicity of a recombinant fusion construct composed of intrinsically unstructured, low polymorphic segments derived from merozoite surface protein 2 and trophozoite exported protein 1.
Vaccine Aug, 2019 | Pubmed ID: 31358409
Antonio Mancarella1,
Francesco A. Procopio1,
Tilmann Achsel2,
Elisa De Crignis3,
Brian T. Foley4,
Giampietro Corradin5,
Claudia Bagni2,
Giuseppe Pantaleo1,
Cecilia Graziosi1
1Division of Immunology and Allergy, Lausanne University Hospital,
2Department of Fundamental Neuroscience, University of Lausanne,
3Department of Biochemistry, Erasmus Medical Center,
4Theoretical Biology and Biophysics Group, Los Alamos National Laboratories,
5Department of Biochemistry, University of Lausanne
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