Department of Respiratory Medicine and Clinical Immunology
Shohei Koyama received his Ph.D. degree from Tohoku University, Japan.
As a post-doctoral fellow (2010 to 2015) in Glenn Dranoff’s lab at Dana-Farber Cancer Institute(DFCI), USA, he studied how the mutation of driver oncogenes and tumor-suppressor genes modulate the immune profile in lung cancer microenvironment using transgenic models and clinical samples in collaboration with Kwok-kin Wong`s lab and Peter Hammerman`s lab at DFCI.
He then moved to Atsushi Kumanogoh’s lab at Osaka University, Japan, as assistant professor. His research focus on the role of guidance molecules in lung cancer microenvironment.
Clarifying the biological significance of the CHK2 K373E somatic mutation discovered in The Cancer Genome Atlas database.
FEBS letters Dec, 2016 | Pubmed ID: 27716909
Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis.
Annals of the rheumatic diseases Aug, 2017 | Pubmed ID: 28416516
Interleukin-17A Promotes Lung Tumor Progression through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 08, 2017 | Pubmed ID: 28483607
Trastuzumab emtansine suppresses the growth of HER2-positive small-cell lung cancer in preclinical models.
Biochemical and biophysical research communications 07, 2017 | Pubmed ID: 28526406
Immunophenotyping of pediatric brain tumors: correlating immune infiltrate with histology, mutational load, and survival and assessing clonal T cell response.
Journal of neuro-oncology Apr, 2018 | Pubmed ID: 29322427
Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging.
Scientific reports 03, 2018 | Pubmed ID: 29572511
Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses.
Nature medicine 08, 2018 | Pubmed ID: 30038220
[A Case of Mediastinal Small Cell Lung Cancer in a Patient Receiving Mechanical Ventilation Who Was Successfully Treated with Chemotherapy and Finally Extubated].
Gan to kagaku ryoho. Cancer & chemotherapy Sep, 2018 | Pubmed ID: 30237376
Eosinophil-derived neurotoxin enhances airway remodeling in eosinophilic chronic rhinosinusitis and correlates with disease severity.
International immunology 02, 2019 | Pubmed ID: 30239772
Clinical implications of monitoring nivolumab immunokinetics in non-small cell lung cancer patients.
JCI insight 10, 2018 | Pubmed ID: 30282824
SEMA4A promotes eosinophil survival and contributes to eosinophil-mediated allergic diseases.
Allergology international : official journal of the Japanese Society of Allergology Apr, 2019 | Pubmed ID: 30342889
Semaphorin 7A promotes EGFR-TKI resistance in EGFR mutant lung adenocarcinoma cells.
JCI insight 12, 2018 | Pubmed ID: 30568033
A lung abscess caused by secondary syphilis - the utility of polymerase chain reaction techniques in transbronchial biopsy: a case report.
BMC infectious diseases Jul, 2019 | Pubmed ID: 31288744
Monitoring antibody binding to T cells in a pembrolizumab-treated patient with lung adenocarcinoma on hemodialysis.
Thoracic cancer Nov, 2019 | Pubmed ID: 31520515
Severe myocarditis with slight lymphocytic infiltration after nivolumab treatment.
Lung cancer (Amsterdam, Netherlands) Feb, 2020 | Pubmed ID: 31848027
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