Maureen Gannon

PDX:PBX complexes are required for normal proliferation of pancreatic cells during development.

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas.

Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6.

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors.

The role of pdx1 and HNF6 in proliferation and differentiation of endocrine precursors.

Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets.

The proximal islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen promoter is sufficient to initiate but not maintain transgene expression in mouse islets in vivo.

Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase.

Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.

The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass.

Characterization of diabetic nephropathy in a transgenic model of hypoinsulinemic diabetes.

Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression.

Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function.

Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells.

Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion.

BuMP-ing up insulin secretion by pancreatic beta cells.

Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression.

Deficiency of endothelial nitric-oxide synthase confers susceptibility to diabetic nephropathy in nephropathy-resistant inbred mice.

pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis.

Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis.

Beta-cell proliferation, but not neogenesis, following 60% partial pancreatectomy is impaired in the absence of FoxM1.

Regulation of pancreas plasticity and malignant transformation by Akt signaling.

Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis.

Bioluminescence imaging in mouse models quantifies beta cell mass in the pancreas and after islet transplantation.

Pancreas cell fate.

Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation.

Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen.

Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling.

OASIS/CREB3L1 induces expression of genes involved in extracellular matrix production but not classical endoplasmic reticulum stress response genes in pancreatic beta-cells.

Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.

Diet-induced impaired glucose tolerance and gestational diabetes in the dog.

Type 2 diabetes and the aging pancreatic beta cell.

Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells.

Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo.

Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice.

Differential regulation of embryonic and adult β cell replication.

Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function.

The skeletal site-specific role of connective tissue growth factor in prenatal osteogenesis.

A physiological role for connective tissue growth factor in early wound healing.

Onecut1 is essential for horizontal cell genesis and retinal integrity.

Advancements and challenges in generating accurate animal models of gestational diabetes mellitus.

Connective tissue growth factor (CTGF/CCN2) negatively regulates BMP-2 induced osteoblast differentiation and signaling.

An assay for small scale screening of candidate β cell proliferative factors using intact islets.

Loss of HNF6 expression correlates with human pancreatic cancer progression.

Activated FoxM1 attenuates streptozotocin-mediated β-cell death.

Connective tissue growth factor modulates adult β-cell maturity and proliferation to promote β-cell regeneration in mice.

High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice.

Preserving Mafa expression in diabetic islet β-cells improves glycemic control in vivo.

Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion.

Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury.

The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice.

Sustained expression of GLP-1 receptor differentially modulates β-cell functions in diabetic and nondiabetic mice.

Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation in Mice.

Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function.

Loss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival.

HNF6 and Rev-erbα integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms.

Connective tissue growth factor is critical for proper β-cell function and pregnancy-induced β-cell hyperplasia in adult mice.

Unexpected effects of the MIP-CreER transgene and tamoxifen on β-cell growth in C57Bl6/J male mice.

Growth Hormone Mediates Its Protective Effect in Hepatic Apoptosis through Hnf6.

Onecut transcription factors in development and disease.

Regulation of pancreatic β-cell function and mass dynamics by prostaglandin signaling.

Opposing effects of prostaglandin E receptors EP3 and EP4 on mouse and human β-cell survival and proliferation.

Gestational diabetes exacerbates maternal immune activation effects in the developing brain.

Vascular-derived connective tissue growth factor (Ctgf) is critical for pregnancy-induced β cell hyperplasia in adult mice.

The liver.

Cooperative function of Pdx1 and Oc1 in multipotent pancreatic progenitors impacts postnatal islet maturation and adaptability.

Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca Sensitivity of Insulin Secretion Vesicles.

Developmental programming of the pancreatic islet by overnutrition.

Sex differences underlying pancreatic islet biology and its dysfunction.

Increases in bioactive lipids accompany early metabolic changes associated with β-cell expansion in response to short-term high-fat diet.

A call for improved reporting of human islet characteristics in research articles.

A Call for Improved Reporting of Human Islet Characteristics in Research Articles.

Regulation of the Pancreatic Exocrine Differentiation Program and Morphogenesis by Onecut 1/Hnf6.

Sex modifies placental gene expression in response to metabolic and inflammatory stress.

Maternal Western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition.

Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity.

Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates Tumorigenesis.

Extracellular matrix-associated factors play critical roles in regulating pancreatic β-cell proliferation and survival.

Differential cell susceptibilities to Kras in the setting of obstructive chronic pancreatitis.

The Beta Cell in Type 2 Diabetes.

Ins1-Cre and Ins1-CreER Gene Replacement Alleles Are Susceptible To Silencing By DNA Hypermethylation.

Maternal Obesity and Western-Style Diet Impair Fetal and Juvenile Offspring Skeletal Muscle Insulin-Stimulated Glucose Transport in Nonhuman Primates.

Unexpected effects of ivermectin and selamectin on inducible Cre activity in mice.

Cell Cycle Regulation of the Pdx1 Transcription Factor in Developing Pancreas and Insulin-Producing β-Cells.

Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease.

Micro-RNA-mediated Maintenance of Beta-cell Identity Reveals Targets for Reversing Beta-cell Dedifferentiation.

Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent.

Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model.

The Tetracycline-Controlled Transactivator (Tet-On/Off) System in β-Cells Reduces Insulin Expression and Secretion in Mice.

Pharmacological blockade of the EP3 prostaglandin E receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage.

Maternal Western diet exposure increases periportal fibrosis beginning in utero in nonhuman primate offspring.

Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent.

Pharmacological modulation of prostaglandin E (PGE ) EP receptors improves cardiomyocyte function under hyperglycemic conditions.

Effects of Arachidonic Acid and Its Metabolites on Functional Beta-Cell Mass.

NR5A2/LRH-1 regulates the PTGS2-PGE-PTGER1 pathway contributing to pancreatic islet survival and function.

Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes.

Macrophages and neutrophils are necessary for ER stress-induced β cell loss.

Developmental effects of metformin exposure.

Maternal Western diet is associated with distinct preclinical pediatric NAFLD phenotypes in juvenile nonhuman primate offspring.

Harnessing prostaglandin E signaling to ameliorate autoimmunity.

Maternal diet alters long-term innate immune cell memory in fetal and juvenile hematopoietic stem and progenitor cells in nonhuman primate offspring.

Maternal Western-style diet in nonhuman primates leads to offspring islet adaptations including altered gene expression and insulin hypersecretion.

Context-dependent effects of CCN2 on β-cell mass expansion and indicators of cell stress in the setting of acute and chronic stress.

A Maternal Western-Style Diet Impairs Skeletal Muscle Lipid Metabolism in Adolescent Japanese Macaques.

Studies of Rare Human Diseases Lead to Insights into Regulation of Human Beta-cell Proliferation.

The prostaglandin E EP3 receptor has disparate effects on islet insulin secretion and content in β-cells in a high-fat diet-induced mouse model of obesity.

Initiation of metformin in early pregnancy results in fetal bioaccumulation, growth restriction, and renal dysmorphology in a primate model.

Epigenetic modulation of cell fate during pancreas development.

Analysis of beta-cell maturity and mitochondrial morphology in juvenile non-human primates exposed to maternal Western-style diet during development.

A Developmental Approach to Mid-Career Faculty Leadership Training at Two Academic Medical Centers.

CUTting through the distance: A disease-relevant long-range ONECUT1 enhancer.