Jean-François Tanti did his PhD in the laboratory of the Professor Emmanuel Van Obberghen in Nice (France) under the supervision of the Doctor Yannick Le Marchand-Brustel where he studied the role of PKC and cAMP dependent kinase in the modulation of the insulin signaling and metabolic effects. In 1990, he obtained a tenured position in CNRS (Centre National de la Recherche Scientifique) to work on the insulin signaling pathways involved in glucose transport. In 2003, he moved to the new laboratory of Dr Y Le Marchand-Brustel focusing mainly on the posttranslational modifications of insulin receptor substrate and the role of different serine kinases in the development of insulin resistance. In 2007, he became a group leader in the Mediterranean Research Center for Molecular Medicine where his team « Cellular and Molecular Pathophysiology of Obesity and Diabetes" focuses on three related and highly integrated areas which are central to obesity-associated insulin resistance and T2D development : 1) mechanisms of insulin signaling and glucose transport in adipocytes and how they are altered in insulin resistant state 2) identification of stress-signaling pathways involved in adipose tissue inflammation and dysfunction 3) identification of new players controlling hepatic gluconeogenesis.He is also the deputy director of the C3M Institute. He is author of 101 original articles or reviews in peer-reviewed journals.
