Inna Smalley
Department of Cancer Physiology
H. Lee Moffitt Cancer Center & Research Institute
With over 12 years of experience studying melanoma biology, my research has largely focused on developing novel therapeutic rationales for treating BRAF- and NRAS-mutant melanoma, with an emphasis on the role of the tumor microenvironment in drug resistance. My previous work was dedicated to delineating the mechanisms of drug resistance in BRAF-mutant melanoma that rely on extracellular matrix remodeling and fibroblast activation. My most recent efforts are focused on exploring how intra-tumoral heterogeneity facilitates tumor growth, drug resistance and dissemination, with a special focus on single cell analysis techniques and metabolism-associated signaling. I would like to elucidate what drives tumor cells to certain metastatic sites, including the brain and leptomeninges, as well as the mechanism supporting their survival in different microenvironments. I believe that the future treatment of melanoma lies in personalized, rational drug combinations that will turn a terminal disease into a manageable chronic illness. My career goal is to develop efficacious treatment strategies for patients with CNS metastasis and late-stage disease.
Noncanonical EphA2 Signaling Is a Driver of Tumor-Endothelial Cell Interactions and Metastatic Dissemination in BRAF Inhibitor‒Resistant Melanoma.
The Journal of investigative dermatology Sep, 2020 | Pubmed ID: 32890629
Single-Cell Characterization of the Immune Microenvironment of Melanoma Brain and Leptomeningeal Metastases.
Clinical cancer research : an official journal of the American Association for Cancer Research Jul, 2021 | Pubmed ID: 34035069
A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease
Vincent Law1,2,
Margi Baldwin3,
Ganesan Ramamoorthi4,
Krithika Kodumudi4,
Nam Tran1,
Inna Smalley5,
Derek Duckett6,
Pawel Kalinski7,
Brian Czerniecki4,
Keiran S. M. Smalley2,
Peter A. Forsyth1,2
1Department of Neuro-Oncology, H. Lee Moffitt Cancer Center & Research Institute,
2Department of Tumor Biology, H. Lee Moffitt Cancer Center & Research Institute,
3Department of Comparative Medicine, University of South Florida,
4Department of Breast Oncology, H. Lee Moffitt Cancer Center & Research Institute,
5Department of Cancer Physiology, H. Lee Moffitt Cancer Center & Research Institute,
6Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute,
7Department of Medical Oncology, Roswell Park Comprehensive Cancer Center
Ex Vivo Culture of Circulating Tumor Cells in the Cerebral Spinal Fluid from Melanoma Patients to Study Melanoma-Associated Leptomeningeal Disease
Vincent Law1,2,
Inna Smalley3,
Brittany R. Evernden2,
Margaret Baldwin4,
Keiran S. M. Smalley1,
Peter A. Forsyth1,2
1Department of Tumor Biology, University of South Florida, H. Lee Moffitt Cancer Center & Research Institute,
2Department of Neuro-Oncology, University of South Florida, H. Lee Moffitt Cancer Center & Research Institute,
3Department of Cancer Physiology, University of South Florida, H. Lee Moffitt Cancer Center & Research Institute,
4Department of Comparative Medicine, University of South Florida, H. Lee Moffitt Cancer Center & Research Institute
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