Department of General Pediatrics,
Neonatology and Pediatric Cardiology,
Duesseldorf University Hospital,
Medical Faculty,
Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty
Alessandro Prigione is a tenured Associate Professor of Pediatric Metabolic Medicine at the Department of General Pediatrics, Neonatology and Pediatric Cardiology at Heinrich Heine University (HHU) in Düsseldorf Germany.
The interest of the Prigione group is to develop induced pluripotent stem cells (iPSC)-based approaches for disease modeling and drug discovery of rare incurable neurological and neurodevelopmental disorders affecting mitochondrial metabolism. A specific focus is on Leigh syndrome, which is the most severe mitochondrial disease affecting children. His laboratory employs human neurons and brain organoids from patients with Leigh syndrome to dissect the neuronal-specific disease mechanisms to possibly identify novel disease targets and interventions.
Transcriptome based identification of mouse cumulus cell markers that predict the developmental competence of their enclosed antral oocytes.
BMC genomics , 2013 | Pubmed ID: 23758669
A mitochondrial strategy for safeguarding the reprogrammed genome.
Cell regeneration (London, England) , 2014 | Pubmed ID: 25408884
Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks.
BMC genomics Feb, 2015 | Pubmed ID: 25765079
Erratum: Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks.
BMC genomics Jun, 2015 | Pubmed ID: 26048372
Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders.
Cell stem cell 05, 2017 | Pubmed ID: 28132834
Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis.
Glia 01, 2018 | Pubmed ID: 28940767
Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery.
Redox biology 05, 2020 | Pubmed ID: 32145456
Tackling mitochondrial diversity in brain function: from animal models to human brain organoids.
The international journal of biochemistry & cell biology 06, 2020 | Pubmed ID: 32339638
PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification.
The Journal of experimental medicine 10, 2020 | Pubmed ID: 32609329
Biocompatibility of α-AlO Ceramic Substrates with Human Neural Precursor Cells.
Journal of functional biomaterials Sep, 2020 | Pubmed ID: 32947990
Therapeutic Approaches to Treat Mitochondrial Diseases: "One-Size-Fits-All" and "Precision Medicine" Strategies.
Pharmaceutics Nov, 2020 | Pubmed ID: 33187380
Assessment of Ethanol-Induced Toxicity on iPSC-Derived Human Neurons Using a Novel High-Throughput Mitochondrial Neuronal Health (MNH) Assay.
Frontiers in cell and developmental biology , 2020 | Pubmed ID: 33224955
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.
Nature communications 03, 2021 | Pubmed ID: 33771987
Generation of Human iPSC-derived Neural Progenitor Cells (NPCs) as Drug Discovery Model for Neurological and Mitochondrial Disorders.
Bio-protocol Mar, 2021 | Pubmed ID: 33796613
Bioenergetic Profiling of Human Pluripotent Stem Cells.
Methods in molecular biology (Clifton, N.J.) , 2021 | Pubmed ID: 34080164
Mitochondria in neurogenesis: Implications for mitochondrial diseases.
Stem cells (Dayton, Ohio) Jun, 2021 | Pubmed ID: 34089537
Stephanie Le1,
Laura Petersilie2,
Gizem Inak1,4,
Carmen Menacho-Pando1,
Karl W. Kafitz2,
Agnieszka Rybak-Wolf3,
Nikolaus Rajewsky3,
Christine R. Rose2,
Alessandro Prigione1,5
1Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty, Heinrich Heine University,
2Institute of Neurobiology, Heinrich Heine University,
3Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrueck Center for Molecular Medicine (MDC),
4Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai,
5, Max Delbrueck Center for Molecular Medicine (MDC)
JoVE 소개
Copyright © 2024 MyJoVE Corporation. 판권 소유