Newcastle Fibrosis Research Group,
BioSciences Institute,
Faculty of Medical Sciences,
Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences
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NF-kappaB is a critical regulator of the survival of rodent and human hepatic myofibroblasts.
Journal of hepatology Apr, 2008 | Pubmed ID: 18279996
Nuclear factor-kappaB1: regulation and function.
The international journal of biochemistry & cell biology , 2008 | Pubmed ID: 17693123
Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis.
Gastroenterology Jun, 2009 | Pubmed ID: 19303015
MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis.
Gastroenterology Feb, 2010 | Pubmed ID: 19843474
The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation.
Hepatology (Baltimore, Md.) Mar, 2010 | Pubmed ID: 20058312
The NF-kappaB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes.
Journal of hepatology Sep, 2010 | Pubmed ID: 20579762
BAG-1 interacts with the p50-p50 homodimeric NF-κB complex: implications for colorectal carcinogenesis.
Oncogene May, 2012 | Pubmed ID: 21963853
Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease.
Nature medicine Nov, 2011 | Pubmed ID: 22120177
The NF-κB subunit c-Rel stimulates cardiac hypertrophy and fibrosis.
The American journal of pathology Mar, 2012 | Pubmed ID: 22210479
Roles of c-Rel signalling in inflammation and disease.
The international journal of biochemistry & cell biology Jun, 2012 | Pubmed ID: 22405852
Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation.
Hepatology (Baltimore, Md.) Sep, 2012 | Pubmed ID: 22488473
Mechanisms and biomarkers of apoptosis in liver disease and fibrosis.
International journal of hepatology , 2012 | Pubmed ID: 22567408
Multigenerational epigenetic adaptation of the hepatic wound-healing response.
Nature medicine Sep, 2012 | Pubmed ID: 22941276
Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response.
Hepatology (Baltimore, Md.) Feb, 2013 | Pubmed ID: 22996371
Serotonin paracrine signaling in tissue fibrosis.
Biochimica et biophysica acta Jul, 2013 | Pubmed ID: 23032152
Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells in mice.
Hepatology (Baltimore, Md.) Mar, 2013 | Pubmed ID: 23080298
The c-Rel subunit of NF-κB regulates epidermal homeostasis and promotes skin fibrosis in mice.
The American journal of pathology Jun, 2013 | Pubmed ID: 23562440
Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies.
Toxicological sciences : an official journal of the Society of Toxicology Feb, 2014 | Pubmed ID: 24235770
Noninvasive in vivo magnetic resonance measures of glutathione synthesis in human and rat liver as an oxidative stress biomarker.
Hepatology (Baltimore, Md.) Jun, 2014 | Pubmed ID: 24242936
A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse.
Journal of hepatology Apr, 2014 | Pubmed ID: 24333183
Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3.
PloS one , 2014 | Pubmed ID: 24416163
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.
Nature communications Jun, 2014 | Pubmed ID: 24960204
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease.
Journal of hepatology Dec, 2015 | Pubmed ID: 26264933
Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation.
PloS one , 2015 | Pubmed ID: 26302150
Histone Demethylation and Toll-like Receptor 8-Dependent Cross-Talk in Monocytes Promotes Transdifferentiation of Fibroblasts in Systemic Sclerosis Via Fra-2.
Arthritis & rheumatology (Hoboken, N.J.) 06, 2016 | Pubmed ID: 26814616
Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease.
Scientific reports Feb, 2016 | Pubmed ID: 26831567
Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum.
Annual review of pathology 05, 2016 | Pubmed ID: 26980160
TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury.
Journal of immunology (Baltimore, Md. : 1950) 05, 2016 | Pubmed ID: 27053764
A new fluorescence-based optical imaging method to non-invasively monitor hepatic myofibroblasts in vivo.
Journal of hepatology 07, 2016 | Pubmed ID: 27067455
A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A.
Molecular therapy : the journal of the American Society of Gene Therapy 01, 2017 | Pubmed ID: 28129116
The NF-κB1 is a key regulator of acute but not chronic renal injury.
Cell death & disease 06, 2017 | Pubmed ID: 28617440
Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage.
Gut Jan, 2018 | Pubmed ID: 29374630
The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis.
Hepatology communications 08, 2017 | Pubmed ID: 29404476
Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway.
Nucleic acids research 07, 2018 | Pubmed ID: 29873780
Rapamycin improves healthspan but not inflammaging in nfκb1 mice.
Aging cell 02, 2019 | Pubmed ID: 30468013
Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 04, 2019 | Pubmed ID: 30608881
Enhanced in vivo Optical Imaging of the Inflammatory Response to Acute Liver Injury in C57BL/6 Mice Using a Highly Bright Near-Infrared BODIPY Dye.
ChemMedChem 05, 2019 | Pubmed ID: 30920173
A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision-Cut Liver Slices.
Hepatology (Baltimore, Md.) 10, 2019 | Pubmed ID: 30963615
Sinusoidal and pericellular fibrosis in adult post-transplant liver biopsies: association with hepatic stellate cell activation and patient outcome.
Virchows Archiv : an international journal of pathology Aug, 2019 | Pubmed ID: 31201503
Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells.
Gastroenterology 11, 2019 | Pubmed ID: 31352003
Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease.
Hepatology (Baltimore, Md.) 03, 2020 | Pubmed ID: 31378982
Editorial overview: Fibrosis.
Current opinion in pharmacology 12, 2019 | Pubmed ID: 31699602
Implementation of pre-clinical methodologies to study fibrosis and test anti-fibrotic therapy.
Current opinion in pharmacology 12, 2019 | Pubmed ID: 31731225
Loss of ELK1 has differential effects on age-dependent organ fibrosis.
The international journal of biochemistry & cell biology 03, 2020 | Pubmed ID: 31877385
FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis.
JCI insight 02, 2020 | Pubmed ID: 32102985
Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis.
Gut 02, 2021 | Pubmed ID: 32327527
Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma.
Hepatology (Baltimore, Md.) 03, 2021 | Pubmed ID: 32460431
Long noncoding RNA H19X is a key mediator of TGF-β-driven fibrosis.
The Journal of clinical investigation 09, 2020 | Pubmed ID: 32603313
Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse.
Ecotoxicology and environmental safety Oct, 2020 | Pubmed ID: 32634706
Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis.
Nature metabolism 06, 2020 | Pubmed ID: 32694734
cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis.
Rheumatology (Oxford, England) 12, 2020 | Pubmed ID: 32725139
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms.
Gut Jul, 2021 | Pubmed ID: 32907830
Anti-inflammatory treatment rescues memory deficits during aging in nfkb1 mice.
Aging cell 10, 2020 | Pubmed ID: 32915495
Age-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis.
Nature cancer Oct, 2020 | Pubmed ID: 33073241
c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis.
Nature metabolism 11, 2020 | Pubmed ID: 33168981
RNA sequencing reveals changes in the microRNAome of transdifferentiating hepatic stellate cells that are conserved between human and rat.
Scientific reports 12, 2020 | Pubmed ID: 33303921
Author Correction: c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis.
Nature metabolism Jan, 2021 | Pubmed ID: 33303984
Non-invasive synchronous monitoring of neutrophil migration using whole body near-infrared fluorescence-based imaging.
Scientific reports 01, 2021 | Pubmed ID: 33446811
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression.
Molecular metabolism 06, 2021 | Pubmed ID: 33722690
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.
The EMBO journal May, 2021 | Pubmed ID: 33764576
A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis.
Hepatology (Baltimore, Md.) Jul, 2021 | Pubmed ID: 34233024
Key features of the environment promoting liver cancer in the absence of cirrhosis.
Scientific reports Aug, 2021 | Pubmed ID: 34408183
Marco Y. W. Zaki*,1,2,
Shishir Shetty*,2,
Alex L. Wilkinson2,
Daniel A. Patten2,
Fiona Oakley*,3,
Helen Reeves*,4,5
1Department of Biochemistry, Faculty of Pharmacy, Minia University,
2National Institute for Health Research Birmingham Liver Biomedical Research Unit and Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham,
3Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University,
4Newcastle University Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University,
5The Liver Unit, Department of Medicine, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust
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