Integrated Physiology and Molecular Medicine Laboratory
Christopher Axelrod is the director of the Integrative Physiology and Molecular Medicine laboratory at Pennington Biomedical Research Center in Baton Rouge, Louisiana. His research applies a bioenergetic lens to understanding the pathogenesis and treatment of complex metabolic diseases such as insulin resistance, obesity, type 2 diabetes, non-alcoholic fatty liver disease, and cancer. Research interests include the development and testing of mitochondrial targeted pharmacotherapies, redox homeostasis in aging and disease, and therapeutic applications of metabolic surgery.
Mitochondrial dynamics in skeletal muscle insulin resistance and type 2 diabetes.
Translational research : the journal of laboratory and clinical medicine 12, 2018 | Pubmed ID: 30153426
Exercise training remodels human skeletal muscle mitochondrial fission and fusion machinery towards a pro-elongation phenotype.
Acta physiologica (Oxford, England) 04, 2019 | Pubmed ID: 30408342
Gastric Bypass Surgery Improves the Skeletal Muscle Ceramide/S1P Ratio and Upregulates the AMPK/ SIRT1/ PGC-1α Pathway in Zucker Diabetic Fatty Rats.
Obesity surgery 07, 2019 | Pubmed ID: 30809769
UCC118 supplementation reduces exercise-induced gastrointestinal permeability and remodels the gut microbiome in healthy humans.
Physiological reports 11, 2019 | Pubmed ID: 31758610
Exercise Training Rapidly Increases Hepatic Insulin Extraction in NAFLD.
Medicine and science in sports and exercise 07, 2020 | Pubmed ID: 32028458
Lipids and ketones dominate metabolism at the expense of glucose control in pulmonary arterial hypertension: a hyperglycaemic clamp and metabolomics study.
The European respiratory journal 04, 2020 | Pubmed ID: 32108049
β-Hydroxybutyrate is reduced in humans with obesity-related NAFLD and displays a dose-dependent effect on skeletal muscle mitochondrial respiration in vitro.
American journal of physiology. Endocrinology and metabolism 07, 2020 | Pubmed ID: 32396388
Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling.
Diabetes 08, 2020 | Pubmed ID: 32409493
BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control.
EMBO molecular medicine 07, 2020 | Pubmed ID: 32519812
Roux-en-Y Gastric Bypass Restores Islet Function and Morphology Independent of Body Weight in ZDF Rats.
American journal of physiology. Endocrinology and metabolism Jan, 2021 | Pubmed ID: 33427046
Foregut Exclusion Enhances Incretin and Insulin Secretion After Roux-en-Y Gastric Bypass in Adults with Type 2 Diabetes.
The Journal of clinical endocrinology and metabolism Apr, 2021 | Pubmed ID: 33870426
Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans.
Metabolism: clinical and experimental Aug, 2021 | Pubmed ID: 34090870
CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases.
Disease models & mechanisms Jul, 2021 | Pubmed ID: 34160014
CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases.
Disease models & mechanisms Jul, 2021 | Pubmed ID: 34296742
1Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center,
2Clinical Oncology and Metabolism, Pennington Biomedical Research Center,
3Department of Nutrition, Case Western Reserve University,
4Department of Clinical Nutrition, University of Texas Southwestern Medical Center
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