Department of Physiology and Cell Biology
Brandon J. Biesiadecki has not added Biography.
If you are Brandon J. Biesiadecki and would like to personalize this page please email our Author Liaison for assistance.
Increased phosphorylation of tropomyosin, troponin I, and myosin light chain-2 after stretch in rabbit ventricular myocardium under physiological conditions.
Journal of molecular and cellular cardiology May, 2010 | Pubmed ID: 20298699
A high-throughput solid-phase microplate protein-binding assay to investigate interactions between myofilament proteins.
Journal of biomedicine & biotechnology , 2011 | Pubmed ID: 22190850
Effects of increased preload on the force-frequency response and contractile kinetics in early stages of cardiac muscle hypertrophy.
American journal of physiology. Heart and circulatory physiology Jun, 2012 | Pubmed ID: 22467304
AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function.
The Journal of biological chemistry Jun, 2012 | Pubmed ID: 22493448
Engineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity.
The Journal of biological chemistry Jun, 2012 | Pubmed ID: 22511780
Staurosporine inhibits frequency-dependent myofilament desensitization in intact rabbit cardiac trabeculae.
Biochemistry research international , 2012 | Pubmed ID: 22649731
The rates of Ca2+ dissociation and cross-bridge detachment from ventricular myofibrils as reported by a fluorescent cardiac troponin C.
The Journal of biological chemistry Aug, 2012 | Pubmed ID: 22718768
Advanced glycation end product cross-link breaker attenuates diabetes-induced cardiac dysfunction by improving sarcoplasmic reticulum calcium handling.
Frontiers in physiology , 2012 | Pubmed ID: 22934044
Effects of increased systolic Ca(2+) and β-adrenergic stimulation on Ca(2+) transient decline in NOS1 knockout cardiac myocytes.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society Dec, 2012 | Pubmed ID: 22960389
Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation.
Archives of biochemistry and biophysics Jul, 2013 | Pubmed ID: 23232082
Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides.
Cardiovascular research Jan, 2014 | Pubmed ID: 24104877
Protein kinase C phosphomimetics alter thin filament Ca2+ binding properties.
PloS one , 2014 | Pubmed ID: 24466001
Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins.
Circulation. Cardiovascular genetics Apr, 2014 | Pubmed ID: 24585742
Combined troponin I Ser-150 and Ser-23/24 phosphorylation sustains thin filament Ca(2+) sensitivity and accelerates deactivation in an acidic environment.
Journal of molecular and cellular cardiology Jul, 2014 | Pubmed ID: 24657721
Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed by novel dual-sided intramural optical mapping.
Circulation Jul, 2014 | Pubmed ID: 24838362
Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation.
Journal of molecular and cellular cardiology Nov, 2014 | Pubmed ID: 25252176
Obligatory role of neuronal nitric oxide synthase in the heart's antioxidant adaptation with exercise.
Journal of molecular and cellular cardiology Apr, 2015 | Pubmed ID: 25595735
Dissociation of Calcium Transients and Force Development following a Change in Stimulation Frequency in Isolated Rabbit Myocardium.
BioMed research international , 2015 | Pubmed ID: 25961020
Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart.
Science signaling , | Pubmed ID: 26198358
Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart.
Circulation. Arrhythmia and electrophysiology Oct, 2015 | Pubmed ID: 26304511
Nucleotide and protein sequences for dog masticatory tropomyosin identify a novel Tpm4 gene product.
Journal of muscle research and cell motility Oct, 2015 | Pubmed ID: 26400443
Should we treat heart failure with phosphatase inhibitors? Better to start at the end.
Journal of molecular and cellular cardiology Dec, 2015 | Pubmed ID: 26497613
Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease.
Nature communications Feb, 2016 | Pubmed ID: 26908229
Myofilament modulation of contraction.
Archives of biochemistry and biophysics 07, 2016 | Pubmed ID: 27156968
The Need for Speed: Mice, Men, and Myocardial Kinetic Reserve.
Circulation research 07, 2016 | Pubmed ID: 27458197
Adenosine-Induced Atrial Fibrillation: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart.
Circulation Aug, 2016 | Pubmed ID: 27462069
Myofilament Calcium Sensitivity: Role in Regulation of Cardiac Contraction and Relaxation.
Frontiers in physiology , 2016 | Pubmed ID: 28018228
Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I.
Frontiers in physiology , 2016 | Pubmed ID: 28066265
Tri-modal regulation of cardiac muscle relaxation; intracellular calcium decline, thin filament deactivation, and cross-bridge cycling kinetics.
Biophysical reviews Dec, 2014 | Pubmed ID: 28510030
Functional communication between PKC-targeted cardiac troponin I phosphorylation sites.
Archives of biochemistry and biophysics 08, 2017 | Pubmed ID: 28587770
Secondary phosphorylation in myocytes expressing FLAG-tagged and non-tagged phospho-mimetic cardiac troponin I.
Data in brief Dec, 2017 | Pubmed ID: 29071293
Assessment of PKA and PKC inhibitors on force and kinetics of non-failing and failing human myocardium.
Life sciences Dec, 2018 | Pubmed ID: 30399377
3-Chlorodiphenylamine activates cardiac troponin by a mechanism distinct from bepridil or TFP.
The Journal of general physiology 01, 2019 | Pubmed ID: 30442775
Troponin I modulation of cardiac performance: Plasticity in the survival switch.
Archives of biochemistry and biophysics 03, 2019 | Pubmed ID: 30684464
Current and Future Directions of Myofilament Regulation.
Archives of biochemistry and biophysics 05, 2019 | Pubmed ID: 31051122
Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node.
Nature communications 01, 2020 | Pubmed ID: 31980605
Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity.
Journal of molecular and cellular cardiology 02, 2020 | Pubmed ID: 31981571
mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction.
Proceedings of the National Academy of Sciences of the United States of America 08, 2020 | Pubmed ID: 32690703
Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles.
JACC. Basic to translational science Aug, 2020 | Pubmed ID: 32875169
Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts.
eLife 05, 2022 | Pubmed ID: 35502901
JoVE 소개
Copyright © 2024 MyJoVE Corporation. 판권 소유