Brain Research Institute,
Molecular Biology Institute,
Department of Neurology,
Brain Research Institute, Molecular Biology Institute
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Building Units for N-Backbone Cyclic Peptides. 3. Synthesis of Protected N(alpha)-(omega-Aminoalkyl)amino Acids and N(alpha)-(omega-Carboxyalkyl)amino Acids.
The Journal of organic chemistry Jan, 1997 | Pubmed ID: 11671417
Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies.
Journal of neuroscience research Sep, 2002 | Pubmed ID: 12210822
Polyglutamine repeat length-dependent proteolysis of huntingtin.
Neurobiology of disease Oct, 2002 | Pubmed ID: 12460551
Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2003 | Pubmed ID: 12506200
Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization.
The Journal of biological chemistry Sep, 2003 | Pubmed ID: 12840029
Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease.
The Journal of clinical investigation Aug, 2003 | Pubmed ID: 12897209
A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization.
Journal of the American Chemical Society Dec, 2003 | Pubmed ID: 14664580
Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies.
Accounts of chemical research Jun, 2004 | Pubmed ID: 15196045
Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform.
Journal of the American Chemical Society Feb, 2005 | Pubmed ID: 15713083
Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays.
Methods in molecular biology (Clifton, N.J.) , 2005 | Pubmed ID: 15980591
Determination of Peptide oligomerization state using rapid photochemical crosslinking.
Methods in molecular biology (Clifton, N.J.) , 2005 | Pubmed ID: 15980592
Neurotoxic protein oligomers--what you see is not always what you get.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis Jun, 2005 | Pubmed ID: 16011984
En route to early diagnosis of Alzheimer's disease--are we there yet?
Trends in biotechnology Nov, 2005 | Pubmed ID: 16165236
Amyloid beta-protein monomer structure: a computational and experimental study.
Protein science : a publication of the Protein Society Mar, 2006 | Pubmed ID: 16501222
Dendrimeric Abeta1-15 is an effective immunogen in wildtype and APP-tg mice.
Neurobiology of aging Jun, 2007 | Pubmed ID: 16725229
Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach.
Accounts of chemical research Sep, 2006 | Pubmed ID: 16981680
Early diagnostics and therapeutics for Alzheimer's disease--how early can we get there?
Expert review of neurotherapeutics Sep, 2006 | Pubmed ID: 17009917
Structural study of metastable amyloidogenic protein oligomers by photo-induced cross-linking of unmodified proteins.
Methods in enzymology , 2006 | Pubmed ID: 17046399
C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2008 | Pubmed ID: 18779585
The structure of Abeta42 C-terminal fragments probed by a combined experimental and theoretical study.
Journal of molecular biology Mar, 2009 | Pubmed ID: 19356595
Amino acid position-specific contributions to amyloid beta-protein oligomerization.
The Journal of biological chemistry Aug, 2009 | Pubmed ID: 19567875
RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity.
PloS one , 2009 | Pubmed ID: 19901993
Biophysical characterization of Abeta42 C-terminal fragments: inhibitors of Abeta42 neurotoxicity.
Biochemistry Feb, 2010 | Pubmed ID: 20050679
Despite its role in assembly, methionine 35 is not necessary for amyloid beta-protein toxicity.
Journal of neurochemistry Jun, 2010 | Pubmed ID: 20345758
Mechanistic investigation of the inhibition of Abeta42 assembly and neurotoxicity by Abeta42 C-terminal fragments.
Biochemistry Aug, 2010 | Pubmed ID: 20568734
Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease.
Nature chemistry Jul, 2009 | Pubmed ID: 20703363
Surprising toxicity and assembly behaviour of amyloid β-protein oxidized to sulfone.
The Biochemical journal Jan, 2011 | Pubmed ID: 21044048
Rational design of β-sheet ligands against Aβ42-induced toxicity.
Journal of the American Chemical Society Mar, 2011 | Pubmed ID: 21381732
Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins.
Journal of the American Chemical Society Oct, 2011 | Pubmed ID: 21916458
Induction of methionine-sulfoxide reductases protects neurons from amyloid β-protein insults in vitro and in vivo.
Biochemistry Dec, 2011 | Pubmed ID: 22059533
C-terminal tetrapeptides inhibit Aβ42-induced neurotoxicity primarily through specific interaction at the N-terminus of Aβ42.
Journal of medicinal chemistry Dec, 2011 | Pubmed ID: 22087474
Aβ(39-42) modulates aβ oligomerization but not fibril formation.
Biochemistry Jan, 2012 | Pubmed ID: 22129303
A Two-Step Strategy for Structure-Activity Relationship Studies of N-Methylated Aβ42 C-Terminal Fragments as Aβ42 Toxicity Inhibitors.
ChemMedChem Feb, 2012 | Pubmed ID: 22307963
Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms.
ChemMedChem Feb, 2012 | Pubmed ID: 22323134
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