Translational Research Program of Pediatric Orthopedics,
Department of Surgery,
Translational Research Program of Pediatric Orthopedics, Department of Surgery
Dr. Long earned his doctorate in developmental biology from Tufts University, and completed postdoctoral training at Harvard University. He received a master’s degree in biochemistry and molecular biology from the University of California, Santa Barbara, and a bachelor’s degree in cell biology from Peking University. Dr. Long began his independent research at Washington University School of Medicine in St. Louis, and served there as Professor of Medicine, Developmental Biology and Orthopedic Surgery until 2018 when he was appointed William Wikoff Smith Endowed Chair in Pediatric Genomic Research at the Children’s Hospital of Philadelphia. He currently also serves as Professor of Orthopedic Surgery at University of Pennsylvania. Dr. Long served as program co-chair for American Society of Bone and Mineral Diseases, and chair for Gordon Conference on Bones and Teeth. He currently serves as consulting editor for Journal of Clinical Investigation and associate editor for PLoS Genetics.
In his research, Dr. Long seeks to understand the fundamental mechanisms underlying normal skeletal biology and the pathophysiology of bone diseases. His group has made major contributions to the understanding of Hh, Wnt and Notch signaling in skeletal development and homeostasis. They also pioneered the studies of osteogenic signals in regulating cellular metabolism.
Glucose metabolism induced by Bmp signaling is essential for murine skeletal development.
Nature communications 11, 2018 | Pubmed ID: 30446646
Less Is More: Ditching Mitochondria Saves Hypoxic Cartilage.
Developmental cell 06, 2019 | Pubmed ID: 31163170
Inducible expression of Wnt7b promotes bone formation in aged mice and enhances fracture healing.
Bone research , 2020 | Pubmed ID: 32047703
Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment.
eLife 04, 2020 | Pubmed ID: 32286228
Diet-Induced Metabolic Dysregulation in Female Mice Causes Osteopenia in Adult Offspring.
Journal of the Endocrine Society Apr, 2020 | Pubmed ID: 32309754
The Amino Acid Sensor Eif2ak4/GCN2 Is Required for Proliferation of Osteoblast Progenitors in Mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 10, 2020 | Pubmed ID: 32453500
Both aerobic glycolysis and mitochondrial respiration are required for osteoclast differentiation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 08, 2020 | Pubmed ID: 32627870
Malic Enzyme Couples Mitochondria with Aerobic Glycolysis in Osteoblasts.
Cell reports 09, 2020 | Pubmed ID: 32905773
Biphasic regulation of glutamine consumption by WNT during osteoblast differentiation.
Journal of cell science 01, 2021 | Pubmed ID: 33262314
Functional interaction between Wnt and Bmp signaling in periosteal bone growth.
Scientific reports 05, 2021 | Pubmed ID: 34031510
The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair.
eLife 06, 2021 | Pubmed ID: 34085927
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