Jens Christian Schwamborn

Induced neural stem cells achieve long-term survival and functional integration in the adult mouse brain.

The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs.

TRIM32 modulates pluripotency entry and exit by directly regulating Oct4 stability.

Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia.

Expression of the Parkinson's Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32.

Nurr1:RXRα heterodimer activation as monotherapy for Parkinson's disease.

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells.

Parkinson's Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32.

CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons.

FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling.

Human induced pluripotent stem cell-derived neuronal progenitors are a suitable and effective drug discovery model for neurological mtDNA disorders.

A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification.

Millifluidic culture improves human midbrain organoid vitality and differentiation.

Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality.

Automated high-throughput high-content autophagy and mitophagy analysis platform.

Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients.

Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis.

Midbrain Organoids: A New Tool to Investigate Parkinson's Disease.

Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson's disease.

Machine learning-assisted neurotoxicity prediction in human midbrain organoids.

Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids.

Is serine racemase (SRR) a second hit target for LRRK2-G2019S induced Parkinson's disease?

Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations.

Transition metal dichalcogenides to optimize the performance of peptide-imprinted conductive polymers as electrochemical sensors.

The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1.

Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression.

Generation of isogenic control DJ-1-delP GC13 for the genetic Parkinson's disease-patient derived iPSC line DJ-1-delP (LCSBi008-A-1).

PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains T homeostasis during ageing.

Generalising from conventional pipelines using deep learning in high-throughput screening workflows.

Bone Tissue and the Nervous System: What Do They Have in Common?

Advanced brain organoids for neuroinflammation disease modeling.