David Rowe

Collagen and collagen-derived fragments are chemotactic for tumor cells.

Tracking COL1A1 RNA in osteogenesis imperfecta. splice-defective transcripts initiate transport from the gene but are retained within the SC35 domain.

A strategy for identifying osteoporosis risk genes.

Analysis of inhibitory action of modified U1 snRNAs on target gene expression: discrimination of two RNA targets differing by a 1 bp mismatch.

Stage specific inhibition of osteoblast lineage differentiation by FGF2 and noggin.

Inhibiting expression of specific genes in mammalian cells with 5' end-mutated U1 small nuclear RNAs targeted to terminal exons of pre-mRNA.

Dual reporter transgene driven by 2.3Col1a1 promoter is active in differentiated osteoblasts.

Hematopoiesis is severely altered in mice with an induced osteoblast deficiency.

Modified U1 snRNA suppresses expression of a targeted endogenous RNA by inhibiting polyadenylation of the transcript.

Comparison of the action of transient and continuous PTH on primary osteoblast cultures expressing differentiation stage-specific GFP.

Expression profile of osteoblast lineage at defined stages of differentiation.

Histological analysis of GFP expression in murine bone.

Modification of human U1 snRNA for inhibition of gene expression at the level of pre-mRNA.

Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation.

Heterogeneity of engrafted bone-lining cells after systemic and local transplantation.

Skeletal development, bone remodeling, and hematopoiesis.

Effects of transient PTH on early proliferation, apoptosis, and subsequent differentiation of osteoblast in primary osteoblast cultures.

Examination of mineralized nodule formation in living osteoblastic cultures using fluorescent dyes.

Use of an alpha-smooth muscle actin GFP reporter to identify an osteoprogenitor population.

Time lapse imaging techniques for comparison of mineralization dynamics in primary murine osteoblasts and the late osteoblast/early osteocyte-like cell line MLO-A5.

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche.

A BAC-bacterial recombination method to generate physically linked multiple gene reporter DNA constructs.

Identification of differentially expressed genes between osteoblasts and osteocytes.

Determination of the fate and contribution of ex vivo expanded human bone marrow stem and progenitor cells for bone formation by 2.3ColGFP.

Immature osteoblast lineage cells increase osteoclastogenesis in osteogenesis imperfecta murine.

Isolation of murine bone marrow derived mesenchymal stem cells using Twist2 Cre transgenic mice.

Long bone fracture repair in mice harboring GFP reporters for cells within the osteoblastic lineage.

Generation and characterization of Col10a1-mcherry reporter mice.

In vivo fate mapping identifies mesenchymal progenitor cells.

The effect of fresh bone marrow cells on reconstruction of mouse calvarial defect combined with calvarial osteoprogenitor cells and collagen-apatite scaffold.

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo.

Mechanical input restrains PPARγ2 expression and action to preserve mesenchymal stem cell multipotentiality.

A Bayesian Approach to Pathway Analysis by Integrating Gene-Gene Functional Directions and Microarray Data.

The paratenon contributes to scleraxis-expressing cells during patellar tendon healing.

Fabrication and characterization of biomimetic collagen-apatite scaffolds with tunable structures for bone tissue engineering.

Visualizing osteogenesis in vivo within a cell-scaffold construct for bone tissue engineering using two-photon microscopy.

Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells.

Osterix-cre labeled progenitor cells contribute to the formation and maintenance of the bone marrow stroma.

Developmental-like bone regeneration by human embryonic stem cell-derived mesenchymal cells.

Structural and biomechanical responses of osseous healing: a novel murine nonunion model.

Roles of parathyroid hormone (PTH) receptor and reactive oxygen species in hyperlipidemia-induced PTH resistance in preosteoblasts.

Local transplantation is an effective method for cell delivery in the osteogenesis imperfecta murine model.

Evaluation of rhBMP-2 and bone marrow derived stromal cell mediated bone regeneration using transgenic fluorescent protein reporter mice.

Lineage tracing of resident tendon progenitor cells during growth and natural healing.

Evaluation of osteogenic cell differentiation in response to bone morphogenetic protein or demineralized bone matrix in a critical sized defect model using GFP reporter mice.

Bone tissue engineering with a collagen-hydroxyapatite scaffold and culture expanded bone marrow stromal cells.

Modulation of Host Osseointegration during Bone Regeneration by Controlling Exogenous Stem Cells Differentiation Using a Material Approach.

Computer-Automated Static, Dynamic and Cellular Bone Histomorphometry.

A Site-Specific Integrated Col2.3GFP Reporter Identifies Osteoblasts Within Mineralized Tissue Formed In Vivo by Human Embryonic Stem Cells.

Mouse limb skeletal growth and synovial joint development are coordinately enhanced by Kartogenin.

Fibrin gels exhibit improved biological, structural, and mechanical properties compared with collagen gels in cell-based tendon tissue-engineered constructs.

Effects of cell-attachment and extracellular matrix on bone formation in vivo in collagen-hydroxyapatite scaffolds.

Fixation stability dictates the differentiation pathway of periosteal progenitor cells in fracture repair.

Ablating hedgehog signaling in tenocytes during development impairs biomechanics and matrix organization of the adult murine patellar tendon enthesis.

Combination therapy with PTH and DBM cannot heal a critical sized murine femoral defect.

Hydrogel-based Delivery of rhBMP-2 Improves Healing of Large Bone Defects Compared With Autograft.

Improved biomechanical and biological outcomes in the MRL/MpJ murine strain following a full-length patellar tendon injury.

Gdf5 progenitors give rise to fibrocartilage cells that mineralize via hedgehog signaling to form the zonal enthesis.

Improving the permeability of lyophilized collagen-hydroxyapatite scaffolds for cell-based bone regeneration with a gelatin porogen.

Cell and matrix response of temporomandibular cartilage to mechanical loading.

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

Identification of a progenitor cell population destined to form fracture fibrocartilage callus in Dickkopf-related protein 3-green fluorescent protein reporter mice.

Ectopic mineralization of cartilage and collagen-rich tendons and ligaments in Enpp1asj-2J mice.

Murine supraspinatus tendon injury model to identify the cellular origins of rotator cuff healing.

Quiescent Bone Lining Cells Are a Major Source of Osteoblasts During Adulthood.

The LG/J Murine Strain Exhibits Near-Normal Tendon Biomechanical Properties Following a Full-Length Central Patellar Tendon Defect.

Variable patterns of ectopic mineralization in Enpp1asj-2J mice, a model for generalized arterial calcification of infancy.

Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs.

Screening Gene Knockout Mice for Variation in Bone Mass: Analysis by μCT and Histomorphometry.

Dickkopf-3 in aberrant endothelial secretome triggers renal fibroblast activation and endothelial-mesenchymal transition.

Osteochondral Differentiation of Fluorescent Multireporter Cells on Zonally-Organized Biomaterials.

Histological Criteria that Distinguish Human and Mouse Bone Formed Within a Mouse Skeletal Repair Defect.

Biodegradable nanofiber-based piezoelectric transducer.

Stepwise strategy for generating osteoblasts from human pluripotent stem cells under fully defined xeno-free conditions with small-molecule inducers.

Intrafibrillar Mineralized Collagen-Hydroxyapatite-Based Scaffolds for Bone Regeneration.

Skeletal screening IMPC/KOMP using μCT and computer automated cryohistology: Application to the Efna4 KO mouse line.

Effects of acidosis on the structure, composition, and function of adult murine femurs.

Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice.

Predicting the targets of IRF8 and NFATc1 during osteoclast differentiation using the machine learning method framework cTAP.

Stem cell-based modeling and single-cell multiomics reveal gene-regulatory mechanisms underlying human skeletal development.

Modeling of intramembranous ossification using human pluripotent stem cell-derived paraxial mesoderm derivatives.

Biodegradable Nanofiber Bone-Tissue Scaffold as Remotely-Controlled and Self-Powering Electrical Stimulator.